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HLA-DP polymorphisms (rs3077 and rs9277535) were associated with Systemic lupus erythematosus susceptibility in a Chinese population
High frequency expression of DPB1*0401 and *0601 are significantly associated with susceptibility to rheumatoid arthritis, it may be a risk factor for occurrence of rheumatoid arthritis. Low frequency expression of DPB1*0101, *0402 and *0501 may be negatively associated with rheumatoid arthritis, it may be a protective factor for occurrence of rheumatoid arthritis.
The rs3117242 of HLA-DPB1 could be considered a genetic risk factor for granulomatosis with polyangiitis in Chinese Han people.
HLA-DPB1*05:01 gene was associated with the geographical region of PV and the BTNL2 (zeige BTNL2 Proteine) gene was significantly associated with family history and age of onset of PV. In conclusion, the HLA-DPB1*05:01 and BTNL2 (zeige BTNL2 Proteine) genes might be responsible for the complicacy of clinical features.
In this single-center study, HLA-DPB1 matching influenced outcomes of patients undergoing ASCT for hematologic malignancy.
HLA-DPB1*15:01 allele was more frequent in the spontaneous seroconverted control group compared to Chronic hepatitis B Turkish patients.
Genotyping and expression analysis in HLA class II gene revealed that two single nucleotide polymorphisms of HLA-DPB1 (rs2071025 and rs3116996) were significantly correlated to RNA expression and progression of hepatitis C virus-related liver diseases.
The results showed that rs9277535 HLA-DPB1 allele frequency is associated with chronic hepatitis B infection in the Turkish patients.
report contributes to emerging data showing clinical significance of the HLA-DP region genetic markers beyond structural matching of DPB1 alleles.
The HLA-DP rs9277535 variant genotypes were directly associated with hepatitis B virus persistence compared to healthy controls.
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
major histocompatibility complex, class II, DP beta 1
, B-L beta minor
, BLB major
, Bl-Beta II protein
, MHC class II B-L beta chain
, MHC class II antigen beta chain
, MHC class II beta 1 domain
, MHC class II beta chain 1
, MHC class II beta chain 2
, major histocompatibility complex class II B
, HLA DP14-beta chain
, HLA class II histocompatibility antigen, DP beta 1 chain
, HLA class II histocompatibility antigen, DP(W4) beta chain
, HLA-DP histocompatibility type, beta-1 subunit
, MHC HLA DPB1
, MHC class II HLA-DP-beta-1
, MHC class II HLA-DRB1
, MHC class II antigen DP beta 1 chain
, MHC class II antigen DPB1
, MHC class II antigen DPbeta1
, beta1 domain MHC class II HLA DPB
, class II HLA beta chain
, major histocompatibility complex class II antigen beta chain