anti-Serotonin Receptor 3A (HTR3A) Antikörper

Mouse (Murine) Serotonin Receptor 3A (HTR3A) Interaktionspartner

1. analysis of the structure from the full-length 5-HT3AR channel in the apo (zeige C9orf3 Antikörper)-state determined by single-particle cryo-electron microscopy

2. Transmission of sour taste information involves communication between taste cells and 5-HT3A-expressing afferent nerve fibers.

3. the recently available murine 5-HT3 receptor by identifying sites of strong interaction with particular functional groups at both the orthogonal (serotonin) site and a proposed allosteric binding site situated at the interface between the transmembrane region and the extracellular domain, was characterized.

4. We conclude that cholera toxin inhibits colonic migrating motor complexes via release of mucosal 5-HT (zeige DDC Antikörper), which activates an inhibitory pathway involving 5-HT3 receptors

5. It was concluded that epithelial 5-HT3 receptor may function as a mediator of gut (zeige GUSB Antikörper) microbiota-driven change in intestinal secretion.

6. 5HT3A receptor deletion in neuroblasts impaired speed and directionality of migration and abolished calcium spikes.

7. Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity

8. 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3

9. found the protein levels of AMPA (zeige GRIA3 Antikörper) receptor subunits (GluR1 (zeige GRIA1 Antikörper) and GluR2 (zeige GRIA2 Antikörper)) are upregulated in the amygdala and the 5-HT3 receptor is downregulated in hypothalamic regions of Socially Isolated mice.

10. The data of this study demonstrated that the 5-HT3 receptor is the critical target of 5-HT (zeige DDC Antikörper) action in exercise-induced hippocampal neurogenesis and antidepressant effects, but not in learning enhancement.

Human Serotonin Receptor 3A (HTR3A) Interaktionspartner

1. Methylation status of the HTR3A gene in mothers is linked to maternal violence-related psychopathology, trauma-induced brain activation patterns, and child attachment disturbance during a sensitive period in the development of self-regulation.

2. This study did not found HTR3A play a major role in predicting Antipsychotic-Induced Weight Gain.

3. Methylation pattern changes in the 5-HTR3A gene were associated with suicidal behavior in borderline personality disorder, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD).

4. findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients.

5. Study provides structural data showing the orientation of palonosetron in a 5-HT3 receptor binding site mimic, combined with functional data in the 5-HT3 receptor, provide an explanation for the high affinity and long-lived actions of this compound. These are likely due to specific interactions formed with binding site residues, and its location as a tight and effective wedge in the binding pocket.

6. Studies have demonstrated that 5-HT3 receptors modulate the activity of vascular and non-vascular smooth muscles.

7. The HTR3A rs1062613 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype.

8. Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity

9. Analysis of our small Chinese sample revealed a significant association of HTR3A with bipolar disorder, but yielded no evidence of an association between HTR3B (zeige HTR3B Antikörper) and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A.

10. Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line