Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Although extravillous trophoblasts express three S1P receptor isoforms, S1P predominantly signals through S1PR2/Galpha12/13 to activate Rho, and thereby acts as potent inhibitor of extravillous trophoblast migration.
Butyrate and bioactive proteolytic form of Wnt-5a (zeige WNT5A Proteine) regulate colonic epithelial proliferation and spatial development
SNPs within 0.1 Mb of the S1PR2 gene as well as within the gene itself were interrogated as a candidate gene association for hearing loss. For 1 kHz thresholds, the adjacent SNP rs74930654 showed the most significant association. For 4 kHz, the most significant association was with rs201930568. These findings suggest that variants affecting the S1PR2 gene do contribute to auditory thresholds in the UK population.
Data show that sphingosine kinase 1 (SPHK1 (zeige SPHK1 Proteine)) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1 (zeige SGPL1 Proteine)) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P (zeige MBTPS1 Proteine))-induced migration of OSCC cells.
High S1PR2 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis.
CONCLUSION: MiR (zeige MLXIP Proteine)-126 down-regulated S1PR2 and then prevented the activation of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling pathway, which ultimately could damage intestinal mucosal barrier function.
Data suggest that activation of SR-BI (zeige SCARB1 Proteine) by APOAI down-regulates sphingosine 1-phosphate/S1PR2-mediated inflammation in vascular endothelial cells by activating the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) signaling pathway; oxidized-LDL does the opposite. (APOA1 (zeige APOA1 Proteine) = apolipoprotein A-I (zeige APOA1 Proteine); SR-BI/SCARB1 (zeige SCARB1 Proteine) = scavenger receptor class B type I; S1PR2 = sphingosine 1-phosphate receptor 2; PI3K (zeige PIK3CA Proteine) = phosphatidylinositol 3-kinase; Akt (zeige AKT1 Proteine) = proto-oncogene c-akt (zeige AKT1 Proteine))
S1PR2 mediates Rho activation in normal cells neighboring RasV12-transformed cells.
Sphingosine 1-phosphate-induced IL-8 (zeige IL8 Proteine) gene expression is mainly regulated via S1PR(1 (zeige S1PR1 Proteine)), and its secretion is regulated through S1PR(2) receptor subtype.
S1PR2 is repressed by FOXP1 (zeige FOXP1 Proteine) in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 (zeige FOXP1 Proteine) levels; S1PR2 expression is further inversely correlated with FOXP1 (zeige FOXP1 Proteine) expression in 3 DLBCL patient cohorts.
A new spontaneous mouse mutation (stonedeaf, stdf ) leading to recessive, early-onset progressive hearing loss was detected and exome sequencing revealed a Thr289Arg substitution in S1pr2. Endocochlear potential (EP) was normal at 2 weeks old but was reduced by 4 and 8 weeks old in mutants, and the stria vascularis, which generates the EP, showed degenerative changes.
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (zeige RUNX2 Proteine)) expression through S1PR2/RhoA (zeige RHOA Proteine)/ROCK/Smad1 (zeige SMAD1 Proteine)/5/8 signaling.
Results provide evidence that S1PR2 plays an essential role in modulating proinflammatory cytokine production and osteoclastogenesis.
activation of S1P2 with a selective receptor agonist increases cell viability and reduces cisplatin-mediated cell death by reducing ROS (zeige ROS1 Proteine). Cumulatively, these results suggest that S1P2 may serve as a therapeutic target for attenuating cisplatin-mediated ototoxicity.
S1P2 receptor is a key signaling molecule in the S1Pdependent inhibition of adipogenic differentiation.
S1PR2, as a critical receptor in macrophages, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis.
These results suggest that S1PR2 and CXCR5 (zeige CXCR5 Proteine) cooperatively regulate localization of Tfh cells in GCs (zeige UGCG Proteine) to support GC responses
The sphingolipid receptor S1PR2 is a receptor for Nogo-a (zeige RTN4 Proteine) repressing synaptic plasticity.
S1PR2 expression was increased in disease-susceptible regions of the CNS of female SJL EAE mice compared with their male counterparts.
IL-6 (zeige IL6 Proteine) increased the number of osteoclast precursor cells in tibial bone marrow via up-regulating S1PR2, thus playing a crucial role in systemic bone loss induced by inflammation.
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation
sphingosine-1-phosphate receptor 2
, sphingosine 1-phosphate receptor 2-like
, S1P receptor 2
, S1P receptor EDG5
, S1P receptor Edg-5
, endothelial differentiation G-protein coupled receptor 5
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
, sphingosine 1-phosphate receptor 2
, sphingosine 1-phosphate receptor Edg-5
, G-protein coupled receptor 13
, lysophospholipid receptor B2
, sphingosine-1-phosphate receptor S1P(2)
, G-protein coupled receptor H218