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A two-hit loss involving VHL (zeige VHL Proteine) predicted for clear-cell renal cell carcinoma (zeige MOK Proteine)(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53 (zeige TP53 Proteine), or RELN predicted for Sarcomatoid clear-cell renal cell carcinoma (zeige MOK Proteine) and worse prognosis.
we determined that Reelin protein and mRNA levels increased in CJD (zeige PRNP Proteine) human samples and in mouse models of human prion (zeige PRNP Proteine) disease in contrast to murine models of prion (zeige PRNP Proteine) infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevent their use as an efficient diagnostic biomarker.
In primary-culture fetal astrocytes, streptozotocin down-regulated the expression of Reelin 410 and 180 kDa , while alpha-boswellic acid upregulated it. Interruption in astroglial Reelin/Akt (zeige AKT1 Proteine)/Tau signaling pathways may have a role in Alzheimer disease.
In frontal cortex extracts, an increase in Reelin mRNA, and in soluble and insoluble (guanidine-extractable) Reelin protein, was associated with late Braak stages of Alzheimer's disease (AD), while expression of its receptor, ApoER2 (zeige LRP8 Proteine), did not change.
This study detected significant reductions in the mRNAs associated with RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder.
There results suggest that reelin played essential roles in the development of lymphoma and might be a potential drug target in lymphoma
This review addresses recent advances in the field of nonneuronal reelin signaling.
methylation status of the promoter proximal cytosine-phospho-guanine dinucleotides determines the expression of RELN in myeloma cells.
Meta-analyses of 12 RELN gene single nucleotide polymorphisms (SNPs) and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders) with subgroup analyses based on ethnicity. Findings suggest a role of RELN SNPs in psychiatric diseases.
Significant association between rs17458357 , rs2572683,rs12555895 within the RELN gene and accelerated decline in Cognition performance in Chinese elderly male Gout population.
These results indicate that Reelin is an important regulator of GPIb-mediated platelet activation and may represent a new therapeutic target for the prevention and treatment of cardio- and cerebrovascular diseases
ITSN1 (zeige ITSN1 Proteine) is a component of Reelin signaling that acts predominantly by facilitating the VLDLR (zeige VLDLR Proteine)-Dab1 (zeige DAB1 Proteine) axis to direct neuronal migration in the cortex and hippocampus and to augment synaptic plasticity.
These results suggest that CTR (zeige CALCR Proteine)-dependent Reelin functions are required for some specific normal brain functions and that DeltaC-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder.
Reelin directly promotes N-cadherin (zeige CDH2 Proteine)-dependent neuronal adhesion, causing neuronal aggregation.
The results of this study reveal that the Reelin/Dab1 (zeige DAB1 Proteine) pathway contributes to the fine tuning of the density of perisynaptic astroglial ensheathment of synapses established on newborn Granule Cells, with overactivation of the pathway resulting in reduced ensheathment and Reelin-downregulation leading to increased ensheathment.
Model selection was performed on different model structures and a comprehensive mechanistic model of the early Reelin signaling cascade is provided in this work
found that Reelin protein with intact C-terminal region binds preferentially toPurkinje cells
This study demonstrated that both the loss of reelin protein expression, caused by genetic mutation, and prenatal pesticide exposure can alter the shape and connectivity of neurons in several brain regions.
CHD7 (zeige CHD3 Proteine) is necessary for maintaining an open, accessible chromatin state at the Reln locus. Taken together, this study shows that Reln gene expression is regulated by chromatin remodeling, identifies CHD7 (zeige CHD3 Proteine) as a previously unrecognized upstream regulator of Reln, and provides direct in vivo evidence that a mammalian CHD (zeige CHRD Proteine) protein can control brain development
Developmental gene expression pattern of reelin, dab1 (zeige DAB1 Proteine), vldlr (zeige VLDLR Proteine), and apoer2 (zeige LRP8 Proteine) in the central nervous system of zebrafish was compared, and their remarkable expression was detected in the developing laminar structures and also non-laminated structures.
A peak in Reelin mRNA and protein expression is present in the pig embryonic brain during the period of major neurogenesis and neuronal migration.
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
extracellular matrix serine protease
, reelin, extracellular