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Interactions between HPK1 and its adaptor proteins related to immunity has been discussed (Review).
HPK1 protein expression, which is expressed at significantly higher levels in NATs compared with paired IDC (zeige LMNA Proteine)-NOS (zeige NOS1 Proteine) tissues, is significantly negatively associated with ER positivity and is positively associated with OS duration, suggesting that HPK1 may exhibit anticancer activities.
CUL7/Fbxw8 (zeige FBXW8 Proteine) ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 (zeige FBXW8 Proteine) ubiquitin ligase in the MAPK (zeige MAPK1 Proteine) pathway, which plays a critical role in cell proliferation and differentiation.
HPK1 is critically involved in LFA-1 (zeige ITGAL Proteine)-mediated polymorphonuclear neutrophils trafficking during acute inflammation.
results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia (zeige BCL11A Proteine) cells, but the cleaved HPK1 fragment inhibits differentiation
Pdcd4 (zeige PDCD4 Proteine) knockdown up-regulates MAP kinase (zeige MAPK1 Proteine) kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun (zeige JUN Proteine).
QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased.
HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters.
The purpose of the study was to investigate the potential contribution of HPK1, MEKK1 (zeige MAP3K1 Proteine), TAK1 (zeige MAP3K7 Proteine), p-MKK4 (zeige MAP2K4 Proteine) to the development of extramammary Paget disease
The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription.
Introduction of three 4-R-hydroxyproline residues stabilizes the SH3m-cortactin (zeige CTTN Proteine) binding of HPK1 peptide.
a novel negative feedback regulation of BCR (zeige BCR Proteine) signaling by HPK1-mediated phosphorylation, ubiquitination, and subsequent degradation of the activated BLNK (zeige BLNK Proteine)
HPK1 associates with SKAP1 (zeige SKAP1 Proteine) to negatively regulate Rap1 (zeige TERF2IP Proteine)-mediated B-lymphocyte (zeige AKAP17A Proteine) adhesion.
HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion.
Hpk1 supports apoptosis of T lymphocytes by inhibiting the antiapoptotic action of NF-kappaB (zeige NFKB1 Proteine) and inducing the proapoptotic activity of JNK (zeige MAPK8 Proteine).
Mona/Gads (zeige GRAP2 Proteine) SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix
suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death
HPK1-C as a suppressor of antiapoptotic Bcl-2 (zeige BCL2 Proteine) proteins and provide a molecular basis for our understanding of CD95L (zeige FASL Proteine)-independent activation-induced cell death of lymphocytes.
Our data reveal a novel role for HPK1 as a negative regulator of dendritic cell functions
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
mitogen-activated protein kinase kinase kinase kinase 1
, MAPK/ERK kinase kinase kinase 1
, MEK kinase kinase 1
, MEKKK 1
, hematopoietic progenitor kinase 1
, mitogen activated protein kinase kinase kinase kinase 1