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data showed that the presence of the HLA class II allele DQB1*03:02 was a correlate of immune protection against HIV infection, while the presence of the HLA class I (zeige MICA Proteine) allele A*02:01 was associated with being infected with HIV.
The difference in MS risk between the extremes was considerable; smokers carrying HLA-DRB1*15 and lacking HLA-A*02 had a 13-fold increased risk compared with never smokers without these genetic risk factors (OR 12.7, 95% CI 10.8-14.9). The risk of MS associated with HLA genotypes is strongly influenced by smoking status and vice versa.
in this exploratory analysis of tuberculosis and HLA allele frequencies in Dene and Cree cohorts HLA-A*03 and HLA-DQB1 (zeige HLA-DQB1 Proteine)*05:03 were significantly associated with tuberculosis in Manitoba, Canada
A total of 39 HLA-A, 66 HLA-B and 47 HLA-DRB1 (zeige HLA-DRB1 Proteine) alleles were identified.
results demonstrate that HIV-1 Nef's inferior ability to downregulate MHC-B compared to that of MHC-A is conserved across primate lentiviruses and suggest that this property influences antiviral cellular immune responses.
Data (from studies using TCR-F50/GIL (zeige AQP3 Proteine)/HLA-A2) suggest there are multiple solutions to recognizing identical peptide-MHC (zeige HLAE Proteine) ligand with sufficient affinity to elicit broad anti- influenza virus response protective against viral escape. (TCR-F50 = GIL (zeige AQP3 Proteine)-specific T-cell receptor, alpha-beta; HLA-A2 major histocompatibility complex class I A; GIL (zeige AQP3 Proteine) = immunodominant influenza A virus epitope from M1) [M1, matrix protein 1]
In the present study, the HLA-A*31:01 allele was identified as a risk allele of lamotrigine-induced severe cutaneous adverse reactions in Koreans
Three new HLA class I alleles, HLA-A*02:620, HLA-B*27:150 and HLA-B*07:05:01:02, were described in the Spanish Caucasoid population
Data suggest that KH1 (zeige KCNF1 Proteine) and HK2 (zeige HK2 Proteine) domains of MEX3C (zeige MEX3C Proteine) bind with high affinity to MRE10, a 10-mer (zeige MERTK Proteine) RNA (5prime-CAGAGUUUAG-3prime) containing an eight-nucleotide MEX3C (zeige MEX3C Proteine) recognition element motif (AGAGUUUA); 3prime-untranslated region of HLA-A2 mRNA contains such a high affinity binding site for KH domains of MEX3C (zeige MEX3C Proteine). (MEX3C (zeige MEX3C Proteine) = mex-3 (zeige MEX3D Proteine) RNA binding family member C; HLA-A2 = HLA class I (zeige MICA Proteine) histocompatibility antigen, A-2 alpha chain (zeige FCGRT Proteine))
this study shows that alpha3-deletion isoform of HLA-A11 plays role in the immune escape of HIV-1
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
HLA class I histocompatibility antigen, A-1 alpha chain
, MHC class I antigen HLA-A heavy chain
, antigen presenting molecule
, leukocyte antigen class I-A