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Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686700
Yang, Turner, Gaut: The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. in The Journal of biological chemistry 1998
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Human GRP78 Protein expressed in Escherichia coli (E. coli) - ABIN1686682
Rechthand, Smith, Latker, Rapoport: Altered blood-nerve barrier permeability to small molecules in experimental diabetes mellitus. in Journal of neuropathology and experimental neurology 1987
Show all 9 Pubmed References
Human GRP78 Protein expressed in Wheat germ - ABIN1307202
Taylor, Gercel-Taylor, Parker: Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer. in Gynecologic oncology 2009
In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.
Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
Cell surface GRP78 promotes cancer stemness, whereas drives cells toward a non-stemlike phenotype when it chaperones Progranulin (zeige GRN Proteine).
We showed that GRP78 is elevated in diabetic macular edema patients. In addition, there is a correlation between GRP78 and VEGF (zeige VEGFA Proteine) levels in aqueous humor. However, GRP78 levels were not associated with the responsiveness of anti-VEGF (zeige VEGFA Proteine) in diabetic macular edema patients.
Data suggest that prostatic tumor GRP78 expression correlates with disease stage; anti-GRP78 autoantibody levels parallel prostate-specific antigen concentrations in patient-derived serum samples.
High GRP78 expression is associated with radioresistance in nasopharyngeal carcinoma.
Data suggest a complex but functional interplay of ER chaperone GRP78 and steroid hormones, working together for cell survival and proliferation in the context of reproduction.
the physiological role played by the complex KCTD15-GRP78 in the adipogenesis
Concomitant high expression of ERalpha36, GRP78 and GRP94 (zeige HSP90B1 Proteine) is associated with aggressive papillary thyroid cancer behavior and may be used as a predictor for extrathyroid extension, lymph node metastasis, and distant metastasis.
We found that downregulation of GRP78 led to inhibition of autophagy, cell cycle arrest in the G0/G1 phase, and activation of caspase-7 (zeige CASP7 Proteine)-induced apoptosis, and this was affected by the initial autophagy level.
GRP78 promotes cigarette smoke-induced inflammatory response and mucus hyperproduction in airway epithelial cells, likely through upregulation of necroptosis and subsequent activation of NF-kappaB (zeige NFKB1 Proteine) and AP-1 (zeige FOSB Proteine) pathways.
Data suggested that GRP78 silencing increased chemo-sensitivity and improved the effects of cisplatin-induced apoptosis in SiHa cells. Moreover, inhibition of GRP78 could upregulate caspase-3 (zeige CASP3 Proteine) and CHOP (zeige DDIT3 Proteine) expression and downregulate Bcl-2 (zeige BCL2 Proteine) expression.
This paper reports the localization of both GRP78 and HSP60 (zeige HSPD1 Proteine) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (zeige HSPD1 Proteine) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
Over-expression of GRP78 enhances replication of Porcine Circovirus 2.
These results uncover a novel role of GRP78 in reducing prion (zeige PRNP Proteine) pathogenesis, suggesting that modulating its levels/activity may offer a novel opportunity for designing therapeutic approaches for these diseases.
Endoplasmic reticulum stress leads to de novo biosynthesis of non-trimethylated GRP78, whereas homeostatic, METTL21A (zeige FAM119A Proteine)-dependent lysine 585-trimethylated GRP78 is reduced.
GRP78 haploinsufficiency for up to 2 years of age has no major deleterious effect in rodents of different genetic background.
GRP78 promotes cigarette smoke-induced inflammatory response and mucus hyperproduction in airway epithelial cells, likely through upregulation of necroptosis and subsequent activation of NF-kappaB (zeige NFKB1 Proteine) and AP-1 (zeige JUN Proteine) pathways.
siRNA of Grp78 disturbed the fusion of mouse palate cultured in vitro, suggesting a role in the palate development during embryogenesis..
prolonged endoplasmic reticulum stress promotes apoptosis via a p53 (zeige TP53 Proteine)-dependent inhibition of BiP expression
analysis of the effects of triptolide on cell proliferation, cell cycle and the expression of GRP78 in nasopharyngeal carcinoma
candidate genes that modulate Hspa5 expression in the retina, were examined.
These results indicate that GRP78, but not nutritional status, is a potent up-regulator of hepatic PTC (zeige PTCH1 Proteine)-mRNA levels during induction of ER stress in vivo.
Data suggest that activation of GRP78/Ire1 (zeige ERN1 Proteine)/Xbp1 (zeige XBP1 Proteine) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide