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In conclusion, the spindle cell morphology should be induced by RelA (zeige NFkBP65 Proteine) activation (p-RelA (zeige NFkBP65 Proteine) S468) by IKKepsilon upregulation in human herpesvirus 8 vFLIP-expressing EA hy926 cells.
Studied association between nuclear factor kappa beta1/IKK epsilon (NF-kappaB1 (zeige NFKB1 Proteine)/IKKepsilon) gene expression and clinical activity in rheumatoid arthritis (RA). Found there were significant differences in NF-kappaB1 (zeige NFKB1 Proteine) and IKKepsilon gene expression (P = .001 and P = .029, respectively) between RA patients with clinical activity and clinical remission.
IKBKE plays a pivotal role in regulating cell proliferation, invasion and epithelial-mesenchymal transition of malignant glioma cells in vitro and in vivo by impacting on the Hippo pathway.
Inverse association between IKKepsilon and lymph node metastasis in breast cancer.
YPEL5 silencing enhanced the induction of IFNB1 (zeige IFNB1 Proteine) by pattern recognition receptors and phosphorylation of TBK1 (zeige TBK1 Proteine)/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
results demonstrate that Sphingosine 1-phosphate lyase (SPL (zeige SGPL1 Proteine)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (zeige SGPL1 Proteine), which provides a mechanistic understanding of the pro-IFN activity of SPL (zeige SGPL1 Proteine)
Virus-activated kinase IKKepsilon phosphorylated YAP (zeige YAP1 Proteine) at Ser403 and thereby triggered degradation of YAP (zeige YAP1 Proteine) in lysosomes and, consequently, relief of YAP (zeige YAP1 Proteine)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (zeige YAP1 Proteine) negatively regulates miR (zeige MLXIP Proteine)-let-7b/i by overexpressing and silencing YAP1 (zeige YAP1 Proteine) expression. In addition, miR (zeige MLXIP Proteine)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (zeige YAP1 Proteine) and suppresses the transportation of YAP1 (zeige YAP1 Proteine) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (zeige YAP1 Proteine) upward arrow-->miR (zeige MLXIP Proteine)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
IKKepsilon promotes NFATc1 (zeige NFATC1 Proteine) phosphorylation and inhibits T cell responses, identifying IKKepsilon as a crucial negative regulator of T cell activation and a potential target for immunotherapy.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 (zeige TBK1 Proteine) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (zeige APPL1 Proteine) in TLR3 (zeige TLR3 Proteine)/4-dependent TBK1 (zeige TBK1 Proteine) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (zeige ARNTL Proteine) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (zeige NLRP3 Proteine) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (zeige MLXIP Proteine)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (zeige NFKB1 Proteine) pathway by abolishing IKK-beta (zeige IKBKB Proteine) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase