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Human Monoclonal IRF3 Primary Antibody für Inhibition, IF - ABIN967285
Au, Moore, Lowther, Juang, Pitha: Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Monoclonal IRF3 Primary Antibody für WB - ABIN967306
Darnell, Kerr, Stark: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. in Science (New York, N.Y.) 1994
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Mouse (Murine) Polyclonal IRF3 Primary Antibody für WB - ABIN1881465
Marichal, Bedoret, Mesnil, Pichavant, Goriely, Trottein, Cataldo, Goldman, Lekeux, Bureau, Desmet: Interferon response factor 3 is essential for house dust mite-induced airway allergy. in The Journal of allergy and clinical immunology 2010
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Human Polyclonal IRF3 Primary Antibody für IHC, ELISA - ABIN1002558
Malmgaard: Induction and regulation of IFNs during viral infections. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004
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Human Polyclonal IRF3 Primary Antibody für ICC, ELISA - ABIN1002559
Fitzgerald, McWhirter, Faia, Rowe, Latz, Golenbock, Coyle, Liao, Maniatis: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. in Nature immunology 2003
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Human Polyclonal IRF3 Primary Antibody für IF (cc), IF (p) - ABIN742688
Menasria, Boivin, Lebel, Piret, Gosselin, Boivin: Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response against Herpes Simplex Virus 1 Infection. in Journal of virology 2013
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Human Monoclonal IRF3 Primary Antibody für BR, IF - ABIN2689798
Hiscott, Pitha, Genin, Nguyen, Heylbroeck, Mamane, Algarte, Lin: Triggering the interferon response: the role of IRF-3 transcription factor. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999
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Human Polyclonal IRF3 Primary Antibody für IF (cc), IF (p) - ABIN742695
Ichikawa, Sugiura, Koarai, Minakata, Kikuchi, Morishita, Oka, Kanai, Kawabata, Hiramatsu, Akamatsu, Hirano, Nakanishi, Matsunaga, Yamamoto, Ichinose: TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. in Journal of immunology (Baltimore, Md. : 1950) 2014
Human Polyclonal IRF3 Primary Antibody für IF (p), IHC (p) - ABIN682588
Fan, Li, Zhu, Sui, Chen, Deng, Sui, Wang: NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows. in Biotechnology letters 2016
Human Monoclonal IRF3 Primary Antibody für IP, ELISA - ABIN2475141
Takahasi, Suzuki, Horiuchi, Mori, Suhara, Okabe, Fukuhara, Terasawa, Akira, Fujita, Inagaki: X-ray crystal structure of IRF-3 and its functional implications. in Nature structural biology 2003
Following spring viremia of carp (zeige ANKRD1 Antikörper) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (zeige ANKRD1 Antikörper) virus. data provide evidence that fish and mammals have evolved a similar IRF (zeige TRIM63 Antikörper)-dependent regulatory mechanism fine-tuning IFN gene activation.
Interferon (zeige IFNA Antikörper) regulatory factor (IRF (zeige TRIM63 Antikörper))10 inhibits the expression of IFN1 and IFN3 to avoid an excessive immune response, a unique regulation mechanism of the IFN responses in lower vertebrates.
Hepatitis A virus protein 2B suppresses beta interferon (zeige IFNA Antikörper) (IFN) gene transcription by interfering with IFN regulatory factor 3 activation.
MyD88 (zeige MYD88 Antikörper) interacts with interferon (zeige IFNA Antikörper) regulatory factor (IRF) 3 and IRF7 (zeige IRF7 Antikörper) in Atlantic salmon (Salmo salar)
In the current study, we studied the role of MITA (Mediator of IRF3 Activation (zeige TMEM173 Antikörper)), a regulator of innate immunity, in the regulation of autophagy and its implication in cell death of breast cancer cells. Here, we report that MITA (zeige TMEM173 Antikörper) inhibits the fusion of autophagosome with lysosome as evident from different autophagy flux assays
New research suggests that altering a subset of extracellular matrix factors, including interferon (zeige IFNA Antikörper) regulatory factor (IRF)3 and casein kinase (CK)2 (zeige CSNK2A1 Antikörper), may decrease the migratory potential of these aggressive tumors.
IRF-3 gene polymorphisms were associated with the susceptibility and prognosis of CLL, it can be used as an auxiliary index for clinical detection of CLL.
