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Parathyroid hormone (zeige PTH Proteine) controls bone and kidney homeostasis via GNAS and Gq-G11 (zeige STK19 Proteine) heterotrimeric G proteins. (Review)
GIV is a bifunctional modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas using the same motif that allows it to serve as a guanine-nucleotide exchange factor (zeige RASGRF1 Proteine) for Galphai
GNAS harbors 2 SNPs that were associated with an increased risk for ventricular tachyarrhythmia in implantable cardioverter defibrillator patients, of which 1 was successfully replicated in a community-based population of sudden cardiac death cases.
RAS and GNAS mutations were associated with worse progression-free survival (PFS) at univariate analysis (P = 0.006 and 0.011, respectively). At multivariate analysis, only KRAS mutations were independently associated with PFS (P = 0.012); GNAS mutations were not-being significantly associated with other poor prognostic features such as incomplete cytoreduction or KRAS mutations
Ectopic expression of the human gain-of-function mutation GNAS(R201C) in mice supported transplantable HSC (zeige FUT1 Proteine) activity and improved lymphoid output in secondary recipients. Because declining lymphoid output is a hallmark of aging, GNAS(R201C) mutations may sustain lymphoid-biased HSCs over time and maintain them in a developmental state favorable for transformation.
This is the first report to show that PLEKHG2 (zeige PLEKHG2 Proteine) is a novel effector of Galphas, and is negatively regulated by the Galphas subunit through direct interaction.
The presence of a mutation in GNAS is helpful in identifying a mucin (zeige SLC13A2 Proteine)-producing Pancreatic cyst and is found in more than 90% of Intraductal Papillary Mucinous Pancreas Neoplasms .
pseudomyxoma peritonei patients with GNAS mutations had a significantly shorter median progression-free survival as compared to GNAS wild-type ones.
GNAS mutation is associated with gastric cancer.
Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells.
The Galphas and Galphaq (zeige GNAQ Proteine) peptides adopt different orientations in beta2-AR and V1AR (zeige AVPR1A Proteine), respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR (zeige AVPR1A Proteine)/Galphaq (zeige GNAQ Proteine) peptide interactions are predominantly hydrophobic.
Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2 (zeige BCL2 Proteine), Fas (zeige FAS Proteine), and Caspase-3 (zeige CASP3 Proteine), which are recognized as apoptosis related markers.
study did not find any significant associations for polymorphisms in insulin (zeige INS Proteine)-like grwoth factor 2, GTP Binding Protein (zeige RND1 Proteine) alpha Subunits, Gs and melanocortin receptor 4 (zeige MC4R Proteine) genes with reproductive traits of Polish Landrace and Large White pigs
Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.
Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.
Review article on the human GNAS complex locus.
Our data revealed a positive correlation between hepatic Gsalpha-cAMP signal axis and fasting blood glucose (FBG) in slight insulin (zeige INS Proteine) resistance stage of HIgh Sugar High Fat-diet rats and diabetic db/db (zeige LEPR Proteine) mice. The current finding thus suggested hepatic Gsalpha-cAMP signal axis plays a central role in regulating of FBG during the developing and development of T2DM.
in colonic crypt cultures, the GLP-1 secretion induced by such Gq + Gs GPR40 agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
retrograde trafficking to the trans-Golgi network induces local Gs-protein activation and cAMP/PKA signaling at a critical position near the nucleus, which appears required for efficient CREB (zeige CREB1 Proteine) phosphorylation and gene transcription
results show that most of the PatDp(dist2) phenotype is due to overexpression of Gnasxl combined with loss of expression of Gnas, and suggest that Gnasxl and Gnas may act antagonistically in a number of tissues and to cause a wide range of phenotypic effects
results suggest that the T1R3 (zeige TAS1R3 Proteine) homomeric sweet taste receptor negatively regulates adipogenesis through Galphas-mediated microtubule disassembly and consequent activation of the Rho/ROCK pathway.
results show that Gsalpha imprinting in the dorsomedial nucleus of the hypothalamus (DMH (zeige DST Proteine)) underlies the parent-of-origin metabolic phenotype that results from Gsalpha mutations and that DMH (zeige DST Proteine) MC4R (zeige MC4R Proteine)/Gsalpha signaling is important for regulation of energy expenditure and brown adipose tissue activation, but not the metabolic response to cold.
activating mutations in GNAS and Kras cooperatively promote murine pancreatic tumorigenesis
Authors demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 (zeige TPH2 Proteine) and Slc6a4 (zeige SLC6A4 Proteine), but not the dopamine-specific gene Th in Nesp(m/+) mice.
Disruption of Gnas in smooth muscle of mice reduced intestinal motility and led to death within 4 weeks. GNAS disruption in adults impaired contraction of intestinal smooth muscle and peristalsis with features of intestinal pseudo-obstruction characterized by chronic intestinal dilation and dysmotility.
Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.
application of peptide amide hydrogen-deuterium exchange mass spectrometry to probe changes in the structure of the heterotrimeric bovine G protein, Gs on formation of a complex with agonist-bound human beta(2) adrenergic receptor (zeige ADRB2 Proteine)
crystal structure of the active state ternary complex composed of agonist-occupied monomeric beta2 adrenergic receptor (zeige ADRB2 Proteine) and nucleotide-free Gs heterotrimer
the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex
a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.
adenylate cyclase-stimulating G alpha protein
, alternative gene product encoded by XL-exon
, extra large alphas protein
, guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
, guanine nucleotide regulatory protein
, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
, neuroendocrine secretory protein
, protein ALEX
, secretogranin VI
, GNAS complex locus
, GTP-binding regulatory protein alpha subunit exon 1
, guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
, guanine nucleotide-binding protein G(s) subunit alpha
, stimulatory GTP binding protein
, Galpha olf1
, guanine nucleotide-binding protein G(olf) subunit alpha
, alpha-stimulatory subunit of GTP-binding protein
, guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
, Gs alpha subunit
, neuroendocrine secretory protein 55
, stimulatory G-protein alpha subunit
, guanine nucleotide-binding protein G(s) subunit alpha isoforms
, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
, guanine nucleotide binding protein alpha s
, guanine nucleotide-binding protein G-s, alpha subunit
, guanine nucleotide binding protein, alpha stimulating, olfactory type
, guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like
, Galpha s