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anti-Human Filamin A Antikörper:
anti-Rat (Rattus) Filamin A Antikörper:
anti-Mouse (Murine) Filamin A Antikörper:
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Human Monoclonal Filamin A Primary Antibody für IHC (p), PLA - ABIN560922
Valente, Logan, Mougou-Zerelli, Lee, Silhavy, Brancati, Iannicelli, Travaglini, Romani, Illi, Adams, Szymanska, Mazzotta, Lee, Tolentino, Swistun, Salpietro, Fede, Gabriel, Russ, Cibulskis, Sougnez et al.: Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. ... in Nature genetics 2010
Show all 8 Pubmed References
Human Monoclonal Filamin A Primary Antibody für WB - ABIN1882243
Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. in The Journal of cell biology 1990
Show all 6 Pubmed References
Human Polyclonal Filamin A Primary Antibody für ICC, IF - ABIN188803
Thoms, Loveridge, Simpson, Clipson, Reinhardt, Dunlop, Stark: Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination. in Cancer research 2010
Show all 2 Pubmed References
Knockdown of filamin A or vimentin (zeige VIM Antikörper) in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.
FLN90, an isoform of the Drosophila ortholog Filamin/cheerio that lacks the actin (zeige ACTB Antikörper)-binding domain, is here shown to govern the growth of postsynaptic membrane folds and the composition of glutamate (zeige GRIN2A Antikörper) receptor clusters at the larval neuromuscular junction.
Here we show using Drosophila indirect flight mus (zeige KPTN Antikörper)cle that t (zeige FLNC Antikörper)he filamin ortholog Cheerio in conjunction with the giant elastic protein titin plays a crucial role in keeping thin filaments stably anchored at the Z-disc. We identify the filamin domains required for interaction with the (zeige TTN Antikörper) titin ortholog Sallimus, and we demonstrate a genetic interaction of filamin with titin and actin.
study identifies Cher as a new target of JNK (zeige MAPK8 Antikörper) signaling that links cytoskeleton dynamics to tumor progression.
Data indicate that during embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells.
Filamin is required for ovarian follicle cell motility during oogenesis.
Data show that AR-deficient and highly metastatic prostate cancer cell lines express higher levels of filamin A compared to normal prostate epithelial cells and AR-positive and less metastatic prostate cancer. Also, the results identified that Cao2+ via CaR-mediated signaling induces filamin A cleavage and promotes the migration in AR-deficient and highly metastatic prostate cancer cells.
FLNA is downregulated in parathyroid tumors and parallels the CASR (zeige CASR Antikörper) expression levels. Loss of FLNA reduces CASR (zeige CASR Antikörper) mRNA and protein expression levels and the CASR (zeige CASR Antikörper)-induced ERK (zeige EPHB2 Antikörper) phosphorylation. FLNA is involved in receptor expression, membrane localization and ERK (zeige EPHB2 Antikörper) signaling activation of both 990R and 990G CASR (zeige CASR Antikörper) variants.
Lowering the FLNA level elevated RalA (zeige rala Antikörper) activity and resulted in selective interference with the normal intracellular trafficking and signaling of the D2R (zeige DRD2 Antikörper) and D3R, through GRK2 (zeige ADRBK1 Antikörper) and beta-arrestins, respectively. FLNA is a multi-functional protein that acts as a platform on which D2R (zeige DRD2 Antikörper) and D3R can interact with various proteins causing selective regulation of these receptors occurs in combination with GRK2 (zeige ADRBK1 Antikörper) and beta-arrestins.
FLNA upregulation correlates with Snail (zeige SNAI1 Antikörper)-induced epithelial to mesenchymal transition in colorectal carcinoma.
Our findings expand the male-specific phenotype of FLNA mutations that now includes classical-like EDS with lethal cardiac valvular dystrophy, and offer further insights for the genotype-phenotype correlations within this spectrum.
Study identifies ANXA4 (zeige ANXA4 Antikörper) and FLNA as up-regulated in buccal squamous cell carcinoma arising from oral submucous fibrosis.
These results provide new insights into the regulation of SK2 (zeige KCNN2 Antikörper) channel trafficking by the cytoskeletal proteins FLNA and alpha-actinin2, involving distinct recycling pathways
Respiratory failure secondary to progressive obstructive lung disease during infancy may be the presenting phenotype of FLNA-associated periventricular nodular heterotopia.
The actin regulator FLNA interacts with the endoplasmic reticulum stress kinase PERK and this interaction is required for the efficient formation of ER-plasma membrane contact sites.
CCR2B (zeige CCR2 Antikörper) and beta2AR (zeige ADRB2 Antikörper) signals to FLNa to stimulate its endocytosis and recycling to the plasma membrane.
filamin reduces ENaC (zeige SCNN1A Antikörper) channel function through direct interaction on the cell surface
FlnA and Fmn2 (zeige FMN2 Antikörper) are likely essential to cell proliferation, differentiation and cell death in a variety of tissues and organs, further reiterating the importance of vesicle trafficking in regulation of development
both LRP1 (zeige LRP1 Antikörper) and LDLR (zeige LDLR Antikörper) expression and agLDL uptake are regulated by P2Y2R (zeige P2RY2 Antikörper) in vascular smooth muscle cells, and agLDL uptake due to P2Y2R (zeige P2RY2 Antikörper) activation is dependent upon cytoskeletal reorganization mediated by P2Y2R (zeige P2RY2 Antikörper) binding to FLN-A
FlnA is a negative regulator of beta2 integrin-dependent cell adhesion and reactive oxygen species production but is required for neutrophil extracellular traps production in primary murine neutrophils
Here the authors report that intermediate progenitor's neuron production is enhanced by abrogating filamin function, leading to the generation of periventricular neurons independent of normal neocortical neurogenesis and neuronal migration.
These results show that FLNA plays crucial roles in asymmetric division during meiotic maturation by regulating ROCK-cofilin-mediated actin reorganization.
FlnA binding to PACSIN2 (zeige PACSIN2 Antikörper) F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.
FlnA is a critical upstream element of the signaling cascade underlying the myogenic tone.
Bones lacking filamin A are protected from estrogen-mediated post-menopausal osteoporosis
findings suggest a model in which filamin A local translation following axon injury controls localized HDAC5 (zeige HDAC5 Antikörper) activity to promote axon regeneration.
Deletion of filamin A in endothelial cells aggravated myocardial infarction-induced left ventricle dysfunction and cardiac failure as a result of defective endothelial response
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
, filamin A, alpha (actin binding protein 280)
, filamin B, like
, filamin A, alpha
, filamin B
, filamin isoform B
, shi kong
, actin binding protein 280
, endothelial actin-binding protein
, non-muscle filamin
, Endothelial actin-binding protein 280)
, filamin, alpha
, 450 kDa protein
, GENA 379
, actin-binding protein 280
, dilated pupils 2
, filamin A