anti-Maus IRF7 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended IRF7 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 7 (IRF7) Antikörper
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
  • IRF7
  • irf7
  • IRF-7H
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • interferon regulatory factor 7
  • irf7
  • IRF7
  • Irf7
Epitop
pSer471, pSer472, AA 450-490
30
23
15
14
14
14
6
5
5
4
4
3
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
154
59
55
3
3
3
2
2
2
1
1
Wirt
Kaninchen
108
46
Klonalität
Polyklonal
Konjugat
Dieser IRF7 Antikörper ist unkonjugiert
7
7
6
6
6
6
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
108
55
26
26
25
10
6
5
4
2
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN742703
$ 340.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN682603 IF (p) IHC (p) WB Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 3
1 ABIN903073 IF (p) Alexa Fluor 488 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903077 IF (p) Alexa Fluor 647 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903074 IF (p) Alexa Fluor 350 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN903075 IF (p) Alexa Fluor 555 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742706 IF (p) Cy3 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742707 IF (p) Cy5 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742708 IF (p) Cy5.5 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742709 IF (p) Cy7 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742710 IF (p) FITC Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682608 IF (p) Cy5.5 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682606 IF (p) Cy3 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682607 IF (p) Cy5 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682609 IF (p) Cy7 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682610 IF (p) FITC Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN876334 IF (p) Alexa Fluor 488 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN876336 IF (p) Alexa Fluor 647 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN876338 IF (p) Alexa Fluor 350 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN876335 IF (p) Alexa Fluor 555 Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2814920 IF (p) Alexa Fluor 594 Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 7 (IRF7) Antikörper
Epitop pSer471, pSer472, AA 450-490
(30), (23), (15), (14), (14), (14), (6), (5), (5), (4), (4), (3), (2), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(154), (59), (55), (3), (3), (3), (2), (2), (2), (1), (1)
Wirt Kaninchen
(108), (46)
Klonalität
Polyklonal
Konjugat Dieser IRF7 Antikörper ist unkonjugiert
(7), (7), (6), (6), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(108), (55), (26), (26), (25), (10), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IRF7 Antikörper

Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IRF7 around the phosphorylation site of Ser471/472
Isotyp IgG
Plasmids, Primers & others

Target Details IRF7

Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben
Antigen
Andere Bezeichnung Irf7 (IRF7 Antibody Abstract)
Hintergrund

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Subcellular location: Nucleus

Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7

Gen-ID 3665
UniProt Q92985
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie

Anwendungsinformationen

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Referenzen für anti-IRF7 Antikörper (ABIN742703) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-IRF7 Antikörper (ABIN742703)

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Le Bel, Gosselin: "Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection." in: PLoS ONE, Vol. 10, Issue 10, pp. e0139856, 2015 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: Lung

Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, 2014 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: "Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection." in: Journal of virology, Vol. 87, Issue 13, pp. 7301-8, 2013 Von den Autoren verwendete Methode: Western Blotting (WB)

Bilder

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN742703) zurück nach oben
Bilder des Herstellers
SDS-PAGE (SDS) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Lane 1: mouse embryo lysates Lane 2: mouse brain lysates probed with Anti Phospho-IRF...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Formalin-fixed and paraffin embedded mouse pancreas tissue labeled with Anti-Phospho-...
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Formalin-fixed and paraffin embedded rat spleen tissue labeled with Anti-Phospho-IRF7...
Western Blotting (WB) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 450-490), (pSer471), (pSer472) antibody (ABIN742703) Lane 1: Mouse uterus lysates, Lane 2: Mouse large intestine lysates probed with IRF7 ...