anti-Maus Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
  • zgc:100844
  • IKBKE
  • MGC130907
  • IKK-E
  • IKK-i
  • IKKE
  • IKKI
  • AW558201
  • IKKepsilon
  • Ikki
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog
  • inhibitor of kappaB kinase epsilon
  • IKBKE
  • ikbke
  • ikbke.L
  • Ikbke
Epitop
AA 530-580
17
14
12
10
10
9
8
7
7
7
6
6
3
3
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
124
57
31
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
115
29
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
123
67
52
23
14
5
4
4
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen

Bilder

Produktnummer ABIN754033
$ 317.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
4 ABIN1387735 IF (p) IHC (p) WB Rabbit IgG pSer172 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754042 IHC (p) WB HRP Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754035 IHC (p) WB Biotin Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2894313 IHC IHC (p) WB Rabbit Anmelden zum Anzeigen Polyclonal 0
1 ABIN1735858 IHC (p) IP ELISA WB Rabbit IgG pThr500 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
Epitop AA 530-580
(17), (14), (12), (10), (10), (9), (8), (7), (7), (7), (6), (6), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(124), (57), (31), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(115), (29)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(123), (67), (52), (23), (14), (5), (4), (4), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IKBKE
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Ikbke (IKBKE Antibody Abstract)
Hintergrund

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Subcellular location: Cytoplasm, Nucleus

Synonyms: IKKE, IKKI, IKK-E, IKK-i, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, I-kappa-B kinase epsilon, IKK-epsilon, IkBKE, Inducible I kappa-B kinase, KIAA0151

Gen-ID 9641
UniProt Q14164
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (AA 530-580) antibody (ABIN754033) Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti IKBKE...