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anti-Human STIM1 Antikörper:
anti-Mouse (Murine) STIM1 Antikörper:
anti-Rat (Rattus) STIM1 Antikörper:
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Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN563045
Grosse, Braun, Varga-Szabo, Beyersdorf, Schneider, Zeitlmann, Hanke, Schropp, Mühlstedt, Zorn, Huber, Schmittwolf, Jagla, Yu, Kerkau, Schulze, Nehls, Nieswandt: An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. in The Journal of clinical investigation 2007
Show all 20 Pubmed References
Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1003211
Luik, Lewis: New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells. in Trends in molecular medicine 2007
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Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1030706
Shen, Zhu, Zhang, Jiang, Wang, Zhang, Li, Huang, Ke, Ma, Du: Attenuated mesangial cell proliferation related to store-operated Ca(2+) entry in aged rat: the role of STIM 1 and Orai 1. in Age (Dordrecht, Netherlands) 2013
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Human Monoclonal STIM1 Primary Antibody für ICC, IHC (p) - ABIN192394
Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume: Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. in American journal of physiology. Cell physiology 2010
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Cow (Bovine) Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN258795
Meuchel, Stewart, Smelter, Abcejo, Thompson, Zaidi, Martin, Prakash: Neurokinin-neurotrophin interactions in airway smooth muscle. in American journal of physiology. Lung cellular and molecular physiology 2011
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Human Monoclonal STIM1 Primary Antibody für ICC, IF - ABIN188961
Williams, Manji, Parker, Hancock, Van Stekelenburg, Eid, Senior, Kazenwadel, Shandala, Saint, Smith, Dziadek: Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. in The Biochemical journal 2001
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Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN2476609
Varga-Szabo, Braun, Kleinschnitz, Bender, Pleines, Pham, Renné, Stoll, Nieswandt: The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. in The Journal of experimental medicine 2008
Human Monoclonal STIM1 Primary Antibody für ELISA, IF - ABIN396503
Verma, Hoffmann, Kumar, Huang, Roe, Nguyen-Wu, Hashimoto, Hoffmann: Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN4356540
Wang, Choi, Richardson, Reid, Seymen, Yildirim, Tuna, Gençay, Simmer, Hu: STIM1 and SLC24A4 Are Critical for Enamel Maturation. in Journal of dental research 2015
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (zeige CA2 Antikörper)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (zeige CA2 Antikörper)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (zeige CA2 Antikörper)+) entry
STIM1 plays role in PAR1 (zeige F2R Antikörper)-mediated Ca2 (zeige CA2 Antikörper)+ influx and Ca2 (zeige CA2 Antikörper)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
Stim1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (zeige TRPC1 Antikörper)-dependent store-operated Ca2 (zeige CA2 Antikörper)+ entry plays an essential role in generating spatiotemporal Ca2 (zeige CA2 Antikörper)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (zeige ORAI1 Antikörper) are essential components of the signal transduction cascade that regulates sex pheromone production.
The phosphorylation of the T389 residue in STIM1 is an essential feature determining the activity of store-independent ARC (zeige NOL3 Antikörper) channels, and is mediated by an AKAP79 (zeige AKAP5 Antikörper)/PKA-dependent process.
An Orai1 (zeige ORAI1 Antikörper) C-terminal STIM1-binding site, situated far from the N-terminal pore helix, alone provides the trigger that is necessary and sufficient for channel gating.
Stim1 silencing also reduced cell viability, caused cell apoptosis and cell cycle arrest in Multiple myeloma cell lines.
Study shows that STIM1 and ORAI1 (zeige ORAI1 Antikörper) promotes membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and ORAI1 (zeige ORAI1 Antikörper) co-localize with cortactin (zeige CTTN Antikörper).
Results show that STIM1 is overexpressed in prostate cancer tissues and, reveal that it may act as a novel regulator of migration and invasion of prostate cancer cells through the activation of the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) signaling pathway.
In patients with ORAI1 (zeige ORAI1 Antikörper) and STIM1 loss of function mutations, effector functions were preserved in polymorphonuclear neutrophils.
This activation was sensitive to Src kinase (zeige CSK Antikörper) inhibition, but not to CAMKII (zeige CAMK2G Antikörper) nor PKC (zeige PRRT2 Antikörper) inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src (zeige SRC Antikörper)-Raf (zeige RAF1 Antikörper)-MEK (zeige MAP2K1 Antikörper)-ERK (zeige EPHB2 Antikörper), rather than upstream regulators.
STIM1 plays an important role in paraquat induced cell cycle arrest and cell death in acute lung injury.
we demonstrated that STIM1 could be involved in breast tumorigenesis and progression
Study provide clear evidence that STIM1 has a cholesterol-binding domain located inside the SOAR region and modulates Orai1 (zeige ORAI1 Antikörper) channels. A functional association of STIM1 and SOAR to cholesterol was shown, indicating a close proximity of SOAR to the inner layer of the plasma membrane. In contrast, the depletion of cholesterol induces the SOAR detachment from the plasma membrane and enhances its association to Orai1 (zeige ORAI1 Antikörper).
STIM1 and STIM2 (zeige Stim2 Antikörper) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (zeige ITPR1 Antikörper).
Stim1 promotes cross-presentation of phagocytosed antigens in dendritic cells.Stim1 role in Calcium signaling.Stim1 is dispensable for dendritic cells maturation and phagocytosis.
SOCE was largely diminished in cells where STIM1 and/or ORAI1 (zeige TMEM132A Antikörper) had been silenced by small interfering (si)RNA. We conclude that extracellular ATP activates SOCE in white adipocytes, an effect predominantly mediated by STIM1 and ORAI1 (zeige TMEM132A Antikörper).
Study shows that STIM1 and ORAI1 (zeige TMEM132A Antikörper) promotes membrane ruffling by showing that phospho-STIM1 localizes at the leading edge of cells, and that both phospho-STIM1 and ORAI1 (zeige TMEM132A Antikörper) co-localize with cortactin (zeige CTTN Antikörper).
Here, the authors show that hepatocytes from obese mice displayed significantly diminished store-operated Ca(2 (zeige CA2 Antikörper)+) entry as a result of impaired STIM1 translocation, which was associated with aberrant STIM1 O-GlycNAcylation.
Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2 (zeige CA2 Antikörper)+ entry (SOCE)-associated genes (STIM1, ORAI1 (zeige TMEM132A Antikörper) and TRPC1 (zeige TRPC1 Antikörper)).
Stim1 and Stim2 (zeige Stim2 Antikörper) deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization
STIM1 deletion protects the liver from ischemia/reperfusion injury in mice through inhibiting inflammation, oxidative stress and apoptosis.
These results highlight how STIM1-dependent Ca(2 (zeige CA2 Antikörper)+) microdomains have a major impact on intracellular Ca(2 (zeige CA2 Antikörper)+) homeostasis, cytoskeletal remodeling and cellular signaling, even when excitation-contraction coupling is present.
hearts of STIM1 haploinsufficient mice had a superficial resemblance to the WT phenotype under stress-free conditions; however, STIM1 haploinsufficient mice showed a maladaptive response to cardiac pressure overload
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b