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Human Polyclonal DRB1 Primary Antibody für ICC, IF - ABIN4306272
Collins, Riascos, Kovalik, An, Krupa, Krupa, Hood, Conrads, Renton, Traynor, Bowser: The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. in Acta neuropathologica 2012
a new member of RRM-type neural RNA-binding protein
the interaction between the HLA-DRB1 (zeige HLA-DRB1 Antikörper)*1501 allele and MBP (zeige MBL2 Antikörper) gene may be considered as a predisposing factor in the development and pathogenesis of multiple sclerosis in the case of gene-gene interaction
The authors concluded that in the Chinese population, HLA-A*02:01 and DRB1 (zeige RBM45 Antikörper)*11:01 might be associated with the host capacity to clear hepatitis C virus independent of IL28B (zeige IL28B Antikörper), which suggests that the innate and adaptive immune responses both play an important role in the control of hepatitis C virus.
genetic association studies in cohort in Denmark: Data suggest that standard immunosuppression treatment failure in patients with autoimmune hepatitis is not associated with thiopurine S-methyltransferase (zeige TPMT Antikörper) genetic variants or HLA-DRB1 (zeige HLA-DRB1 Antikörper)*03 genotype in the population studied.
Review/Meta-analysis: Report association of HLA-DRB1 (zeige HLA-DRB1 Antikörper) alleles with rheumatoid arthritis among Arabs.
HLA association analysis of patients infected with modern MTB (zeige NCAPG2 Antikörper) strains showed significant association for HLA-DRB1 (zeige HLA-DRB1 Antikörper)*09:01 (odds ratio [OR] = 1.82; P-value = 9.88 x 10(-4) ) and HLA-DQB1 (zeige HLA-DQB1 Antikörper)*03:03 alleles (OR = 1.76; P-value = 1.31 x 10(-3) ) with susceptibility to TB. Haplotype analysis confirmed that these alleles were in strong linkage disequilibrium and did not exert an interactive effect.
Using genome-wide association meta-analysis authors discover two regions associated with longevity (HLA-DQA1 (zeige HLA-DQA2 Antikörper)/DRB1 (zeige RBM45 Antikörper) and LPA (zeige APOA Antikörper)).
The risk of actinic prurigo associated with HLA-DRB1 (zeige HLA-DRB1 Antikörper)*03:01 in Chinese patients living in Singapore is reported.
These results have shown a strong association of HLA-DRB1 (zeige HLA-DRB1 Antikörper)*03 with MG, especially for EOMG also in our population. HLA-DRB1 (zeige HLA-DRB1 Antikörper)*01 was associated to LOMG suggesting that is a susceptibility factor for this subgroup of the disease.
The difference in MS risk between the extremes was considerable; smokers carrying HLA-DRB1*15 and lacking HLA-A*02 had a 13-fold increased risk compared with never smokers without these genetic risk factors (OR 12.7, 95% CI 10.8-14.9). The risk of MS associated with HLA genotypes is strongly influenced by smoking status and vice versa.
HLA-DRB1/DQB1 gene variants appeared to modulate the alteration of the left posterior cingulate volume, hence modulating the susceptibility of Alzheimer's disease.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
, HLA class II histocompatibility antigen, DR-1 beta chain
, MHC class II HLA-DR beta 1 chain
, MHC class II HLA-DR-beta cell surface glycoprotein
, MHC class II HLA-DRw10-beta
, MHC class II antigen
, human leucocyte antigen DRB1
, lymphocyte antigen DRB1
, RNA-binding motif protein 45
, RNA-binding protein 45
, developmentally regulated RNA-binding protein 1
, developmentally-regulated RNA-binding protein 1