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DRD2 (zeige DRD2 Proteine) A2/A1, DRD3 (zeige DRD3 Proteine) Ser9Gly, DbetaH -1021C>T, OPRM1 (zeige OPRM1 Proteine) A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.
The findings reported here suggest that, in participants with the GRIK1 rs2832407*CC genotype, topiramate treatment enhances self-efficacy and reduces heavy drinking.
Findings indicate that SNPs in the GRIK1 gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
Results suggested that the extracellular N-terminal region including the two CUB domains was largely responsible for the distinct regulatory effects of Neto1 (zeige NETO1 Proteine) and Neto2 (zeige NETO2 Proteine) on the desensitization properties of GluK1 homomeric receptors
In the present study, we have shown that gene-gene interaction of components of different systems associated with nicotine reinforcing effects, such as OPRM1 (zeige OPRM1 Proteine) and GRIK1, rather than one gene polymorphism, is associated with smoking behavior.
This found that, among rs2832407*C of GRIK1 homozygotes, topiramate treatment produced the greatest reductions in the expected positive effects of drinking and desire to drink during the treatment period.
These results suggest that the effect of topiramate on drinking behavior, in which the GluK1-containing kainate receptor appears to play a key role, can be dissociated from its effect on weight.
Reduced Homer (zeige HOMER1 Proteine) binding to mGluR5 (zeige GRM5 Proteine) supports an inhibitory role for Homer (zeige HOMER1 Proteine) interactions with mGluR5 (zeige GRM5 Proteine) in mediating neuropathy.
Using the SNaPshot assay, we present evidence for allelic nondisjunction at rs363506 in the GRIK1 gene and rs2834235 and rs7283354 in the GARS-AIRS-GART gene in Down syndrome in India.
The association at rs455804 implicates GRIK1 as a novel susceptibility gene for HBV-related HCC (zeige FAM126A Proteine), suggesting the involvement of glutamate (zeige GRIN1 Proteine) signaling in the development of HBV-related HCC (zeige FAM126A Proteine).
Data (including data from in vitro studies using tissues from transgenic mice) suggest that vitamin D3 suppresses NMDA-receptor- (Grin1)-mediated and kainate-receptor- (Grik1)-mediated excitation of GnRH- (gonadotrophin-releasing hormone)-secreting neurons of pre-optic area of hypothalamus. These studies were conducted with brain slices from male and female mice in pre-pubertal period.
The cytoplasmic domain of the GluK2 (zeige GRIK2 Proteine) low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4 (zeige GRIK4 Proteine)/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
GluK5 is almost exclusively localized to the presynaptic ribbon of photoreceptor terminals.
Animals trained in the trace fear conditioning protocol exhibited a transient increase in unedited GRIK1 RNA in the amygdala, and their learning efficiency correlated with unedited RNA levels in CA1 (zeige CA1 Proteine).
results show that GluK1 and Go proteins are natural partners, accounting for the metabotropic effects of Kainate receptors.
integrity of Homer (zeige HOMER1 Proteine) scaffolds is essential for normal glur5-evoked endocannabinoid functioning
We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli
The combined loss of the AMPA (zeige GRIA3 Proteine) receptor auxiliary TARPg-2 subunit and the GluK5 subunit leads to early mouse lethality.
CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
these data further implicate Group 1 mGluR (zeige GRM8 Proteine) signaling through Homer2 (zeige HOMER2 Proteine) within the nucleus accumbens in excessive alcohol consumption
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG\; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
glutamate receptor, ionotropic, kainate 1
, glutamate receptor, ionotropic kainate 1
, excitatory amino acid receptor 3
, glutamate receptor 5
, glutamate receptor ionotropic, kainate 1
, glutamate receptor subunit 5