anti-Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
  • zgc:100844
  • IKBKE
  • MGC130907
  • IKK-E
  • IKK-i
  • IKKE
  • IKKI
  • AW558201
  • IKKepsilon
  • Ikki
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog
  • inhibitor of kappaB kinase epsilon
  • IKBKE
  • ikbke
  • ikbke.L
  • Ikbke
Epitop
pSer172
17
15
12
10
10
9
8
7
7
6
6
6
4
3
3
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
117
54
28
2
2
2
2
1
1
1
1
1
Wirt
Kaninchen
108
29
Klonalität
Polyklonal
Konjugat
Unkonjugiert
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
116
64
49
20
14
4
4
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN1387735
$ 328.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN754033 IF (p) IHC (p) WB Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN902020 IF (p) Alexa Fluor 488 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN902019 IF (p) Alexa Fluor 350 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN902022 IF (p) Alexa Fluor 647 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754037 IF (p) Cy5 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754036 IF (p) Cy3 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754039 IF (p) Cy7 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754038 IF (p) Cy5.5 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN754040 IF (p) FITC Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN902021 IF (p) Alexa Fluor 555 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN2814703 IF (p) Alexa Fluor 594 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5005220 IF (p) Alexa Fluor 750 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN5005219 IF (p) Alexa Fluor 680 Rabbit IgG AA 530-580 Anmelden zum Anzeigen Polyclonal 0
1 ABIN872297 IF (p) IHC (p) WB Rabbit IgG pThr501 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Antikörper
Epitop pSer172
(17), (15), (12), (10), (10), (9), (8), (7), (7), (6), (6), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(117), (54), (28), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Wirt Kaninchen
(108), (29)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(116), (64), (49), (20), (14), (4), (4), (2), (2), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synstic phosphopeptide derived from human IKKi/IKKE around the phosphorylation site of Ser172 [FV(p-S)VY]
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IKKi (IKBKE Antibody Abstract)
Hintergrund

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Synonyms: IKKE, IKKI, IKK-E, IKK-i, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, I-kappa-B kinase epsilon, IKK-epsilon, IkBKE, Inducible I kappa-B kinase, KIAA0151

Gen-ID 9641
UniProt Q14164
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Bilder zurück nach oben
Applikations-hinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN1387735) Mouse spleen cells probed with Rabbit Anti-IKKi(Ser172) Polyclonal Antibody at 1:100...