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anti-Human GRP78 Antikörper:
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Chicken Polyclonal GRP78 Primary Antibody für FACS, ICC - ABIN446401
Pepping, Freeman, Gupta, Keller, Bruce-Keller: NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. in American journal of physiology. Endocrinology and metabolism 2013
Show all 15 Pubmed References
Human Polyclonal GRP78 Primary Antibody für IF (cc), IF (p) - ABIN673554
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 4 Pubmed References
Human Polyclonal GRP78 Primary Antibody für ELISA, ICC - ABIN6262100
Li, Yang, Li, Liu, Wang, Guo, Tan, Gao, Zhao, Zhang, Gou, Yokota, Zhang: Role of endoplasmic reticulum stress in disuse osteoporosis. in Bone 2017
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Human Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN152679
Shin, Feltri, Wrabetz: Altered Trafficking and Processing of GALC Mutants Correlates with Globoid Cell Leukodystrophy Severity. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
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Human Monoclonal GRP78 Primary Antibody für IHC, ELISA - ABIN969204
Honda, Horie, Daito, Ikuta, Tomonaga: Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. in Journal of virology 2009
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Human Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN4316288
Sharma, Masri, Jo, Bernath, Martin, Funk, Gera: Protein kinase C regulates internal initiation of translation of the GATA-4 mRNA following vasopressin-induced hypertrophy of cardiac myocytes. in The Journal of biological chemistry 2007
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Human Polyclonal GRP78 Primary Antibody für ELISA, WB - ABIN561386
Lindenmeyer, Rastaldi, Ikehata, Neusser, Kretzler, Cohen, Schlöndorff: Proteinuria and hyperglycemia induce endoplasmic reticulum stress. in Journal of the American Society of Nephrology : JASN 2008
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Cow (Bovine) Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN361825
Luo, Mao, Lee, Lee: GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. in Molecular and cellular biology 2006
Show all 10 Pubmed References
Dog (Canine) Polyclonal GRP78 Primary Antibody für ICC, IF - ABIN863190
Cho, Park, Kim, Kim, Kim, Jang: BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1. in Molecular and cellular biology 2006
Show all 9 Pubmed References
Human Polyclonal GRP78 Primary Antibody für WB - ABIN2801942
Ting, Lee: Human gene encoding the 78,000-dalton glucose-regulated protein and its pseudogene: structure, conservation, and regulation. in DNA (Mary Ann Liebert, Inc.) 1988
In amphibians, the association of BiP with unfolded protein and its possible role in aggresome function may be vital in the maintenance of cellular proteostasis.
Hspa5 is essential for pronephros formation by mediating retinoic acid signaling.
We found that downregulation of GRP78 led to inhibition of autophagy, cell cycle arrest in the G0/G1 phase, and activation of caspase-7 (zeige CASP7 Antikörper)-induced apoptosis, and this was affected by the initial autophagy level.
GRP78 promotes cigarette smoke-induced inflammatory response and mucus hyperproduction in airway epithelial cells, likely through upregulation of necroptosis and subsequent activation of NF-kappaB (zeige NFKB1 Antikörper) and AP-1 (zeige FOSB Antikörper) pathways.
Data suggested that GRP78 silencing increased chemo-sensitivity and improved the effects of cisplatin-induced apoptosis in SiHa cells. Moreover, inhibition of GRP78 could upregulate caspase-3 (zeige CASP3 Antikörper) and CHOP (zeige DDIT3 Antikörper) expression and downregulate Bcl-2 (zeige BCL2 Antikörper) expression.
Upon IgM expression, its levels temporarily eclipse those of the endoplasmic reticulum chaperone BiP (zeige GDF10 Antikörper), leading to acute, full-geared unfolded protein response activation. Once BiP (zeige GDF10 Antikörper) is in excess (zeige RCC1 Antikörper) again, the unfolded protein response transitions to chronic, submaximal activation, indicating that the unfolded protein response senses endoplasmic reticulum stress in a ratiometric fashion.
