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Study found that non-canonical NF-kappaB p52 levels are inversely proportional to IotaKappaKappaepsilon, and growth of triple negative breast cancer cells in anchorage supportive, high-attachment conditions requires IKKepsilon and activated MEK. IKKepsilon and MEK cooperate to support overall viability whereas the p52 transcription factor is only required for viability in low attachment conditions, underscoring the con...
fascin1 constitutively interacts with IkappaB kinase (IKK) in the RIG-I signaling pathway. In summary, we have identified fascin1 as a suppressor of the RIG-I signaling pathway associating with IkappaB kinase in DLD-1 colon cancer cells to suppress immune responses to viral infection.
Single-Nucleotide Polymorphism in IKBKE gene had a strong association with resistance or susceptibility to dengue disease.
These findings indicated that microRNA-98 could promote apoptosis of glioma cells via inhibiting inhibitor of kappa B kinase epsilon/nuclear factor-kappa B signaling and presented a novel regulatory pathway of microRNA-98 by direct suppression of inhibitor of kappa B kinase epsilon/nuclear factor-kappa B expression in glioma cells.
In conclusion, the spindle cell morphology should be induced by RelA activation (p-RelA S468) by IKKepsilon upregulation in human herpesvirus 8 vFLIP-expressing EA hy926 cells.
Studied association between nuclear factor kappa beta1/IKK epsilon (NF-kappaB1/IKKepsilon) gene expression and clinical activity in rheumatoid arthritis (RA). Found there were significant differences in NF-kappaB1 and IKKepsilon gene expression (P = .001 and P = .029, respectively) between RA patients with clinical activity and clinical remission.
IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
Inverse association between IKKepsilon and lymph node metastasis in breast cancer.
YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
results demonstrate that Sphingosine 1-phosphate lyase (SPL) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL, which provides a mechanistic understanding of the pro-IFN activity of SPL
Virus-activated kinase IKKepsilon phosphorylated YAP at Ser403 and thereby triggered degradation of YAP in lysosomes and, consequently, relief of YAP-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 negatively regulates miR-let-7b/i by overexpressing and silencing YAP1 expression. In addition, miR-let-7b/i feedback decreases the expression of IKBKE and YAP1 and suppresses the transportation of YAP1 located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 upward arrow-->miR-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.
Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6, IKKepsilon and unanchored polyubiquitin chains.
The adaptor molecule RAIDD coordinates IKKepsilon and IRF7 interaction to ensure efficient expression of type I interferon.
These findings collectively support the conclusion that IKK modulates innate immune signaling cascades via phosphorylating the RIG-I cytosolic sensor, providing a feedback regulatory mechanism.
Blunting of NOX2-dependent IKKepsilon oncogenic kinase expression reduces proliferation and viability of human breast cancer cells.
IKKepsilon promotes NFATc1 phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 may contribute to the repression of energy expenditure during obesity.
A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB pathway by abolishing IKK-beta and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin and leptin resistance.
Data indicate the role for immune-response functions of IkappaBepsilon in B cells; it regulates proliferative capacity via at least two mechanisms involving cRel- and RelA-containing NF-kappaB dimers.
essential for signal transduction in Toll-like receptor-mediated glycolytic flux and dendritic cell activation
IKKepsilon knockout prevents high fat diet induced arterial atherosclerosis and NF-kappaB signaling in mice.
IKBKE regulates FOXO3a primarily through phosphorylation of SerS644
Sp1 is required for IL-15 induction by both poly(I:C) and respiratory syncytial virus, a response that also requires NFkappaB2 and IKKepsilon.
IKKvarepsilon might play an important role in ox-LDL-induced injury of endothelial cells.
IKKi deficiency exacerbates cardiac hypertrophy by regulating the AKT and NF-kappaB signaling pathway
Upon IL-1 stimulation, IKKi was activated to mediate GSK3alpha phosphorylation at S21.
Endotoxin uses a distinct pathway to initiate low-grade inflammation in macrophages, requiring interaction with IRAK-1 upstream of inducible kappa B kinase epsilon (inducible kappa B kinase epsilon) to contribute to the induction of C/EBPdelta and proinflammatory mediators.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase