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anti-Human STIM1 Antikörper:
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Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN563045
Grosse, Braun, Varga-Szabo, Beyersdorf, Schneider, Zeitlmann, Hanke, Schropp, Mühlstedt, Zorn, Huber, Schmittwolf, Jagla, Yu, Kerkau, Schulze, Nehls, Nieswandt: An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. in The Journal of clinical investigation 2007
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Human Monoclonal STIM1 Primary Antibody für IF, WB - ABIN968271
Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. in Genomics 1998
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Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1003211
Luik, Lewis: New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells. in Trends in molecular medicine 2007
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Human Polyclonal STIM1 Primary Antibody für IHC, ELISA - ABIN1030706
Shen, Zhu, Zhang, Jiang, Wang, Zhang, Li, Huang, Ke, Ma, Du: Attenuated mesangial cell proliferation related to store-operated Ca(2+) entry in aged rat: the role of STIM 1 and Orai 1. in Age (Dordrecht, Netherlands) 2013
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Human Monoclonal STIM1 Primary Antibody für ICC, IF - ABIN188961
Williams, Manji, Parker, Hancock, Van Stekelenburg, Eid, Senior, Kazenwadel, Shandala, Saint, Smith, Dziadek: Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. in The Biochemical journal 2001
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Human Monoclonal STIM1 Primary Antibody für ICC, IHC (p) - ABIN192394
Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume: Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. in American journal of physiology. Cell physiology 2010
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Cow (Bovine) Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN258795
Meuchel, Stewart, Smelter, Abcejo, Thompson, Zaidi, Martin, Prakash: Neurokinin-neurotrophin interactions in airway smooth muscle. in American journal of physiology. Lung cellular and molecular physiology 2011
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Human Monoclonal STIM1 Primary Antibody für IF, WB - ABIN396503
Verma, Hoffmann, Kumar, Huang, Roe, Nguyen-Wu, Hashimoto, Hoffmann: Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2011
Human Monoclonal STIM1 Primary Antibody für IF, IHC (p) - ABIN2476609
Varga-Szabo, Braun, Kleinschnitz, Bender, Pleines, Pham, Renné, Stoll, Nieswandt: The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction. in The Journal of experimental medicine 2008
Human Polyclonal STIM1 Primary Antibody für ICC, IF - ABIN4356540
Wang, Choi, Richardson, Reid, Seymen, Yildirim, Tuna, Gençay, Simmer, Hu: STIM1 and SLC24A4 Are Critical for Enamel Maturation. in Journal of dental research 2015
Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (zeige CA2 Antikörper)+) signal triggered by the fertilizing sperm.
findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (zeige CA2 Antikörper)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (zeige CA2 Antikörper)+) entry
STIM1 plays role in PAR1 (zeige F2R Antikörper)-mediated Ca2 (zeige CA2 Antikörper)+ influx and Ca2 (zeige CA2 Antikörper)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1
STIM1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.
STIM1/TRPC1 (zeige TRPC1 Antikörper)-dependent store-operated Ca2 (zeige CA2 Antikörper)+ entry plays an essential role in generating spatiotemporal Ca2 (zeige CA2 Antikörper)+ signals that mediate guidance responses of nerve growth cones.
STIM1 and Orai1 (zeige ORAI1 Antikörper) are essential components of the signal transduction cascade that regulates sex pheromone production.
STIM1 is significantly upregulated in GC and that STIM1 overexpression is associated with a poor prognosis in GC patients with LNM and an advanced TNM (zeige ODZ1 Antikörper) stage. Therefore, STIM1 may be a useful prognostic marker for GC.
Here, we summarize the recent discoveries on the structure-function relationship of Orai1 (zeige ORAI1 Antikörper), as well as its interaction with the native channel opener STIM1 and chemical modulator 2-aminoethoxydiphenyl borate
the elevated expression of STIM1 might be involved in lung tumorigenesis.
TRPC1-STIM1 activation modulates transforming growth factor beta-induced epithelial-to-mesenchymal transition and cell migration.
Data show that the G98S and V107M mutations generate constitutively permeable ORAI1 (zeige ORAI1 Antikörper) channels, whereas T184M alters the channel permeability only in the presence of STIM1.
STIM1 contributes to the development of OTSCC.
Our findings demonstrate for the first time that STIM1 and store-operated calcium entry signaling are involved in the TGF-beta (zeige TGFB1 Antikörper)-induced suppression of cell proliferation
Cultured hippocampal neurons expressing mutant PS1 (zeige PSEN1 Antikörper) had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1.
These findings suggest that the surface location of SARAF (zeige TMEM66 Antikörper) is dependent on the expression of STIM1 in the plasma membrane.
sp(2) -Iminosugar alpha-glucosidase (zeige AGLU Antikörper) inhibitor 1 (zeige PPP1R1A Antikörper)-C-octyl-2-oxa-3-oxocastanospermine inhibits breast cancer cell migration via beta1-integrin, Stim1, and FAK (zeige PTK2 Antikörper) signaling pathways.
STIM1 and STIM2 (zeige Stim2 Antikörper) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (zeige ITPR1 Antikörper).
Stim1 and Stim2 (zeige Stim2 Antikörper) deficient B cells show an accelerated pace of affinity maturation but do not have dramatically impaired antibody production to T-independent antigen immunization
STIM1 deletion protects the liver from ischemia/reperfusion injury in mice through inhibiting inflammation, oxidative stress and apoptosis.
These results highlight how STIM1-dependent Ca(2 (zeige CA2 Antikörper)+) microdomains have a major impact on intracellular Ca(2 (zeige CA2 Antikörper)+) homeostasis, cytoskeletal remodeling and cellular signaling, even when excitation-contraction coupling is present.
hearts of STIM1 haploinsufficient mice had a superficial resemblance to the WT phenotype under stress-free conditions; however, STIM1 haploinsufficient mice showed a maladaptive response to cardiac pressure overload
Loss-of-function mutations in the Ca(2 (zeige CA2 Antikörper)+) release-activated Ca(2 (zeige CA2 Antikörper)+) channel genes ORAI1 (zeige TMEM132A Antikörper) and STIM1 abolish store-operated Ca(2 (zeige CA2 Antikörper)+) entry (SOCE) and result in ectodermal dysplasia with amelogenesis imperfecta. SOCE is essential for proper enamel mineralization, in which Stim1 plays a critical role during the maturation process.
Reactive oxygen species (ROS (zeige ROS1 Antikörper)) production, degranulation, and phagocytosis are normal in the absence of STIM2 (zeige Stim2 Antikörper), suggesting STIM1 is the dominant calcium sensor required for classical short-term neutrophil responses
Stromal interaction molecule 1 (STIM1), which regulates the refilling of ER Ca(2 (zeige CA2 Antikörper)+), has been investigated in several systems including the CNS. In addition to a previous study showing that STIM1 regulates dendritic ER Ca(2 (zeige CA2 Antikörper)+) refilling and mGluR1 (zeige GRM1 Antikörper)-mediated synaptic transmission, we provide compelling evidence describing a novel role of STIM1 in spike firing Purkinje neurons.
data indicate that STIM1 overexpression in neurons in the brain perturbs metabotropic glutamate (zeige GRIN1 Antikörper) receptor signaling, leading to impairments in long-term depression and alterations in animal behavior
Ca(2 (zeige CA2 Antikörper)+) entry serves critical cellular functions in virtually every cell type, and appropriate regulation of Ca(2 (zeige CA2 Antikörper)+) in neurons is essential for proper function.
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.
stromal interaction molecule 1
, stromal interaction molecule 1b