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These data provide a mechanistic insight into the paratope-epitope relationship between an alloantibody and its target HLA-A*11.01 molecule in a biological context where other immune receptors are concomitantly engaged.
From this preliminary study, it is suspected that there may be a role of HLA-A*11, HLA-B*35 and HLA-DRB1*10 in conferring susceptibility to influenza A(H1N1)pdm09 infection in the study population.
we determined the survival outcomes for combinations of TRB gene segment usage and HLA class I alleles, with the most important result being that the combination of HLA-A*01:01 and TRB-J1 segment usage reflected a strikingly high survival rate
Eastern Han Chinese patients with the HLA-A*3201 allele may be more susceptible to OXC-induced cutaneous adverse reactions in Eastern Han Chinese population.
HLA-A*24, the SLC30A8 T allele and high BMI are associated with poor graft outcome in type 1 diabetics undergoing pancreatic islet transplantation.
These data suggest that HLA-A*02:07 might be a genetic risk factor for developing clarithromycin-related cutaneous adverse drug reactions in Han Chinese and serve as a useful biomarker for personalized medicine to prevent these adverse reactions
Allelic and haplotype diversity of HLA-A, HLA-B and HLA-DRB1 gene at high resolution in the Nanning Han population.
Results indicted that HLA-A*02 and HLA-DRB1 (*0407, *15 and *1501) polymorphisms might increase the risk of aplastic anemia (AA), while HLA-DRB1 (*0301, *04, *0406, *0802, *1301, *1302 and *14) were protective against AA.
The HLA-A*31:01 allele is associated with carbamazepine-DRESS syndrome in Tunisians.
HLA-A2 status was not identified as prognostic for benefit in a large advanced NSCLC population treated with platinum-based chemotherapy.
HLA-A*31:01 and HLA-B*15:02 alleles confer susceptibility to carbamazepine-induced severe cutaneous adverse reactions.
Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups.
The association of the HLA-A*24:02, HLA-B*39:01 and HLA-B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/HLA-DQ haplotypes in Finns.
in the Iranian population, HLA-A*68 confers susceptibility to Graves' disease
this study shows a significant protective function for HLA-A*30 gene against chronic renal failure development in Yemeni patients
The authors concluded that in the Chinese population, HLA-A*02:01 and DRB1*11:01 might be associated with the host capacity to clear hepatitis C virus independent of IL28B, which suggests that the innate and adaptive immune responses both play an important role in the control of hepatitis C virus.
These results suggest a detrimental role of HLA-A-Bw4 and HLA-C2 groups, which are associated with the development of chronic hepatitis B, and a protective role of KIR2DL3.
data showed that the presence of the HLA class II allele DQB1*03:02 was a correlate of immune protection against HIV infection, while the presence of the HLA class I allele A*02:01 was associated with being infected with HIV.
The difference in MS risk between the extremes was considerable; smokers carrying HLA-DRB1*15 and lacking HLA-A*02 had a 13-fold increased risk compared with never smokers without these genetic risk factors (OR 12.7, 95% CI 10.8-14.9). The risk of MS associated with HLA genotypes is strongly influenced by smoking status and vice versa.
in this exploratory analysis of tuberculosis and HLA allele frequencies in Dene and Cree cohorts HLA-A*03 and HLA-DQB1*05:03 were significantly associated with tuberculosis in Manitoba, Canada
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A