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Tid1 deficiency reduces ATP production.
Dnaja3 is crucial for mitochondrial biogenesis through its chaperone activity on Polga (zeige POLG Proteine) and has a role in preventing dilated cardiomyopathy
Tid1 is critical for early mammalian development, most likely for its function in sustaining embryonic-cell survival, which requires its association with Hsp70 (zeige HSP70 Proteine).
It is proposed that Tid1 contributes to cell aging by acting as a repressor of NF-kappa B (zeige NFKB1 Proteine) signaling.
Overexpression of the N-terminal half of Tid1 induced agrin (zeige AGRN Proteine)- and MuSK (zeige MUSK Proteine)-independent phosphorylation and clustering of AChRs. These results demonstrate that Tid1 is an essential component of the agrin (zeige AGRN Proteine) signaling pathway, crucial for synaptic development.
Impaired stoichiometry between mtHsp40 and mtHsp70 (zeige HSPA9 Proteine) promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function.
The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB (zeige NFKB1 Proteine) Signaling.
Tid1 increases autophagic flux by interacting with the Beclin 1-containing autophagy protein complex.
TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition
Tid1 acts as a tumor suppressor by inhibiting EGFR (zeige EGFR Proteine) signaling through interaction with EGFR (zeige EGFR Proteine)/HSP70 (zeige HSP70 Proteine)/HSP90 (zeige HSP90 Proteine) and enhancing EGFR (zeige EGFR Proteine) ubiquitinylation and degradation.
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1 (zeige DNM1L Proteine))-depedendent mitochondrial fragmentation and decreased cell viability.
loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin
Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 (zeige ERBB2 Proteine) protein, and that both are significant prognostic indicators of breast cancer patient survival.
findings denote hTid-1(S) as an essential regulatory component of MetR signaling
hTid1 negatively regulates the expression and transcriptional activity of STAT5b (zeige STAT5B Proteine) and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b (zeige STAT5B Proteine).
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
dnaJ homolog subfamily A member 3, mitochondrial
, DnaJ (Hsp40) homolog, subfamily A, member 3
, dnaJ protein Tid-1
, tumorous imaginal discs protein Tid56 homolog
, hepatocellular carcinoma-associated antigen 57