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Congenic knockout mice and mice overexpressing Sept5 in the hippocampus or amygdala were indistinguishable from control mice in novelty and olfactory responses, anxiety or motor activity
Report SEPT4 (zeige SEPT4 Proteine)/5/7 expression in mouse cochlea and roles in auditory function.
The result of this study suggested that Septin 5 is a core molecular substrate that differentiates distinct release modalities at the central synapse.
Here, we showed existence of two Sept5 isoforms in the mouse and studied their tissue and developmental expressions that would be helpful for exploring isoform specific function.
a role for CDCrel-1 in platelet secretion and aggregation.
Transgenic mice expressing dominant negative parkin (zeige PARK2 Proteine) mutant accumulated moderate levels of Septin 5 in substantia nigra-dopaminerergic neurons. A threshold level of Septin 5 is required for dopaminergic cell loss.
the interaction of Sept5 with syntaxin-1 (zeige STX1A Proteine) is regulated by the phosphorylation of Sept5_v1 at Ser17 by Cdk5 (zeige CDK5 Proteine)-p35 (zeige CDK5R1 Proteine)
SEPT3 (zeige SEPT3 Proteine) and SEPT5 are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.
Sept5 deficiency exerts pleiotropic effects on a select set of affective behaviors and cognitive processes.
CDCrel-1 overexpression exerts dopamine-dependent neurotoxicity and may contribute to the development of autosomal-recessive juvenile parkinsonism
We studied the assembly of three human septins, SEPT4 (zeige SEPT4 Proteine), SEPT5 and SEPT8 (zeige SEPT8 Proteine), with each other (heterotypic) and with themselves (homotypic) using a yeast two-hybrid system.
the high expression levels of PNUTL1 in human pancreatic endocrine cells that suggests a similar role of this protein in islet cells to that demonstrated in neuronal tissues, and warrants further functional studies of this protein.
Our finding suggests a role for members of the septin (zeige SEPT6 Proteine) family in the development of proliferative retinal membranes.
HSP70 (zeige HSP70 Proteine) and constitutively active HSF1 (zeige HSF1 Proteine) mediate protection against CDCrel-1-mediated toxicity
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB\; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.
, cell division control related protein 1
, cell division control-related protein 1
, peanut-like 1 homolog
, peanut-like protein 1
, peanut-like 1
, platelet glycoprotein Ib beta chain