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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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9.996953 | ABIN214503 | IHC IHC (p) WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | ||
9.996953 | ABIN1030452 | IHC ELISA WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
9.996953 | ABIN5545934 | IHC ELISA | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
9.996953 | ABIN2431541 | IHC ELISA | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
5.5 | ABIN1002560 | IHC ELISA WB | Rabbit | IgG | C-Term | Anmelden zum Anzeigen | Polyclonal | 4 | ||
5.157918 | ABIN5946619 | FACS ICC IF IHC IHC (p) IP WB | Rabbit | IgG | Anmelden zum Anzeigen | SC0617 | 0 | |||
1 | ABIN6039589 | ELISA IHC | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
1 | ABIN1887368 | IHC ELISA WB | Rabbit | C-Term | Anmelden zum Anzeigen | Polyclonal | 0 | |||
0.657918 | ABIN4327614 | ELISA ICC IF IHC IHC (p) WB | Rabbit | Anmelden zum Anzeigen | Polyclonal | 2 |
General |
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Antigen | Interferon Regulatory Factor 7 (IRF7) Antikörper |
Reaktivität | Human, Maus, Ratte (Rattus) Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser IRF7 Antikörper ist unkonjugiert Alternativen |
Applikation |
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-IRF7 AntikörperTarget Details IRF7 Anwendungsinformationen Handhabung Bilder |
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Spezifität | IRF7 Antibody detects endogenous levels of total IRF7 |
Kreuzreaktivität | Human, Maus, Ratte (Rattus) |
Reinigung | The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific). |
Immunogen | A synthesized peptide derived from human IRF7 |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details IRF7Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | IRF7 (IRF7 Antibody Abstract) |
Hintergrund |
Description: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. Gene: IRF7 |
Molekulargewicht | 54 kDa |
Gen-ID | 3665 |
UniProt | Q92985 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie |
AnwendungsinformationenProduktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Bilder zurück nach oben |
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Applikations-hinweise | WB 1:1000-3000 IHC 1:200 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | 1 mg/mL |
Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Lagerung | -20 °C |
Informationen zur Lagerung | Store at -20 °C.Stable for 12 months from date of receipt |
Haltbarkeit | 12 months |
BilderProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung zurück nach oben |
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Bilder des Herstellers |