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Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validierenRelevance Score | ABIN | Application | Konjugat | Host | Isotype | Epitope | Hersteller | Clonality | References | Details |
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10 | ABIN2736992 | FACS IP WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 | |||
5.0709047 | ABIN5946619 | FACS ICC IF IHC IHC (p) IP WB | Rabbit | IgG | Anmelden zum Anzeigen | SC0617 | 0 | |||
1 | ABIN6672000 | FACS IP WB | Rabbit | IgG | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Interferon Regulatory Factor 7 (IRF7) Antikörper |
Reaktivität | Maus, Ratte (Rattus), Human Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Dieser IRF7 Antikörper ist unkonjugiert Alternativen |
Applikation |
Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
Alternativen
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Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-IRF7 AntikörperTarget Details IRF7 Anwendungsinformationen Handhabung Bilder |
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Reinigung | Affinity purification |
Immunogen | A synthetic peptide of human IRF7 |
Isotyp | IgG |
Plasmids, Primers & others | |
Target Details IRF7Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | IRF7 (IRF7 Antibody Abstract) |
Hintergrund |
Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3gamma/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E). IRF-7, which is functionally similar to IRF-3, is preferentially expressed in lymphoid cells and induced by virus, LPS, and IFN-alpha. IRF-7 plays an essential role in the induction of type I interferon in response viral infecton. Like IRF-3, IRF-7 is regulated at multiple serine phosphorylation sites near its carboxyl terminus, which are required for nuclear translocation, DNA binding, and transcriptional activity. Synonyms: IRF7, IRF-7H, IRF7A, Interferon regulatory factor 7 |
Gen-ID | 3665 |
UniProt | Q92985 |
Pathways | TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie |
AnwendungsinformationenProduktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Bilder zurück nach oben |
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Applikations-hinweise | Recommended dilutions: WB: 1:1000-1:2000, IP: 1:20-1:50, FC: 1:50-1:100 |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Bilder zurück nach oben |
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Format | Liquid |
Buffer | PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3 |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid freeze / thaw cycles |
Lagerung | -20 °C/-80 °C |
BilderProduktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung zurück nach oben |
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Bilder des Herstellers |