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anti-Human PKC theta Antikörper:
anti-Mouse (Murine) PKC theta Antikörper:
anti-Rat (Rattus) PKC theta Antikörper:
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Human Monoclonal PKC theta Primary Antibody für IHC (f), IF - ABIN967738
Dienz, Hehner, Droge, Schmitz: Synergistic activation of NF-kappa B by functional cooperation between vav and PKCtheta in T lymphocytes. in The Journal of biological chemistry 2000
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Human Monoclonal PKC theta Primary Antibody für IHC (f), IF - ABIN967739
Nishizuka: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. in Nature 1988
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Human Polyclonal PKC theta Primary Antibody für IHC - ABIN966842
Xu, Chaudhary, Olland, Wolfrom, Czerwinski, Malakian, Lin, Stahl, Joseph-McCarthy, Benander, Fitz, Greco, Somers, Mosyak: Catalytic domain crystal structure of protein kinase C-theta (PKCtheta). in The Journal of biological chemistry 2004
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Human Monoclonal PKC theta Primary Antibody für IHC (f), WB - ABIN968924
Soderling: Protein kinases. Regulation by autoinhibitory domains. in The Journal of biological chemistry 1990
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Human PKC theta Primary Antibody für IHC - ABIN966839
Bonny, Nicod, Waeber: IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. in The Journal of biological chemistry 1998
Human Monoclonal PKC theta Primary Antibody für ICS - ABIN1176929
Parker, Murray-Rust: PKC at a glance. in Journal of cell science 2003
Human Polyclonal PKC theta Primary Antibody für IF (p), IHC (p) - ABIN711746
van Rees, Lago, Cox, Tomasik, Rustogi, Weigelt, Ozcan, Cooper, Drexhage, Leweke, Bahn: Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients. in Brain, behavior, and immunity 2017
The results indicate that PKC (zeige FYN Antikörper) could be the final target and an integrator molecule of different signaling pathways triggered by angiotensin II (Ang II), which could explain the sustained activation of Na(+)-ATPase (zeige DNAH8 Antikörper) by Ang II (zeige AGT Antikörper).
Phorbol 12-myristate 13-acetate activation of ERK (zeige MAPK1 Antikörper) and JNK (zeige MAPK8 Antikörper) signaling is relevant in the regulation of gene expression during follicular development, ovulation, and luteinization.
PKC-theta; is strongly and exclusively expressed in GISTs and interacts with intracellular mutant KIT to promote its stabilization by increased retention in the Golgi complex. PKC-theta; plays critical roles in the sustained activation of MT-KITs. Overexpression of PKC-theta; significantly correlates with several clinicopathological parameters
PCR and transcriptome analysis suggest that the genes CD3D (zeige CD3D Antikörper) and PKRCQ together can be used as a model for differentiating between B-cell and T-cell acute lymphoblastic leukemia.
PKC-theta; is a critical factor for type 2 innate lymphoid cells activation that contributes to TH2 cell differentiation, which is associated with IRF4 (zeige IRF4 Antikörper) and NFAT1 (zeige NFAT1 Antikörper) expression in allergic lung inflammation.
Enhanced PRKCQ/PKCtheta; expression can promote growth-factor-independent growth, anoikis resistance, and migration. PRKCQ critically regulates growth and survival of a subset of TNBC.
Data suggest that, in T-lymphocytes, nitric oxide generated by eNOS (zeige NOS3 Antikörper) S-nitrosylates Cys374 on ACTB (zeige ACTB Antikörper) and thus regulates activation/recruitment of PRKCQ at immune synapse; S-nitrosylation of beta-actin (zeige ACTB Antikörper) impairs actin binding to PFN1 (zeige PFN1 Antikörper) and regulates protein transport in lamellipodia. (eNOS (zeige NOS3 Antikörper) = nitric oxide synthase (zeige NOS Antikörper) 3; ACTB (zeige ACTB Antikörper) = beta-actin (zeige ACTB Antikörper); PRKCQ = protein kinase C-theta; PFN1 (zeige PFN1 Antikörper) = profilin-1 (zeige PFN1 Antikörper))
PKCtheta;-induced phosphorylations control the ability of Fra-1 (zeige FOSL1 Antikörper) to stimulate gene expression and breast cancer cell migration.
Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition.
Data show that tonantzitlolone (TZL) was able to induce protein kinase c theta (PKCtheta;)-dependent heat shock transcription factor 1 (HSF1 (zeige HSF1 Antikörper))phosphorylation.
The PRKCQ polymorphism is not associated with Behcet's Disease.
Sumoylation of PKC-theta; was essential for T cell activation. Desumoylation did not affect the catalytic activity of PKC-theta; but inhibited the association of CD28 (zeige CD28 Antikörper) with PKC-theta; and filamin A (zeige FLNA Antikörper) and impaired the assembly of a mature immunological synapse.
PKCtheta; selectively inactivates the negative regulator of F-actin generation, Coronin 1A (zeige CORO1A Antikörper), at the center of the T cell interface with the antigen presenting cell (APC (zeige APC Antikörper)). This allows for effective generation of the large actin-based lamellum required for recruitment of the Notch (zeige NOTCH1 Antikörper)-processing membrane metalloproteinase ADAM10 (zeige ADAM10 Antikörper).
Results suggest that while PKCtheta; is involved in Treg cell differentiation in vivo, it is dispensable for Treg-mediated suppression.
Data show that pharmacological inhibition of Protein Kinase C theta (PKCtheta;) in Duchenne Muscular Dystrophy (DMD (zeige DMD Antikörper)) can be considered an attractive strategy to modulate immune response and prevent the progression of the disease.
Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A (zeige CORO1A Antikörper) on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB (zeige NFKB1 Antikörper) transactivation.
Knockdown of PKCtheta suppresses phosphorylation of IKK (zeige CHUK Antikörper) and JNK (zeige MAPK8 Antikörper) and consequently attenuates the HOCl-impaired insulin (zeige INS Antikörper) signaling pathway.
Data indicate that Protein kinase C theta; (PKCtheta;) is critical for stabilizing Th17 cell phenotype.
Data suggest that protein kinase (zeige CDK7 Antikörper) Ctheta (PKCtheta;) inhibition alone is insufficient for complete efficacy in rodent arthritis model.
Inhibition of PKC-theta preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
protein kinase C theta type
, PKC theta