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CDC42 loss suppresses acute myeloid leukemia (zeige BCL11A ELISA Kits) cell polarity and division asymmetry.
CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
LRCH1 (zeige LRCH1 ELISA Kits) as a novel effector to restrain PKCalpha (zeige PKCa ELISA Kits)-DOCK8 (zeige DOCK8 ELISA Kits)-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
analysis of phenotypes of Cdc42 and Myo10 (zeige MYO10 ELISA Kits) deletion that show multiple roles of filopodial dynamics
Finally, we demonstrate that Cdc42 is involved in neuroligin-dependent presynaptic differentiation of proprioceptive sensory neurons in vitro These data suggest that Cdc42 in presynaptic sensory neurons is essential for proper synapse formation in the development of monosynaptic sensory-motor circuits.
found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain
These results indicate that HuR (zeige ELAVL1 ELISA Kits) promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
Lrrk1 deficiency in osteoclasts resulted in reduced phosphorylation and activation of RAC1/Cdc42
Akt3 (zeige AKT3 ELISA Kits) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (zeige WNK1 ELISA Kits)/SGK1 (zeige SGK1 ELISA Kits)/Cdc42 pathway.
Cdc42 is essential for cardiomyocyte proliferation, sarcomere organization and cell-cell adhesion during heart development.
N-WASP positively regulates demarcation membrane system development and proplatelet formation, and the Src family kinases in association with CDC42 regulate proplatelet formation through N-WASP
miR (zeige MLXIP ELISA Kits)-424-->cdc42-->prdm14 (zeige PRDM14 ELISA Kits) axis as a key molecular signalling cascade that might influence breast cancer progression in diabetic patients through hyperactivation of cancer stem cells.
viral protein US28 was acting through CDC42, rearranging actin microfilaments, causing association of actin with lipid rafts, and leading to a dramatic change in the abundance and/or structure of lipid rafts.
Study describes a novel quantitative approach to determine Cdc42 activity at specific subcellular locations and reveals new regulatory principles and functions of this small GTPase (zeige RACGAP1 ELISA Kits).
Study Cdc42 regulates Cdc42EP3 (zeige CDC42EP3 ELISA Kits) function in cancer-associated fibroblasts.
The structural basis for Cdc42-induced dimerization of IQGAP1 (zeige IQGAP1 ELISA Kits) and IQGAP2 (zeige IQGAP2 ELISA Kits) has been uncovered.
Polarity signaling via CDC42/atypical protein kinase C (zeige PRKCZ ELISA Kits) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.
Circular RNA ccHIAT1 functions as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion via miR (zeige MLXIP ELISA Kits)-195-5p/29a-3p/29c-3p/CDC42 signaling pathway.
CDC42 plays an important role in promoting pancreatic cancer development and might serve as a prognostic indicator of pancreatic cancer.
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
cell division cycle 42
, Rho family small GTP binding protein cdc42
, G25K GTP-binding protein
, cell division control protein 42 homolog
, cell division cycle 42 homolog
, GTP binding protein, 25kDa
, GTP-binding protein, 25kD
, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
, growth-regulating protein
, small GTP binding protein CDC42