anti-Human CD80 Antikörper für Enzyme Immunoassay

Recommended CD80 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD80 Antikörper
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • CD80 molecule
  • Cd80 molecule
  • CD80 antigen
  • CD80
  • Cd80
Reaktivität
Human
455
286
49
11
11
6
3
3
2
2
1
Wirt
Maus
398
126
97
94
42
16
Klonalität
Monoklonal
Konjugat
Dieser CD80 Antikörper ist unkonjugiert
71
70
53
40
19
17
16
15
10
7
7
6
6
6
6
6
6
6
6
5
5
5
5
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
509
220
171
153
115
100
80
42
40
26
22
22
12
8
8
6
5
5
5
5
2
2
2
2
1
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN1106582
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
4 ABIN615921 EIA WB Goat Internal Region Anmelden zum Anzeigen Polyclonal 1

General

Antigen CD80 Antikörper
Reaktivität Human
(455), (286), (49), (11), (11), (6), (3), (3), (2), (2), (1)
Wirt Maus
(398), (126), (97), (94), (42), (16)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD80 Antikörper ist unkonjugiert
(71), (70), (53), (40), (19), (17), (16), (15), (10), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(509), (220), (171), (153), (115), (100), (80), (42), (40), (26), (22), (22), (12), (8), (8), (6), (5), (5), (5), (5), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD80 Antikörper

Target Details CD80 Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN1106582) Bilder
Spezifität Recognizes CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen).
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Ascites
Klon 2A2
Isotyp IgG1
Plasmids, Primers & others

Target Details CD80

Produktdetails anti-CD80 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN1106582) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD80 (CD80 Antibody Abstract)
Hintergrund The protein CD80 (Cluster of Differentiation 80) is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells. Mouse research by scientists at Emory University showed that estrogen-related bone loss is linked to recently discovered pathways involving various proteins, such as CD80 and other functions. In a nutshell, reactive oxygen stimulates dendritic cells, which activate other immune cells to up-regulate production of CD80, the molecule co-responsible for T cell activation. "When this pathway is activated, it leads to increased T cell TNF production and ultimately to bone loss." In turn, T cells produce a protein, Tumor Necrosis Factor, which increases the formation of osteoclasts in rodents and humans. Osteoclasts cause minerals to be released from the bone, so that calcium is taken into the bloodstream to be used for other functions of the body. Osteoclast differentiation is inhibited by osteoprotegerin, Estrogen stimulates osteoprotegerin production.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
Molekulargewicht 55 kDa
Gen-ID 941
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process

Anwendungsinformationen

Produktdetails anti-CD80 Antikörper Target Details CD80 Handhabung Referenzen für anti-CD80 Antikörper (ABIN1106582) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Referenzen für anti-CD80 Antikörper (ABIN1106582) Bilder zurück nach oben
Format Liquid

Referenzen für anti-CD80 Antikörper (ABIN1106582)

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Wang, Liu, Wu, Zhu, Wang, Xu: "Evaluation of CD86/CD28 and CD40/CD154 pathways in regulating monocyte-derived CD80 expression during their interaction with allogeneic endothelium." in: Transplantation proceedings, Vol. 40, Issue 8, pp. 2729-33, 2008

Stephan, Ponomarev, Brentjens, Chang, Dobrenkov, Heller, Sadelain: "T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection." in: Nature medicine, Vol. 13, Issue 12, pp. 1440-9, 2007

Bilder

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN1106582) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody
Immunofluorescence (IF) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-CD80 (CD80) antibody (ABIN1106582) anti-CD80 (CD80) antibody (Image 3)