GRP78 binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109 (zeige CD109 Antikörper), in blocking TGF-beta (zeige TGFB1 Antikörper) signaling by promoting the routing of the TGF-beta (zeige TGFB1 Antikörper) receptor to the caveolae, thereby disrupting its binding to and activation of Smad2 (zeige SMAD2 Antikörper).
this study demonstrates the reaction of placental GRP78 with sera from women with multiple sclerosis
This meta-analysis shows that BiP (zeige GDF10 Antikörper) or anti-BiP (zeige GDF10 Antikörper) antibodies have a moderate accuracy for the diagnosis of rheumatoid arthritis with a moderate sensitivity and high specificity. It can be an efficient supplement to the existing diagnostic method. [Meta-Analysis]
the expression of three cytokines for the pathogenesis of osteoarthritis (OA). which include IL-1beta (zeige IL1B Antikörper), MMP14 (zeige MMP14 Antikörper) and GRP78 was decreased by the various concentrations of icariin. These preliminary results imply that icariin might be an effective compound for the treatment of OA disease.
In a retrospective cervical cancer cohort, high GRP78 expression was correlated with poor survival. miR (zeige MLXIP Antikörper)-181a suppressed cervical cancer development via downregulating GRP78.
We revealed that DAL-1 (zeige EPB41L3 Antikörper) was downregulated while HSPA5 was upregulated in NSCLC and found the protein of DAL-1 (zeige EPB41L3 Antikörper) and HSPA5 co-localized in the cytoplasm and nucleus. We demonstrated that DAL-1 (zeige EPB41L3 Antikörper) can suppress the expression of HSPA5 on mRNA and protein levels, and decrease EMT (zeige ITK Antikörper), migration, invasion and proliferation abilities by down-regulating HSPA5
This paper reports the localization of both GRP78 and HSP60 (zeige HSPD1 Antikörper) on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 (zeige HSPD1 Antikörper) in the sperm midpiece.
BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death
Over-expression of GRP78 enhances replication of Porcine Circovirus 2.
GRP78 promotes cigarette smoke-induced inflammatory response and mucus hyperproduction in airway epithelial cells, likely through upregulation of necroptosis and subsequent activation of NF-kappaB (zeige NFKB1 Antikörper) and AP-1 (zeige JUN Antikörper) pathways.
siRNA of Grp78 disturbed the fusion of mouse palate cultured in vitro, suggesting a role in the palate development during embryogenesis..
prolonged endoplasmic reticulum stress promotes apoptosis via a p53 (zeige TP53 Antikörper)-dependent inhibition of BiP expression
analysis of the effects of triptolide on cell proliferation, cell cycle and the expression of GRP78 in nasopharyngeal carcinoma
candidate genes that modulate Hspa5 expression in the retina, were examined.
These results indicate that GRP78, but not nutritional status, is a potent up-regulator of hepatic PTC (zeige PTCH1 Antikörper)-mRNA levels during induction of ER stress in vivo.
Data suggest that activation of GRP78/Ire1 (zeige ERN1 Antikörper)/Xbp1 (zeige XBP1 Antikörper) pathway of ER stress-unfolded protein response is involved in mouse decidualization.
Upregulating HSF1 (zeige HSF1 Antikörper) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP (zeige DDIT3 Antikörper) and increasing HSP70 (zeige HSP70 Antikörper) a5 (BiP/GRP78). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (zeige HSF1 Antikörper) being one likely key player in both systems.
These results demonstrate a key role for GRP78 in alveolar epithelial cell survival.
These results indicate that GRP78, an endoplasmic reticulum chaperon of the HSP70 (zeige HSP70 Antikörper) family, is a novel host factor involved at multiple steps of the Japanese encephalitis virus life cycle and could be a potential therapeutic target.
Phosphatidylinositol deficient zebrafish have elevated hspa5 expression in the liver and hepatic lipid accumulation due to endoplasmic reticulum stress response.
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.
78 kDa glucose-regulated protein
, heat shock 70 kDa protein 5
, Protein 1603
, 78 kDa glucose-regulated protein homolog
, luminal-binding protein
, glucose-regulated protein 78
, glucose-regulated protein 78kDa
, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
, GRP 78
, heavy-chain binding protein BiP
, immunoglobulin heavy chain-binding protein
, endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
, glucose-regulated protein, 78kDa
, XAP-1 antigen
, glucose regulated protein, 78 kDa
, heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
, heat shock 70kD protein 5
, heat shock 70kDa protein 5 (glucose-regulated protein)
, steroidogenesis-activator polypeptide