anti-Human IRF7 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended IRF7 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 7 (IRF7) Antikörper
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
  • IRF7
  • irf7
  • IRF-7H
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • interferon regulatory factor 7
  • irf7
  • IRF7
  • Irf7
Epitop
AA 420-470
26
22
15
15
15
14
6
5
5
4
4
3
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
149
59
55
3
2
2
2
2
1
1
Wirt
Kaninchen
107
42
Klonalität
Polyklonal
Konjugat
Dieser IRF7 Antikörper ist unkonjugiert
7
6
6
6
6
6
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
103
51
26
25
25
10
6
5
4
2
2
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN682603
$ 318.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
17.5 ABIN742703 IF (p) IHC (p) WB Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 3
14.116879 ABIN6391259 ELISA IHC IHC (p) WB Mouse IgG1, kappa AA 1-150 Anmelden zum Anzeigen 3D9 0
13 ABIN5518764 IHC (p) WB Rabbit IgG AA 31-67, N-Term Anmelden zum Anzeigen Polyclonal 0
13 ABIN263914 EIA IHC (p) WB Mouse IgG1 AA 1-150, N-Term Anmelden zum Anzeigen 3D9 3
11.116879 ABIN214503 IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
11.116879 ABIN213948 IHC IHC (p) WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
7 ABIN1723206 IHC (p) ELISA WB Mouse IgG1 kappa AA 1-150 Anmelden zum Anzeigen 3D9 0
4 ABIN303273 IHC (p) WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 4
4 ABIN302831 IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
4 ABIN1736031 IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
4 ABIN1736032 IHC (p) WB Rabbit IgG Internal Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN5554906 EIA IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN742712 IHC (p) WB HRP Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682612 IHC (p) WB HRP Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN742705 IHC (p) WB Biotin Rabbit IgG pSer471, pSer472, AA 450-490 Anmelden zum Anzeigen Polyclonal 0
1 ABIN682605 IHC (p) WB Biotin Rabbit IgG AA 420-470 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2768953 ELISA IHC (p) WB Mouse IgG1, kappa AA 1-150 Anmelden zum Anzeigen 3D9 0
1 ABIN2768648 IHC (p) WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN2768649 IHC (p) WB Rabbit Internal Region Anmelden zum Anzeigen Polyclonal 0
1 ABIN5554907 ELISA IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 7 (IRF7) Antikörper
Epitop AA 420-470
(26), (22), (15), (15), (15), (14), (6), (5), (5), (4), (4), (3), (2), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(149), (59), (55), (3), (2), (2), (2), (2), (1), (1)
Wirt Kaninchen
(107), (42)
Klonalität
Polyklonal
Konjugat Dieser IRF7 Antikörper ist unkonjugiert
(7), (6), (6), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(103), (51), (26), (25), (25), (10), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IRF7 Antikörper

Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN682603) Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IRF7
Isotyp IgG
Plasmids, Primers & others

Target Details IRF7

Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN682603) Bilder zurück nach oben
Antigen
Andere Bezeichnung Irf7 (IRF7 Antibody Abstract)
Hintergrund

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.

Subcellular location: Cytoplasm, Nucleus

Synonyms: IRF7A, IRF7B, IRF7C, IRF7H, IRF-7H, Interferon regulatory factor 7, IRF-7, IRF7

Gen-ID 3665
UniProt Q92985
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie

Anwendungsinformationen

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Referenzen für anti-IRF7 Antikörper (ABIN682603) Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Referenzen für anti-IRF7 Antikörper (ABIN682603) Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen für anti-IRF7 Antikörper (ABIN682603)

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Lopušná, Benkóczka, Lupták, Matúšková, Lukáčiková, Ovečková, Režuchová: "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." in: Cytokine, Vol. 83, pp. 158-70, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Cai, Jiang, Pan, Chen, Zhang, Zhu, Cai, Ling, Chen, Xu, Chen: "Transcriptomic analysis of hepatic responses to testosterone deficiency in miniature pigs fed a high-cholesterol diet." in: BMC genomics, Vol. 16, pp. 59, 2015 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Pig (Porcine)). Weitere Details: Sample: liver

Han, Choi, Uyangaa, Kim, Kim, Kim, Kim, Eo: "Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways." in: PLoS pathogens, Vol. 10, Issue 9, pp. e1004319, 2014 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Bilder

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN682603) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 420-470) antibody (ABIN682603) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-IRF7 Poly...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 420-470) antibody (ABIN682603) Paraformaldehyde-fixed, paraffin embedded rat brain tissue, Antigen retrieval by boil...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interferon Regulatory Factor 7 (IRF7) (AA 420-470) antibody (ABIN682603) Paraformaldehyde-fixed, paraffin embedded rat lung tissue, Antigen retrieval by boili...