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The proto-oncogene (zeige RAB1A Proteine) GAB2 (11q14.1) was significantly amplified in non-smokers patients and GAB2 protein was relatively up-regulated in non-smoker than smoker tissues. GAB2 may represent a potential biomarker for lung SCC (zeige CYP11A1 Proteine) in non-smokers
There was no significant association between single nucleotide polymorphisms (SNPS) of GAB2 rs2373115 (G > T) and PICALM (zeige PICALM Proteine) rs541458 (C > T) and Alzheimer's disease (AD). The allele T of rs3851179 in PICALM (zeige PICALM Proteine) was associated with a 13 % increase in the risk of AD. Seven SNPs on SORL1 (zeige SORL1 Proteine) were significantly associated with AD.
Results show that up-regulation of Gab2 expression was found to be positively correlated with VEGF (zeige VEGFA Proteine) in colorectal cancer (CRC (zeige CALR Proteine)) tissues, and suggest that Gab2 promotes intestinal tumor growth and angiogenesis through upregulation of VEGF (zeige VEGFA Proteine) expression mediated by the MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine)/c-Myc (zeige MYC Proteine) pathway.
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 and their complexes with Shp2 (zeige PTPN11 Proteine). VEGFR2 (zeige KDR Proteine) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2. As Gab2 binds VEGFR2 (zeige KDR Proteine) complexes more transiently than Gab1, VEGFR2 (zeige KDR Proteine) complexes can recycle and continue to participate in other signaling pathways.
The authors showed that GAB2 is cleaved at G238 during Coxsackievirus type B3 infection by viral proteinase 2A, generating two cleaved fragments of GAB2-N1-237 and GAB2-C238-676.
Studied BAK1 (zeige BAK1 Proteine), SPRY4 (zeige SPRY4 Proteine) and GAB2 SNPs in pediatric germ cell tumors(GCT (zeige QPCT Proteine)); found a variant in SPRY4 (zeige SPRY4 Proteine) was associated with reduced risk of GCT (zeige QPCT Proteine); a variant in BAK1 (zeige BAK1 Proteine) was positively associated with GCT (zeige QPCT Proteine) with a strong estimated effect for testis tumors; and a SNP in GAB2 was associated with increased risk for GCT (zeige QPCT Proteine).
overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating expression of CXCL1 (zeige CXCL1 Proteine), CXCL2 (zeige CXCL2 Proteine) and CXCL8 (zeige IL8 Proteine) that is IKKbeta (zeige IKBKB Proteine)-dependent.
GAB2 is a key intermediary between YAP (zeige YAP1 Proteine)/TAZ (zeige TAZ Proteine) and the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) pathway.
The findings of this study suggested that GAB2 rs2373115 may contribute to Alzheimer's disease susceptibility only in European population but not in East Asian population.
ERK1 and ERK2 interact with Gab2 via a novel docking motif, which is required for subsequent Gab2 phosphorylation in response to ERK1/2 activation.
we demonstrated for the first time that Gab2 deficiency has a profound effect on the course of disease in an in vivo chronic myeloid leukemia (zeige BCL11A Proteine) model
High Gab2 expression is associated with myeloproliferative neoplasm.
Gab2 may be a disease-associated protein that is induced by pathogenic factors to amplify and coordinate multifactor-induced signals to govern disease development in the liver.
Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 are recruited to Il4r (zeige IL4R Proteine), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 = growth factor receptor bound protein 2-associated protein 2; Il4r (zeige IL4R Proteine) = interleukin-4 receptor (zeige IL4R Proteine))
Given that GAB2 is dispensable for normal hematopoiesis, GAB2 and its effectors PI3K and SHP2 represent promising targets for therapy in Ph(+)hematologic neoplasms
Down-regulation of Gab2 has a protective function during M. tuberculosis infection, revealing a potential negative regulatory role for Gab2 in immunity to TB.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
These results define a novel role for Gab2 in mediating mucin (zeige SLC13A2 Proteine) gene expression and GCH (zeige GCH1 Proteine); these findings have important implications for the pathogenesis and therapy of airway inflammatory diseases.
Our data provide genetic and biochemical evidence that CSF-1R, through Gab2, utilizes different effectors at different stages of MNP development to promote their expansion
Data indicate that fetal liver cells isolated from homozygous STAT5 (zeige STAT5A Proteine) mutant mice lacking Gab2 showed significant reduction in HSC (zeige FUT1 Proteine) number and survival.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
GRB2-associated binding protein 2
, GRB2-associated-binding protein 2
, Grb2-associated binder 2
, growth factor receptor bound protein 2-associated protein 2
, GRB2-associated binder 2
, Grb2 associated binder 2
, PH domain-containing adaptor molecule p97