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Human CD36 Protein expressed in Human Cells - ABIN2003345
Xu, Efremov, Li, Lai, Dao, Lim, Cao: Probing the cytoadherence of malaria infected red blood cells under flow. in PLoS ONE 2013
genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (zeige TAS1R2 Proteine) (rs35874116), and TAS2R38 (zeige TAS2R38 Proteine) (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS]
CD36 is important for muscle glucose metabolism and optimal insulin (zeige INS Proteine) responsiveness.
Significant up-regulation of PBMCs CAP1 (zeige PRSS8 Proteine), CD36 mRNA and plasma resistin (zeige RETN Proteine) found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin (zeige RETN Proteine) could be able to exert its effects stronger on cells with up-regulated CAP1 (zeige PRSS8 Proteine) mRNA thus contributing atherosclerosis development.
CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs (zeige FAS Proteine), is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 (zeige SCD Proteine) inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells
Results showed that CD36 genotypes were not associated with the progression to T2DM independently. however, the study suggested a positive interaction between the CD36 variants and obesity on T2DM susceptibility, which might be through a cardiometabolic disorder.
Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with intracerebral hemorrhage, and genotype GG could be an independent predictor.
CD36 marks adipocyte progenitor cells with pronounced adipogenic potential, most probably by facilitating lipid uptake.
sCD36 levels increased with the level of intrahepatic lipid, insulin (zeige INS Proteine) resistance and dyslipidemia; association with markers of obesity and the association with hepatic CD36 mRNA expression suggest that excess sCD36 in NAFLD patients is derived from the hepatocytes, which may support that CD36 is involved in NAFLD development; an unhealthy CD36 expression in adipose and hepatic tissue may shift the fatty-acid load to liver
In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits beta-catenin (zeige CTNNB1 Proteine) to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages.
Based on these findings, we conclude that an acetylation-deacetylation signaling step might regulate CD36 functional activity and subsequent lipid accumulation and caspase 3 (zeige CASP3 Proteine) activation in pancreatic beta cells exposed to GLT (zeige SLC1A2 Proteine) conditions.
Amyloid-beta inhibits No-cGMP signaling in a CD36- and CD47 (zeige CD47 Proteine)-dependent manner
Niacin Reduces serum level and adipose mRNA expression of leptin (zeige LEP Proteine) and up-regulates PPARgamma (zeige PPARG Proteine) and CD36 mRNA expression in hypercholesterolemic rabbits.
Overexpressing STAMP2 (zeige STEAP4 Proteine) attenuates adipose tissue angiogenesis and insulin (zeige INS Proteine) resistance in diabetic ApoE (zeige APOE Proteine)(-/-) /LDLR (zeige LDLR Proteine)(-/-) mouse via a PPARgamma (zeige PPARG Proteine)/CD36 pathway.
This study demonstrated the CD36 deletion in mice (CD36(-/-) mice) resulted in an attenuated progression of chronic epilepsy compared with wild-type (WT) mice.
TMP upregulated the protein stability of ABCA1 (zeige ABCA1 Proteine) without affecting ABCG1 (zeige ABCG1 Proteine). Accordingly, TMP regulated the expression of SR-A (zeige MSR1 Proteine), CD36, ABCA1 (zeige ABCA1 Proteine) and ABCG1 (zeige ABCG1 Proteine) in aortas of ApoE (zeige APOE Proteine)-/- mice, which resembled the findings observed in macrophages.
atherogenic condition could activate eosinophils and modulate the phenotype of macrophages (from M2 to M1 phenotype), in part, through the CD36 receptor signaling
CD36 plays a role in the perception of specific odour-active volatile compounds in the nasal cavity.
CD36 plays an important role in modifying gallstone susceptibility in mice
CD36 is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR (zeige PPARA Proteine))-related transcriptional responses in the muscle with exercise training.
development of obesity-related chronic kidney disease via CD36 in mice
The low magnitude of opsonin-independent phagocytosis of Escherichia coli and unimpaired phagocytosis of Staphylococcus aureus in SR-A (zeige MSR1 Proteine)- or CD36-deficient macrophages indicate that the defect in this process might not be responsible for the reported impaired bacteria clearance in mice deficient in these receptors.
These results suggest that increased expression of hepatic CD36 and SREBP-1 (zeige SREBF1 Proteine) is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Gammadelta T cells express CD36 and it contributes to responses by these cells to microbial lipoteichoic acid.
The findings of this study indicated that Cd36 is a candidate lipid sensor involved in the sensory detection of fatty acid in zebrafish.
Zebrafish Cd36 is a microbial-binding molecule.
The putative role for Cd36 in immune responses of fish in the context of other members of the scavenger receptor class B family, is discussed.
CD36 plays a vital role in the LPS (zeige IRF6 Proteine)-induced activation of downstream signaling cascades and mediates E. coli phagocytosis via TLR4 (zeige TLR4 Proteine) in pGMECs, which offers a novel treatment strategy for mastitis
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
CD36 antigen (collagen type I receptor, thrombospondin receptor)
, PAS IV
, PAS-4 protein
, cluster determinant 36
, fatty acid translocase
, glycoprotein IIIb
, leukocyte differentiation antigen CD36
, platelet glycoprotein 4
, platelet glycoprotein IV
, scavenger receptor class B, member 3
, adipocyte membrane protein
, collagen type I receptor thrombospondin receptor
, fatty acid transport protein
, fatty acid translocase/CD36
, CD36 antigen
, collagen type I receptor, thrombospondin receptor