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anti-Human PTPRD Antikörper:
anti-Mouse (Murine) PTPRD Antikörper:
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our study suggested that PTPRD loci are candidate susceptibility regions that have some marker SNPs for GDM in Han Chinese
We investigated the modification of air pollution and diabetes association by a genetic risk score covering 63 T2D genes. Five single variants near GRB14 (zeige GRB14 Antikörper), UBE2E2 (zeige UBE2E2 Antikörper), PTPRD, VPS26A (zeige VPS26A Antikörper) and KCNQ1 (zeige KCNQ1 Antikörper) showed nominally significant interactions with PM10 (P<0.05). Our results suggest that genetic risk for T2D may modify susceptibility to air pollution through alterations in insulin (zeige INS Antikörper) sensitivity
Mutation in PTPRD gene is associated with nodal marginal zone lymphoma.
Low PTPRD expression is associated with Head and Neck Squamous Cell Carcinoma.
The data provide evidence of the high incidence of PTPRD inactivation in laryngeal squamous cell carcinoma, suggesting that deletions and loss-of-function mutations are responsible for PTPRD loss only in a fraction of cases, whereas DNA methylation (zeige HELLS Antikörper) is the dominating mechanism of PTPRD inactivation.
PTPRD polymorphisms might modulate antipsychotic-induced weight gain.
PTPRD was identified as a novel locus potentially associated with blood pressure response to atenolol and resistant hypertension in multiple ethnic groups.
PTPRD mutation, but not methylation or copy number loss, may serve as a predictive biomarker of sensitivity to STAT3 (zeige STAT3 Antikörper) inhibitors in HNSCC.
Study shows for the first time that DNMT1 (zeige DNMT1 Antikörper) caused PTPRD DNA hypermethylation and induced insulin (zeige INS Antikörper) signaling silencing in T2D patients.
PTPRD is homozygously deleted and epigenetically downregulated in hepatocellular carcinomas (HCCs (zeige HCCS Antikörper)).
Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR (zeige PTPRF Antikörper) and RPTPsigma (zeige PTPRS Antikörper) and Modulation of the Rho/ROCK Pathway.
Ptprd is a tumor suppressor that can promote tumorigenesis in concert with Cdkn2a (zeige CDKN2A Antikörper) loss.
We reveal that PTPRD is a bona fide tumor suppressor, pinpoint PTPRD loss as a cause of aberrant STAT3 (zeige STAT3 Antikörper) activation in gliomas, and establish PTPRD loss, in the setting of CDKN2A/p16(INK4A (zeige CDKN2A Antikörper)) deletion, as a driver of glioma progression.
RPTP-sigma (zeige PTPRS Antikörper) and RPTP-delta complement each other functionally during mammalian development, and reveal an essential contribution of RPTP-sigma (zeige PTPRS Antikörper) and RPTP-delta to appropriate motoneuron axon targeting during mammalian axonogenesis.
Receptor protein tyrosine phosphatase (zeige PTPRT Antikörper)-delta cooperates with hedgehog (zeige SHH Antikörper)-responsive gene MIM (zeige MTSS1 Antikörper) to induce cytoskeletal remodeling.
PTPRD may be one of a select group of tumor suppressor genes that are inactivated in a wide range of common tumor types.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5.
, protein tyrosine phosphatase, receptor type, delta polypeptide
, protein-tyrosine phosphatase delta
, receptor-type tyrosine-protein phosphatase delta