Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN563045
Grosse, Braun, Varga-Szabo, Beyersdorf, Schneider, Zeitlmann, Hanke, Schropp, Mühlstedt, Zorn, Huber, Schmittwolf, Jagla, Yu, Kerkau, Schulze, Nehls, Nieswandt: An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. in The Journal of clinical investigation 2007
Show all 20 Pubmed References
Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1030706
Shen, Zhu, Zhang, Jiang, Wang, Zhang, Li, Huang, Ke, Ma, Du: Attenuated mesangial cell proliferation related to store-operated Ca(2+) entry in aged rat: the role of STIM 1 and Orai 1. in Age (Dordrecht, Netherlands) 2013
Show all 3 Pubmed References
Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1003211
Luik, Lewis: New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells. in Trends in molecular medicine 2007
Show all 4 Pubmed References
Cow (Bovine) Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN258795
Meuchel, Stewart, Smelter, Abcejo, Thompson, Zaidi, Martin, Prakash: Neurokinin-neurotrophin interactions in airway smooth muscle. in American journal of physiology. Lung cellular and molecular physiology 2011
Show all 2 Pubmed References
Human Monoclonal STIM1 Primary Antibody für ICC, IHC (p) - ABIN192394
Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume: Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. in American journal of physiology. Cell physiology 2010
Show all 9 Pubmed References
Human Monoclonal STIM1 Primary Antibody für ICC, IF - ABIN188961
Williams, Manji, Parker, Hancock, Van Stekelenburg, Eid, Senior, Kazenwadel, Shandala, Saint, Smith, Dziadek: Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. in The Biochemical journal 2001
Show all 3 Pubmed References
Human Monoclonal STIM1 Primary Antibody für IF, WB - ABIN396503
Verma, Hoffmann, Kumar, Huang, Roe, Nguyen-Wu, Hashimoto, Hoffmann: Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN2476609
Varga-Szabo, Braun, Kleinschnitz, Bender, Pleines, Pham, Renné, Stoll, Nieswandt: The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. in The Journal of experimental medicine 2008
Human Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN4356540
Wang, Choi, Richardson, Reid, Seymen, Yildirim, Tuna, Gençay, Simmer, Hu: STIM1 and SLC24A4 Are Critical for Enamel Maturation. in Journal of dental research 2015
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (zeige CA2 Antikörper)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (zeige CA2 Antikörper)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (zeige CA2 Antikörper)+) entry
STIM1 plays role in PAR1 (zeige F2R Antikörper)-mediated Ca2 (zeige CA2 Antikörper)+ influx and Ca2 (zeige CA2 Antikörper)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (zeige TRPC1 Antikörper)-dependent store-operated Ca2 (zeige CA2 Antikörper)+ entry plays an essential role in generating spatiotemporal Ca2 (zeige CA2 Antikörper)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (zeige ORAI1 Antikörper) are essential components of the signal transduction cascade that regulates sex pheromone production.
This activation was sensitive to Src kinase (zeige CSK Antikörper) inhibition, but not to CAMKII (zeige CAMK2G Antikörper) nor PKC (zeige PRRT2 Antikörper) inhibition, a result that sets STIM1 and SOCE as downstream targets of the axis Src (zeige SRC Antikörper)-Raf (zeige RAF1 Antikörper)-MEK (zeige MAP2K1 Antikörper)-ERK (zeige EPHB2 Antikörper), rather than upstream regulators.
STIM1 plays an important role in paraquat induced cell cycle arrest and cell death in acute lung injury.
we demonstrated that STIM1 could be involved in breast tumorigenesis and progression
Study provide clear evidence that STIM1 has a cholesterol-binding domain located inside the SOAR region and modulates Orai1 (zeige ORAI1 Antikörper) channels. A functional association of STIM1 and SOAR to cholesterol was shown, indicating a close proximity of SOAR to the inner layer of the plasma membrane. In contrast, the depletion of cholesterol induces the SOAR detachment from the plasma membrane and enhances its association to Orai1 (zeige ORAI1 Antikörper).
Our study clarifies the roles of major STIM1 functional domains in maintaining a quiescent configuration of STIM1 to prevent preactivation of SOCE.
The results of this study concluded that the phenotype associated with activating STIM1 mutations frequently includes extra-neuromuscular features such as hypocalcaemia, hypo-/asplenia and platelet dysfunction regardless of mutation domain.
Ca(2 (zeige CA2 Antikörper)+) unbinding in the STIM1 luminal domains initiates the conformational change allowing SOAR domain liberation and clustering, leading to Orai1 (zeige ORAI1 Antikörper) channel activation.
calmodulin (CaM) associates with the core region of STIM1 in a Ca2+-dependent manner. Consequently, calcium-bound CaM disrupts the STIM1-Orai1 complex and disassembles STIM1 oligomers, thereby inducing deactivation of the store-operated calcium entry.
STIM1 knockdown may inhibit the migration and invasion of A549 cells in vitro, and metastasis in vivo.
STIM1 is significantly upregulated in GC and that STIM1 overexpression is associated with a poor prognosis in GC patients with LNM and an advanced TNM (zeige ODZ1 Antikörper) stage. Therefore, STIM1 may be a useful prognostic marker for GC.
STIM1 and STIM2 (zeige Stim2 Antikörper) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (zeige ITPR1 Antikörper).
Silencing of beta 1 integrin gene regulates the gene expression of storeoperated Ca2 (zeige CA2 Antikörper)+ entry (SOCE)-associated genes (STIM1, ORAI1 (zeige TMEM132A Antikörper) and TRPC1 (zeige TRPC1 Antikörper)).
Stim1 and Stim2 (zeige Stim2 Antikörper) deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization
STIM1 deletion protects the liver from ischemia/reperfusion injury in mice through inhibiting inflammation, oxidative stress and apoptosis.
These results highlight how STIM1-dependent Ca(2 (zeige CA2 Antikörper)+) microdomains have a major impact on intracellular Ca(2 (zeige CA2 Antikörper)+) homeostasis, cytoskeletal remodeling and cellular signaling, even when excitation-contraction coupling is present.
hearts of STIM1 haploinsufficient mice had a superficial resemblance to the WT phenotype under stress-free conditions; however, STIM1 haploinsufficient mice showed a maladaptive response to cardiac pressure overload
Cultured hippocampal neurons expressing mutant PS1 (zeige PSEN1 Antikörper) had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1.
Loss-of-function mutations in the Ca(2 (zeige CA2 Antikörper)+) release-activated Ca(2 (zeige CA2 Antikörper)+) channel genes ORAI1 (zeige TMEM132A Antikörper) and STIM1 abolish store-operated Ca(2 (zeige CA2 Antikörper)+) entry (SOCE) and result in ectodermal dysplasia with amelogenesis imperfecta. SOCE is essential for proper enamel mineralization, in which Stim1 plays a critical role during the maturation process.
Reactive oxygen species (ROS (zeige ROS1 Antikörper)) production, degranulation, and phagocytosis are normal in the absence of STIM2 (zeige Stim2 Antikörper), suggesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses
Stromal interaction molecule 1 (STIM1), which regulates the refilling of ER Ca(2 (zeige CA2 Antikörper)+), has been investigated in several systems including the CNS. In addition to a previous study showing that STIM1 regulates dendritic ER Ca(2 (zeige CA2 Antikörper)+) refilling and mGluR1 (zeige GRM1 Antikörper)-mediated synaptic transmission, we provide compelling evidence describing a novel role of STIM1 in spike firing Purkinje neurons.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b