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Human CREB1 Protein expressed in Wheat germ - ABIN1350285
Yin, Li, Yang, Gao, Sun, Li: Detection of CREB phosphorylation via Zr (IV) ion mediated signal amplification. in Biosensors & bioelectronics 2014
CREB is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC.
The sequence of the CREB gene contains a 88 bp 5' UTR, a 783 bp open reading frame encoding 261 amino acids and a 348 bp 3' UTR.
Data indicate increasing expression for CREB, ATF1 (zeige AFT1 Proteine), and ATF3 (zeige ATF3 Proteine) during gastrulation.
Study suggest that both p300 (zeige EP300 Proteine) and CREB are required for the function integrity of HIF-1alpha (zeige HIF1A Proteine) transcription machinery and subsequent angiogenesis, suggesting future studies to improve burn wound healing might be directed to optimization of the interaction between p300 (zeige EP300 Proteine), CREB and HIF-1alpha (zeige HIF1A Proteine).
These findings suggest that CREB1 may be a potential therapeutic target for the treatment of gastric cancer
YAP (zeige YAP1 Proteine)/ TAZ (zeige TAZ Proteine) pathways contribute to the proliferation/quiescence switch during colon cancer 5FU treatment according to the concerted regulation of Cyclin E1 (zeige CCNE1 Proteine) and CREB
Data demonstrate that CREB is downregulated in glioma cells and is a direct target of miR (zeige MLXIP Proteine)-433-3p. These findings indicate that CREB subsequently directly or indirectly modulates its target genes to control the cell growth and metastasis in glioma.
these studies demonstrate that transcription factors CREB and c-Myc (zeige MYC Proteine) maintain the transcriptional activity of STING
GRK3 (zeige ADRBK2 Proteine) is a new critical activator of neuroendocrine phenotypes and mediator of CREB activation in promoting neuroendocrine differentiation of prostate cancer cells.
miR (zeige MLXIP Proteine)-150 is a novel Wnt (zeige WNT2 Proteine) effector that may significantly enhance epithelial-mesenchymal transition of colorectal cancer cells by targeting the CREB signaling pathway
fMRI and genotyping data from a large human sample, together with previous evidence, support the view that CREB1-associated mechanisms modulate brain function and behavior during reward-based decision-making.
Knockdown of either HIF-1 (zeige HIF1A Proteine) or CREB or both in hypoxia reduced the expression of hypoxia-response elements- and CRE-mediated gene expression, diminished cell proliferation and increased caspase-3 (zeige CASP3 Proteine) activity.
MnTE-2-PyP (zeige PPA1 Proteine) decreased p300 (zeige EP300 Proteine) complex binding to a specific HRE motif within the PAI-1 (zeige SERPINE1 Proteine) gene promoter region, suppressed H3K9 acetylation, and consequently, repressed PAI-1 (zeige SERPINE1 Proteine) expression. Mechanistically, less p300 (zeige EP300 Proteine) transcriptional complex binding is not due to the reduction of binding between p300 (zeige EP300 Proteine) and HIF-1 (zeige HIF1A Proteine)/CREB transcription factors, but through inhibiting the binding of HIF-1 (zeige HIF1A Proteine)/CREB transcription factors to DNA
phosphorylation of CREB is downregulated in the Muller glia.
Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling.
Both CREB and deltaFosB play a role in the induction of this behavioural sensitization.
astrocytic IL-17A (zeige IL17A Proteine) plays important roles in the maintenance of neuropathic pain through CaMKII (zeige CAMK2G Proteine)/CREB signaling pathway in spinal cord.
LH induces MAPK3 (zeige MAPK3 Proteine)/1 and Akt (zeige AKT1 Proteine) activation, both of which are required for the CREB-promoted expression of EGF (zeige EGF Proteine)-like factors in granulosa cells.
However, the mechanism that induces release of IL-6 (zeige IL6 Proteine) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (zeige IL6 Proteine) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
NFIL3 (zeige NFIL3 Proteine) functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis
EGCG significantly ameliorated insulin (zeige INS Proteine) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1 (zeige IRS1 Proteine))/AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (zeige BDNF Proteine)) signaling pathways.
Ca(2 (zeige CA2 Proteine)+) signaling pathway increases Nr4a1 (zeige NR4A1 Proteine) expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (zeige MEF2C Proteine), AP1 (zeige JUN Proteine), and CREB transcription factors thus demonstrating an important interplay between the Ca(2 (zeige CA2 Proteine)+) and cAMP pathways in regulating Nr4a1 (zeige NR4A1 Proteine) expression.
PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway.
The expression of porcine Prdx6 (zeige PRDX6 Proteine) gene is up-regulated by C/EBPbeta (zeige CEBPB Proteine) and CREB.
Results suggest that cerebral hypoxia results in differential regulation of CREB protein-mediated expression of proapoptotic and antiapoptotic proteins in the cerebral cortex of newborn piglets.
Data indicate that Ser738/742-to-glutamate (zeige GRIN2A Proteine) protein kinase D (zeige PRKD1 Proteine) mutant increased AngII-induced CREB protein and activating transcription factor 2 (zeige ATF2 Proteine) phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein (zeige STAR Proteine) promoter.
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia.
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 (zeige LYPLA1 Proteine)
the p38-MAPK (zeige MAPK14 Proteine)/CREB pathway plays a critical role in TNFalpha (zeige TNF Proteine)-induced VCAM-1 (zeige VCAM1 Proteine) expression
We found several conserved cis elements in the frog CRF genes including a cAMP response element (CRE), activator protein 1 binding sites, and glucocorticoid response elements
p38 MAPK (zeige MAPK14 Proteine) and CREB function along the dorsal-ventral axis in mesoderm patterning. The phosphorylated form of CREB (S133) is distributed in a gradient along the dorsal-ventral mesoderm axis and the p38 MAPK (zeige MAPK14 Proteine) pathway mediates the phosphorylation of CREB.
modulating CREB activity during early zebrafish development caused significant defects in neural proliferation, midbrain-hindbrain organization and body patterning
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
cAMP responsive element binding protein 1
, cAMP responsive element binding protein
, cyclic AMP-responsive element-binding protein 1
, active transcription factor CREB
, cAMP-response element-binding protein-1
, cAMP-responsive element-binding protein 1
, transactivator protein
, Y protein
, cAMP response element binding protein 1
, cAMP response element-binding protein
, cyclic AMP-responsive element binding protein, delta
, cyclic AMP-responsive DNA-binding protein