anti-Maus FYB Antikörper für Immunocytochemistry

Recommended FYB Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
FYN-Binding Protein (FYB) Antikörper
  • fyb
  • ADAP
  • PRO0823
  • SLAP-130
  • B630013F22Rik
  • FYB-120/130
  • Slap130
  • p120/130
  • p120/p130
  • RGD1563421
  • FYN-binding protein
  • FYN binding protein 1
  • FYN binding protein
  • fyb
  • FYB1
  • Fyb
  • Fyb1
Epitop
C-Term
21
9
8
8
4
3
2
1
1
1
1
Reaktivität
Human, Maus
95
29
25
6
5
4
3
3
2
2
Wirt
Kaninchen
61
22
11
2
Klonalität
Polyklonal
Konjugat
Dieser FYB Antikörper ist unkonjugiert
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
71
44
13
10
10
5
4
4
4
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN1001738
$ 523.71
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN6261835 ELISA ICC IF IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1030221 ICC ELISA WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN1887297 ICC ELISA WB Rabbit C-Term Anmelden zum Anzeigen Polyclonal 0

General

Antigen FYN-Binding Protein (FYB) Antikörper
Epitop C-Term
(21), (9), (8), (8), (4), (3), (2), (1), (1), (1), (1)
Reaktivität Human, Maus
(95), (29), (25), (6), (5), (4), (3), (3), (2), (2)
Wirt Kaninchen
(61), (22), (11), (2)
Klonalität
Polyklonal
Konjugat Dieser FYB Antikörper ist unkonjugiert
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
(71), (44), (13), (10), (10), (5), (4), (4), (4), (2), (1), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-FYB Antikörper

Target Details FYB Anwendungsinformationen Handhabung Referenzen für anti-FYB Antikörper (ABIN1001738) Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN1003727.
Reinigung Affinity chromatography purified via peptide column.
Immunogen ADAP antibody was raised in rabbits against a 20 amino acid peptide from near the carboxy terminus of human ADAP.
Isotyp IgG
Plasmids, Primers & others

Target Details FYB

Produktdetails anti-FYB Antikörper Anwendungsinformationen Handhabung Referenzen für anti-FYB Antikörper (ABIN1001738) Bilder zurück nach oben
Antigen
Andere Bezeichnung ADAP (FYB Antibody Abstract)
Hintergrund The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.
Pathways T-Zell Rezeptor Signalweg, Protein targeting to Nucleus

Anwendungsinformationen

Produktdetails anti-FYB Antikörper Target Details FYB Handhabung Referenzen für anti-FYB Antikörper (ABIN1001738) Bilder zurück nach oben
Applikations-hinweise ADAP antibody can be used for detection of ADAP by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-FYB Antikörper Target Details FYB Anwendungsinformationen Referenzen für anti-FYB Antikörper (ABIN1001738) Bilder zurück nach oben
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Lagerung 4 °C
Haltbarkeit 12 months

Referenzen für anti-FYB Antikörper (ABIN1001738)

Produktdetails anti-FYB Antikörper Target Details FYB Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Medeiros, Burbach, Mueller, Srivastava, Moon, Highfill, Peterson, Shimizu: "Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1." in: Science (New York, N.Y.), Vol. 316, Issue 5825, pp. 754-8, 2007

Mueller, Thomas, Burbach, Peterson, Shimizu: "Adhesion and degranulation-promoting adapter protein (ADAP) positively regulates T cell sensitivity to antigen and T cell survival." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 6, pp. 3559-69, 2007

Rawlings, Sommer, Moreno-García: "The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes." in: Nature reviews. Immunology, Vol. 6, Issue 11, pp. 799-812, 2006

Griffiths, Krawczyk, Kong, Raab, Hyduk, Bouchard, Chan, Kozieradzki, Oliveira-Dos-Santos, Wakeham, Ohashi, Cybulsky, Rudd, Penninger: "Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap." in: Science (New York, N.Y.), Vol. 293, Issue 5538, pp. 2260-3, 2001