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Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release.
Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells.
Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein.
Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified
alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity
Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis.
Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles
a possible role in glomerulopathies
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism.
Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association.
In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population.
Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP).
Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis
The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity.
Rab3A might function as a marker of cortical granules and participates in cortical granule exocytosis in mouse eggs.
Rab3a deficiency promotes constitutive secretion and underlies selective impairment of Ca(2)-dependent release of alpha-MSH
Rab3a deletion restores excitatory/inhibitory imbalance in synapsin II(-) hippocampal slices.
betaARs couple to a cAMP/Epac/PLC/Munc13-1/Rab3a/RIM1a-dependent pathway to enhance glutamate release at cerebrocortical nerve terminals.
key role of Rab3a proteins control the balance between secretory vesicle biogenesis and degradation, and suggest that the ablation of this protein probably changes the nature of the reservoir of secretory vesicles available for regulated exocytosis.
Data show diminished actin plasticity in the cell processes of Rab3A knockout (KO) podocytes.
these findings suggest a crucial role of Rab3A in delivering vesicles to Ca2+ -dependent release sites at ribbon synapses.
We conclude that Rab3A is involved in a novel presynaptic mechanism to homeostatically regulate the amount of transmitter in a quantum.
roles in maintaining the total store of synaptic vesicles and cooperate in promoting the latest steps of neuronal secretion.
We suggest that Rab3A may regulate SNAP-29-mediated membrane fusion during myelination
Data show that Rab3A is highly and specifically expressed in brain regions.
The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm.
role in regulatory mechanism of neurotransmitter release
Phenotypic assessment of earlybird mice and a null allele of Rab3a revealed anomalies in circadian period and sleep homeostasis, providing evidence that Rab3a-mediated synaptic transmission is involved in these behaviors
Rab3A protein has a role in exocytosis
Rab3A reduces the potency of adenosine as an endogenous mediator of neuromuscular depression
Rab3A plays an important in vivo role facilitating the efficiency of insulin exocytosis, most likely at the level of replenishing the ready releasable pool of beta-granules
Rab3A in the GTP bound conformation prevents activity-dependent facilitation of exocytosis in bovine adrenal chromaffin cells
Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
RAS-associated protein RAB3A
, ras-related protein Rab-3A
, Ras-related small GTP binding protein 3A
, SMG P25A
, ras-related protein Rab-3C
, RAB3A, member RAS oncogene family