anti-Maus IRF7 Antikörper für Immunohistochemistry

Recommended IRF7 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 7 (IRF7) Antikörper
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
  • IRF7
  • irf7
  • IRF-7H
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • interferon regulatory factor 7
  • irf7
  • IRF7
  • Irf7
Reaktivität
Human, Maus, Ratte (Rattus)
149
59
55
3
2
2
2
2
1
1
Wirt
Kaninchen
107
42
Klonalität
Polyklonal
Konjugat
Dieser IRF7 Antikörper ist unkonjugiert
7
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
103
50
27
26
24
10
6
5
4
2
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Western Blotting (WB) image for anti-Interferon Regulatory Factor 7 (IRF7) antibody (ABIN6262657)
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) antibody (ABIN6262657)
Produktnummer ABIN6262657
$ 390.77
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
8.404629 ABIN214503 IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
8.404629 ABIN1030452 IHC ELISA WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
8.404629 ABIN5545934 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
8.404629 ABIN2431541 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN5946619 FACS ICC IF IHC IHC (p) IP WB Rabbit IgG Anmelden zum Anzeigen SC0617 0
1 ABIN4327614 ELISA ICC IF IHC IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 2
1 ABIN1002560 IHC ELISA WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 4
1 ABIN6039589 ELISA IHC Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1887368 IHC ELISA WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 7 (IRF7) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(149), (59), (55), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(107), (42)
Klonalität
Polyklonal
Konjugat Dieser IRF7 Antikörper ist unkonjugiert
(7), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(103), (50), (27), (26), (24), (10), (6), (5), (4), (2), (2), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IRF7 Antikörper

Target Details IRF7 Anwendungsinformationen Handhabung Bilder
Spezifität IRF7 Antibody detects endogenous levels of total IRF7
Kreuzreaktivität Human, Maus, Ratte (Rattus)
Reinigung The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Immunogen A synthesized peptide derived from human IRF7
Isotyp IgG
Plasmids, Primers & others

Target Details IRF7

Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IRF7 (IRF7 Antibody Abstract)
Hintergrund

Description: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Gene: IRF7
Molekulargewicht 54 kDa
Gen-ID 3665
UniProt Q92985
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie

Anwendungsinformationen

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:1000-3000 IHC 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C.Stable for 12 months from date of receipt
Haltbarkeit 12 months

Bilder

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Interferon Regulatory Factor 7 (IRF7) antibody (ABIN6262657) Western blot analysis IRF7 using 293 whole cell lysates
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) antibody (ABIN6262657) ABIN6277717 at 1/100 staining Human liver tissue by IHC-P. The sample was formaldehyd...