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These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4 (zeige CD4 Proteine)(+) T lymphocytes.
The aim of this case-control study is to investigate whether GABRG2 (zeige GABRG2 Proteine) polymorphisms contribute to susceptibility for Febrile seizure and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea.
The rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28 were, respectively, found to be correlated with incremental susceptibility to recurrent spontaneous abortion under the allelic model.
Study utilized targeted next-gen sequencing to identify a novel splicing variation (NM_198903.2:c.1249-1G > T) in the GABRG2 (zeige GABRG2 Proteine) gene of a febrile seizure (FS) patient. The potential association of ten selected genetic polymorphisms in IL1RN (zeige IL1RN Proteine) (86-bp VNTR), IL10 (zeige IL10 Proteine) (rs1900872), PTGS2 (zeige PTGS2 Proteine) (8 SNPs, rs689465, rs689466, rs20417, rs13306038, rs201931599, rs689470, rs4648306 and rs4648308) with FS was also examined.
Coexpression of CD200R-CD28 enhances function in WT1 (zeige CD200R1 Proteine)-specific T-cell receptor - transduced (zeige CD8A Proteine) human primary T cells.
the upregulation of others syncytial molecules, including LAG3 (zeige LAG3 Proteine), CTLA4 (zeige CTLA4 Proteine), CD28 and CD3 (zeige CD3 Proteine), assisting the formation of syncytia with APC (zeige APC Proteine) cells.
our data provide the first evidence of a strict link between the absence of CD28 and the expression of perforin (zeige PRF1 Proteine), which is likewise enhanced by the expression of NKG2D (zeige KLRK1 Proteine), within selected CD4 (zeige CD4 Proteine)(+) T cells from cervical cancer patients.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck (zeige LCK Proteine) complex of protein kinase (zeige CDK7 Proteine) Ctheta; (PKCtheta (zeige PRKCQ Proteine);), which serves as a key effector kinase in the CD28 signaling pathway.
This study identified a missense de novo mutation in the GABAA (zeige GABRg1 Proteine) receptor gamma2 subunit, P302L, in a patient with Dravet syndrome. The mutation has a novel pathogenic mechanism to cause defects in the conductance and gating of GABAA (zeige GABRg1 Proteine) receptors, which results in hyperexcitability and contributes to the pathogenesis of the genetic epilepsy Dravet syndrome.
The mutant CD28 isoforms could accelerate tumor cell growth.
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2 (zeige CA2 Proteine)+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR (zeige TFRC Proteine) cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR (zeige TFRC Proteine) cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R (zeige CD200R1 Proteine)-CD28-transduced leukemia-specific CD8 (zeige CD8A Proteine) T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 (zeige IL2 Proteine) administration to sustain in vivo activity.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP (zeige TXNIP Proteine) and miR33 expression, and this leads to a transient induction of Cpt1a (zeige CPT1A Proteine) and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF (zeige TNF Proteine)
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 (zeige CTLA4 Proteine) functions as the main brake but is also dependent on TCR signals and interactions with CD80 (zeige CD80 Proteine)/CD86 (zeige CD86 Proteine).
data suggest that mPEG PV1 (zeige PLVAP Proteine)-Fab (zeige FANCB Proteine)' acts mainly on IFN-gamma (zeige IFNG Proteine)-producing CD4 (zeige CD4 Proteine)+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
BAFF (zeige TNFSF13B Proteine) upregulates CD28/B7 and CD40 (zeige CD40 Proteine)/CD154 (zeige CD40LG Proteine) expression, and promotes the interactions between T and B cells in a BAFF-R (zeige TNFRSF13C Proteine)-dependent manner
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
, T-cell-specific surface glycoprotein CD28
, GABA(A) receptor subunit gamma-2
, GABA(A) receptor, gamma 2
, gamma-aminobutyric acid receptor subunit gamma-2
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog