anti-Pferd VAV1 Antikörper für Western Blotting

Recommended VAV1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Vav 1 Oncogene (VAV1) Antikörper
  • VAV
  • Vav
  • vav-T
  • vav guanine nucleotide exchange factor 1
  • vav 1 oncogene
  • vav guanine nucleotide exchange factor 1 L homeolog
  • VAV1
  • Vav1
  • vav1.L
Epitop
Middle Region
37
25
22
22
15
10
9
8
6
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
183
75
74
3
3
2
2
1
1
Wirt
Kaninchen
133
51
Klonalität
Polyklonal
Konjugat
Dieser VAV1 Antikörper ist unkonjugiert
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
156
72
26
24
14
14
11
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2792554
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN229275 WB Rabbit IgG AA 581-596 Anmelden zum Anzeigen Polyclonal 0
1 ABIN598392 WB Rabbit IgG pTyr174 Anmelden zum Anzeigen Polyclonal 0
1 ABIN598393 WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Vav 1 Oncogene (VAV1) Antikörper
Epitop Middle Region
(37), (25), (22), (22), (15), (10), (9), (8), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Pferd, Human, Maus, Schwein, Kaninchen, Ratte (Rattus)
(183), (75), (74), (3), (3), (2), (2), (1), (1)
Wirt Kaninchen
(133), (51)
Klonalität
Polyklonal
Konjugat Dieser VAV1 Antikörper ist unkonjugiert
(5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Western Blotting (WB)
(156), (72), (26), (24), (14), (14), (11), (4), (3), (2), (1), (1), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-VAV1 Antikörper

Target Details VAV1 Anwendungsinformationen Handhabung Referenzen für anti-VAV1 Antikörper (ABIN2792554) Bilder
Sequenz RDRSELSLKE GDIIKILNKK GQQGWWRGEI YGRVGWFPAN YVEEDYSEYC
Kreuzreaktivität Rind (Kuh), Hund, Human, Maus, Ratte (Rattus)
Homologie Cow: 92%, Dog: 92%, Horse: 92%, Human: 100%, Mouse: 92%, Pig: 92%, Rabbit: 90%, Rat: 92%
Produktmerkmale This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human VAV1

Target Details VAV1

Produktdetails anti-VAV1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-VAV1 Antikörper (ABIN2792554) Bilder zurück nach oben
Antigen
Andere Bezeichnung VAV1 (VAV1 Antibody Abstract)
Hintergrund This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: VAV
Protein Interaction Partner: UBC, CD28, ERBB3, ERBB2, EGFR, PTPN22, SPI1, PLCG1, Mbp, CD5, PDGFRB, NOTCH1, FGFR1, DOK1, TUBB, SH3BP2, CBLB, CBL, FYN, SYK, LCP2, CD19, SOCS1, KHDRBS1, LMNA, TUBA1A, PHAX, ZAP70, ZNF655, DOCK2, XRCC5, PAG1, RACGAP1, MERTK, BLNK, NEK3, AOC3, ARHGDIB, DNM
Protein Size: 845
Molekulargewicht 98 kDa
Gen-ID 7409
NCBI Accession NM_005428, NP_005419
UniProt P15498
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, CXCR4-mediated Signaling Events

Anwendungsinformationen

Produktdetails anti-VAV1 Antikörper Target Details VAV1 Handhabung Referenzen für anti-VAV1 Antikörper (ABIN2792554) Bilder zurück nach oben
Applikationshinweise WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:62500
Positive Control: Human heart.
Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 845 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-VAV1 Antikörper Target Details VAV1 Anwendungsinformationen Referenzen für anti-VAV1 Antikörper (ABIN2792554) Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-VAV1 Antikörper (ABIN2792554)

Produktdetails anti-VAV1 Antikörper Target Details VAV1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Schneider, Rudd: "CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription." in: Biochemical and biophysical research communications, Vol. 369, Issue 2, pp. 616-21, 2008

Bilder

Produktdetails anti-VAV1 Antikörper Target Details VAV1 Anwendungsinformationen Handhabung Referenzen für anti-VAV1 Antikörper (ABIN2792554) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Vav 1 Oncogene (VAV1) (Middle Region) antibody (ABIN2792554) WB Suggested Anti-VAV1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...