Clarithromycin acts a crucial modulator of the innate immune response, particularly IFN production, by modulating IRF-3 dimerization and subsequent translocation to the nucleus of airway epithelial cells.
c-Cbl (zeige CBL Antikörper) negatively regulates IFN-beta (zeige IFNB1 Antikörper) signaling and cellular antiviral response by promoting IRF3 ubiquitination and degradation.
data describe an unappreciated role for EAP30 in IRF3-dependent innate antiviral response in the nucleus.
IRF-3 is an important regulator of ORMDL3 (zeige ORMDL3 Antikörper) induction following RSV infection by binding directly to the promoter of ORMDL3 (zeige ORMDL3 Antikörper)
above findings suggest that ATG5-ATG12 positively regulate anti-viral NF-kappaB and IRF3 signaling during FMDV infection, thereby limiting FMDV proliferation. FMDV has evolved mechanisms to counteract the antiviral function of ATG5-ATG12, via degradation of them by viral protein 3C(pro).
NEMO (zeige IKBKG Antikörper)-IKKbeta (zeige IKBKB Antikörper) Are Essential for IRF3 and NF-kappaB (zeige NFKB1 Antikörper) Activation in the cGAS-STING Pathway
these data suggest that HNSs, an antagonist of host innate immunity, interacts with TBK1 (zeige TBK1 Antikörper) and thereby hinders the association of TBK1 (zeige TBK1 Antikörper) with its substrate IRF3, thus blocking IRF3 activation and transcriptional induction of the cellular antiviral responses.
The authors used recombinant classical swine fever virus N(pro) and swine IRF3 proteins and show that N(pro) interacts with IRF3 directly without additional proteins and forms a soluble 1:1 complex.
Amino acid residues in the N-terminal domain of Npro are involved in the stability of Npro, in interaction of Npro with IRF-3 and subsequent degradation of IRF-3, leading to downregulation of IFN-alpha (zeige IFNA Antikörper)/beta production.
The obtained results showed that PRRSV nsp1 could inhibit Poly(I:C)-induced IFN-beta (zeige IFNB1 Antikörper) promoter activity in MARC (zeige CCL7 Antikörper)-145 cells by down-regulating the protein level of IRF-3 and inhibiting the phosphorylation of IRF-3.
proteasomal degradation of IRF3 is induced by a direct or indirect interaction with N(pro).
IRF3 expression and activation depend on the signal transduction of the the urotensin II (zeige UTS2 Antikörper)/urotensin receptor (zeige UTS2R Antikörper) (UII (zeige UTS2 Antikörper)/UT) system, and play important roles in UII (zeige UTS2 Antikörper)/UT
Interruption of IRF3-dependent signaling resulted in decreased cardiac expression of inflammatory cytokines and chemokines and decreased inflammatory cell infiltration of the heart, as well as in attenuated ventricular dilation and improved cardiac function.
This study reveals a critical role of NSD3 (zeige WHSC1L1 Antikörper)-mediated IRF3 methylation in enhancing antiviral innate immunity.
these results suggested that the basal promoter activity of the mIRF-3 gene is regulated by transcription factors Egr2 (zeige EGR2 Antikörper) and YY1 (zeige YY1 Antikörper) in NIH3T3 cells
Data show that stimulator of interferon (zeige IFNA Antikörper) genes (STING)-associated vasculopathy with onset in infancy (SAVI)-associated STING N153S mutation triggers IRF3-independent immune cell dysregulation and lung disease in mice.
study provided evidence that the ability of ICP34.5 to control IRF3 activation is through its ability to reverse translational shutoff and sustain the expression of other IFN inhibitors encoded by the virus
This study did not find non-conservative mutations among SJL, B10.S, B6 and B10 mice in the IRF3 amino acid sequence, and show SJL bone marrow-derived macrophages infected with Theiler's murine encephalomyelitis virus exhibit increased virus RNA replication and infectious virus yields as well as greater IL-6 production than C57Bl strain (including B10.S) cultures.
The IRF-3 pathway is essential for tick-borne encephalitis virus-induced RANTES (zeige CCL5 Antikörper) production in the brain.
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta (zeige IFNB1 Antikörper) promoter activity and induces IRF3 degradation.
cpBVDV infection causes a marked loss of interferon regulatory factor 3 (IRF-3), a cellular transcription factor that controls interferon (zeige IFNA Antikörper) synthesis.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
interferon regulatory factor 3
, interferon regulatory factor 3-like