anti-Maus Interferon Regulatory Factor 3 Antikörper für Immunohistochemistry

Recommended Interferon Regulatory Factor 3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 3 (IRF3) Antikörper
  • irf3
  • IRF3
  • C920001K05Rik
  • IRF-3
  • interferon regulatory factor 3
  • interferon regulatory factor 7
  • irf3
  • IRF3
  • irf-3
  • Irf3
  • IRF7
Reaktivität
Maus, Ratte (Rattus), Human
295
123
72
6
6
6
3
2
2
1
1
1
1
Wirt
Kaninchen
264
61
3
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
6
6
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
272
132
105
80
49
40
28
26
25
14
14
8
4
3
3
3
2
2
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN3023115
$ 393.25
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
19 ABIN5998004 IF/ICC IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
15.974996 ABIN6567127 IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
15.802004 ABIN3185228 ELISA IHC WB Rabbit IgG Ser608 Anmelden zum Anzeigen Polyclonal 0
12.974996 ABIN6270186 ELISA IHC WB Rabbit IgG pSer15 Anmelden zum Anzeigen Polyclonal 0
12.974996 ABIN6262652 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
12.974996 ABIN2957643 IC IF IHC WB Rabbit C-Term, pSer385 Anmelden zum Anzeigen Polyclonal 0
12.974996 ABIN2428297 IHC ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
10 ABIN1868750 ICC IHC WB Rabbit IgG AA 1-406 Anmelden zum Anzeigen Polyclonal 0
10 ABIN2935238 IF/ICC IHC IP WB Rabbit AA 1-406 Anmelden zum Anzeigen Polyclonal 0
9.974996 ABIN1532452 IHC ELISA WB Rabbit IgG AA 362-411 Anmelden zum Anzeigen Polyclonal 0
9.974996 ABIN6255296 IHC WB Rabbit IgG pSer396 Anmelden zum Anzeigen Polyclonal 0
9.974996 ABIN213923 IF IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
9.974996 ABIN1030450 IHC ELISA WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
9.974996 ABIN2421745 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
7 ABIN1577321 IHC ELISA WB Rabbit IgG Ser396 Anmelden zum Anzeigen Polyclonal 0
6.9749956 ABIN2610443 IHC IHC (p) IP WB Rabbit IgG AA 275-325 Anmelden zum Anzeigen Polyclonal 0
5.5 ABIN1002558 IHC ELISA WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 4
5.5 ABIN6673522 IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 1
5.2301655 ABIN5946612 FACS ICC IF IHC IHC (p) WB Rabbit IgG Anmelden zum Anzeigen SD2062 0
4 ABIN2888732 ELISA IHC WB Rabbit IgG AA 362-411 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 3 (IRF3) Antikörper
Reaktivität Maus, Ratte (Rattus), Human
(295), (123), (72), (6), (6), (6), (3), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(264), (61), (3)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(7), (6), (6), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunohistochemistry (IHC), Western Blotting (WB)
(272), (132), (105), (80), (49), (40), (28), (26), (25), (14), (14), (8), (4), (3), (3), (3), (2), (2), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Reinigung Affinity purification
Immunogen Recombinant protein of human IRF3
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung IRF3 (IRF3 Antibody Abstract)
Hintergrund Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3gamma/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E). IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal Ser and Thr residues (between 385 and 405), leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity. During infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKepsilon and TBK1. IRF-3 is phosphorylated at Ser396 following viral infection, expression of viral nucleocapsid, and double-stranded RNA treatment. These events likely play a role in activation of IRF-3.
Synonyms: IRF-3, IRF3
Gen-ID 3661
UniProt Q14653
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikations-hinweise Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze / thaw cycles
Lagerung -20 °C/-80 °C

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Qian, Fan, Liu, Wu, Zhang, Cui, Zhou, Hu, Wei, Chen, Li, Qian: "Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage." in: Journal of virology, Vol. 91, Issue 16, 2017 Von den Autoren verwendete Methode: Western Blotting (WB), Immunofluorescence (IF)

Zhong, Wang, Fang, Zhang, Luo, Shang, Ouyang, Ouyang, Chen, Xiao: "Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling." in: PLoS ONE, Vol. 8, Issue 11, pp. e80976, 2013

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Interferon Regulatory Factor 3 (IRF3) antibody (ABIN3023115) Western blot analysis of extracts of various cell lines, using IRF3 antibody.
Immunofluorescence (IF) image for anti-Interferon Regulatory Factor 3 (IRF3) antibody (ABIN3023115) Immunofluorescence analysis of U2OS cell using IRF3 antibody. Blue: DAPI for nuclear ...