anti-Hund CD80 Antikörper für Blocking Reagent

Recommended CD80 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
CD80 Antikörper
  • B7
  • B7-1
  • B7.1
  • BB1
  • CD28LG
  • CD28LG1
  • LAB7
  • B71
  • Cd28l
  • Ly-53
  • Ly53
  • MIC17
  • TSA1
  • CD80 molecule
  • Cd80 molecule
  • CD80 antigen
  • CD80
  • Cd80
Reaktivität
Hund, Maus
498
293
49
11
10
6
3
3
3
2
1
1
Wirt
Armenischer Hamster
442
126
100
94
45
17
Klonalität
Monoklonal
Konjugat
Dieser CD80 Antikörper ist unkonjugiert
76
75
56
44
21
19
19
17
10
9
9
7
7
7
7
7
7
6
6
6
6
6
5
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Blocking Reagent (BR), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
556
223
173
157
118
101
82
43
40
26
23
22
13
8
7
6
6
5
5
5
4
2
2
2
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN2689407
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1176972 BR IHC (fro) FACS IP Armenian Hamster IgG2, kappa Anmelden zum Anzeigen 16-10A1 6
1 ABIN1967873 BR FACS Func IHC IHC (fro) IP Neut Hamster IgG2 Anmelden zum Anzeigen 16-10A1 0

General

Antigen CD80 Antikörper
Reaktivität Hund, Maus
(498), (293), (49), (11), (10), (6), (3), (3), (3), (2), (1), (1)
Wirt Armenischer Hamster
(442), (126), (100), (94), (45), (17)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser CD80 Antikörper ist unkonjugiert
(76), (75), (56), (44), (21), (19), (19), (17), (10), (9), (9), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Blocking Reagent (BR), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
(556), (223), (173), (157), (118), (101), (82), (43), (40), (26), (23), (22), (13), (8), (7), (6), (6), (5), (5), (5), (4), (2), (2), (2), (2), (1), (1), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-CD80 Antikörper

Target Details CD80 Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN2689407) Bilder
Marke BD Pharmingen™
Produktmerkmale The 16-10A1 antibody reacts with CD80 (B7-1). This member of the Ig superfamily, along with CD86 (B7-2), participates in T-cell co-stimulation via interactions with CD28 and CD152 (CTLA-4). CD80 has been reported to be constitutively expressed on dendritic cells, monocytes, and peritoneal macrophages, and it is inducible on B cells by various means, including activation by LPS, IL-4, and the cross-linking of surface Ig. Expression of CD80 has been reported to be greatly enhanced on splenic B cells following activation by LPS, with peak expression occurring between 48 and 72 hours. It has been reported that the activation of purified B cells with LPS can induce CD80 expression in as few as 18 hours. The 16-10A1 antibody has been reported to block binding of CTLA-4 Ig to CD80 and to block T-cell activation by Con A-elicited peritoneal exudate cells and CD80-transfected cell lines. However, 16-10A1 antibody alone is not able to block T-cell activation by antigen-presenting cells. CD86 (B7-2) is an alternate ligand for CD28 and CD152 (CTLA-4). Preliminary reports indicate that the 16-10A1 mAb may block the binding of rat anti-CD80 mAb clone 1G10 (Cat. No. 553368). In addition, it has been reported that the 16-10A1 antibody may cross-react with an activation antigen expressed on IFN-γ-activated alveolar macrophages of the dog. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

BD Pharmingen™ Purified Hamster Anti-Mouse CD80 - Purified - Clone 16-10A1 - Isotype Armenian Hamster IgG2, κ - Reactivity Ms, Dog - 0.5 mg
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Mouse CD80 (B7) Transfected Cell Line
Klon 16
Isotyp IgG2, kappa
Plasmids, Primers & others

Target Details CD80

Produktdetails anti-CD80 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-CD80 Antikörper (ABIN2689407) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD80 (CD80 Antibody Abstract)
Hintergrund Synonyms: B7-1
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process

Anwendungsinformationen

Produktdetails anti-CD80 Antikörper Target Details CD80 Handhabung Referenzen für anti-CD80 Antikörper (ABIN2689407) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Referenzen für anti-CD80 Antikörper (ABIN2689407) Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C.

Referenzen für anti-CD80 Antikörper (ABIN2689407)

Produktdetails anti-CD80 Antikörper Target Details CD80 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Herold, Vezys, Koons, Lenschow, Thompson, Bluestone: "CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 2, pp. 984-91, 1997

Bluestone: "New perspectives of CD28-B7-mediated T cell costimulation." in: Immunity, Vol. 2, Issue 6, pp. 555-9, 1995

Boussiotis, Gribben, Freeman, Nadler: "Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance." in: Current opinion in immunology, Vol. 6, Issue 5, pp. 797-807, 1995

Harlan, Hengartner, Huang, Kang, Abe, Moreadith, Pircher, Gray, Ohashi, Freeman: "Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 3137-41, 1994

Hathcock, Laszlo, Pucillo, Linsley, Hodes: "Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function." in: The Journal of experimental medicine, Vol. 180, Issue 2, pp. 631-40, 1994

Razi-Wolf, Freeman, Galvin, Benacerraf, Nadler, Reiser: "Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 9, pp. 4210-4, 1992