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Human IRF5 Protein expressed in HEK-293 Cells - ABIN2723539
Griesbeck, Ziegler, Laffont, Smith, Chauveau, Tomezsko, Sharei, Kourjian, Porichis, Hart, Palmer, Sirignano, Beisel, Hildebrandt, Cénac, Villani, Diefenbach, Le Gall, Schwartz, Herbeuval, Autran et al.: Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women. ... in Journal of immunology (Baltimore, Md. : 1950) 2015
this study shows that interferon regulatory factor 5 regulates the expression of matrix metalloproteinase-3 (zeige MMP3 Proteine) in human chondrocytes
The presence of the interferon regulatory factor 5 rs2004640 T allele increases the risk of nephritis development in Egyptian children with systemic lupus erythematosus.
IRF5 was an adverse independent prognostic factor for both overall survival and recurrence free survival in patients with non-metastatic ccRCC.
Data suggest that IRAK4 (zeige IRAK4 Proteine) activity regulates activation of IRF5, TAK1 (zeige MAP3K7 Proteine), and IKKB (zeige IKBKB Proteine) in monocytes; IRAK4 (zeige IRAK4 Proteine) activation of TAK1 (zeige MAP3K7 Proteine)-IKKB (zeige IKBKB Proteine)-IRF5 axis leads to induction of cytokines and interferons following TLR7 (zeige TLR7 Proteine)/TLR8 (zeige TLR8 Proteine) stimulation. (IRAK4 (zeige IRAK4 Proteine) = interleukin-1 receptor-associated kinase 4 (zeige IRAK4 Proteine); IRF5 = interferon regulatory factor-5; TAK1 (zeige MAP3K7 Proteine) = MAPK (zeige MAPK1 Proteine) kinase kinase 7; IKKB (zeige IKBKB Proteine) = I-kappa B kinase; TLR = toll (zeige TLR4 Proteine)-like receptor)
IRF5 and IRF5 disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 (zeige AKT2 Proteine) activation.
the genomic pattern according to MATH demonstrated that mutation rates of TP53, IRF5 and KRAS were independently associated with MATH, and the latter two were only significant in male patients. As MATH increased, the fraction of somatic copy number alteration (SCNA) elevated. Moreover, more SCNA events was independently associated with MATH in male than in female
IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1 (zeige VCAM1 Proteine)) at the transcriptional level by binding to its promoter.
oncogenic IRF5 overexpression in HL is the result of a specific LTR transcriptional activation
the primary activating regulatory region of human IRF5 was located in its minimal promoter region between nucleotides -179 and +62. In addition, it was shown that Sp1 (zeige PSG1 Proteine) was able to bind to the multiple sites in IRF5 promoter region, and was involved in the transcriptional regulation of IRF5 at the basal level.
This study demonstrates the association of IRF5 with an increased susceptibility for systemic lupus erythematosus (SLE) in the population of Crete and emphasizes the association of the Neanderthal-derived IRF5 haplotype with SLE susceptibility. Patients carrying allele the Neanderthal allele C had greater type I IFN, supporting a functional consequence of this polymorphism.
Aged mice expressed higher IRF5 levels in the ischemic brains, suggesting that aging has a significant influence on stroke outcomes in mice, which is probably mediated by age-specific inflammatory responses.
this study shows a critical role for IRF5 in regulating allergic airway inflammation
BCG (zeige SLC11A1 Proteine) increased membrane expression of TRIM59 through the TLR2/ TLR4 (zeige TLR4 Proteine)/IRF5 pathway in RAW264.7 macrophage cell line.
these results reveal a role for Lyn (zeige LYN Proteine) as a specific suppressor of the TLR-MyD88 (zeige MYD88 Proteine)-IRF5 pathway and illustrate the importance of fine-tuning IRF5 activity for the maintenance of immune homeostasis
IRF5 siRNA reverses pancreatitis-induced activation of lung macrophages from M1 phenotype to M2 phenotype in severe acute pancreatitis associated with acute lung injury.
Our data show that miR (zeige MLXIP Proteine)-146b targets IRF5, resulting in the regulation of macrophage activation. Furthermore, miR (zeige MLXIP Proteine)-146b deficient mice developed intestinal inflammation with enhanced M1 macrophage polarization.
data suggest that IRF5 plays a causal role in inflammation, fibrosis and impaired vascular EC function in Tsk (zeige FBN1 Proteine)/+ mice
study sheds light on the TLR4 (zeige TLR4 Proteine)-IRF5 pathway in the pathology of SSc (zeige CYP11A1 Proteine) with clinical implications of targeting the IRF5 pathways in the suppression of disease development
Collectively, these results indicate a key role for IRF-5 in modulating the host antiviral response in peripheral organs that controls bunyavirus neuroinvasion in mice.
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
interferon regulatory factor 5
, Interferon regulatory factor 5
, interferon regulatory factor 5-like
, interferon regulatory factor 5 bone marrow