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Results suggest that xCOUP-TF and xCyp26 (zeige CYP26A1 ELISA Kits) are both regulated by Wnt (zeige WNT2 ELISA Kits) signaling, and cooperatively function in retinoic acid (RA) signaling to affect anterior-posterior (A-P) neural patterning.
Both in zebrafish and Xenopus the development of the main lymphatic structures was severely hampered.
Whole-exome sequencing identified a novel missense NR2F1 (zeige NR2F1 ELISA Kits) variant in each case, Cys86Phe in the DNA-binding domain in Case 1, and a Leu372Pro in the ligand-binding domain in Case 2. Using molecular modeling we are also able to demonstrate the putative effect of the two missenses on protein function, generating a hitherto undescribed molecular model for the ligand-binding domain of NR2F1 (zeige NR2F1 ELISA Kits) in the process.
We conclude that COUP-TFII mutations can cause diaphragmatic hernias, and should be included in the differential diagnosis of CDH (zeige CHDH ELISA Kits) patients, particularly those with comorbid congenital heart defects.
Studied the role of Nuclear receptor subfamily 2 group F member 2 (NR2F2) in MSC (zeige MSC ELISA Kits) chondrogenesis in bioprinted cartilage. NR2F2 (zeige NR2F1 ELISA Kits) over-expressed MSCs showed significantly enhanced chondrogenesis while NR2F2 (zeige NR2F1 ELISA Kits) knockdown cells demonstrated the exactly opposite behavior.
NR2F2 (zeige NR2F1 ELISA Kits) is a Direct Target Gene of miR (zeige MLXIP ELISA Kits)-382 in colorectal cancer.
Results indicate that COUP-TFII may play an oncogenic role in RCC, and COUP-TFII may promote tumor progression through inhibiting BRCA1.
MicroRNA-27b was targeted and down-regulated by NR2F2 (zeige NR2F1 ELISA Kits) in human gastric cancer tissues and cells.
NR2F2 (zeige NR2F1 ELISA Kits) could promote TGF-beta (zeige TGFB1 ELISA Kits)-induced epithelial-mesenchymal transition of colorectal carcinoma cells and inhibit Smad7 (zeige SMAD7 ELISA Kits) expression via transactivation of miR (zeige MLXIP ELISA Kits)-21.
NR2F2 (zeige NR2F1 ELISA Kits) mediates BMMSCinduced proliferation of Reh (zeige CES1 ELISA Kits) cells, partially via regulation of VEGFA (zeige VEGFA ELISA Kits). Disrupting microenvironmental support by targeting NR2F2 (zeige NR2F1 ELISA Kits) may be a potential therapeutic strategy for ALL.
miR (zeige MLXIP ELISA Kits)-382 inhibits prostate cancer cell proliferation and metastasis through inhibiting COUPTFII.
Positive COUP-TF II expression levels has significant value in determining CRC (zeige CALR ELISA Kits) stage and metastasis and cooperates with negative Smad4 (zeige SMAD4 ELISA Kits) expression contributing to assess prognosis in patients with colorectal cancer.
elimination of Wolffian ducts in female embryos is actively promoted by COUP-TFII, which suppresses a mesenchyme-epithelium cross-talk responsible for Wolffian duct maintenance.
Together, these results imply that Tie2 (zeige TEK ELISA Kits) is essential for venous specification and maintenance via Akt (zeige AKT1 ELISA Kits) mediated stabilization of COUP-TFII.
Coup-TF1 (zeige NR2F1 ELISA Kits) and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
A regulatory role of COUP-TFII in the development of muscular dystrophy.
FGF2 (zeige FGF2 ELISA Kits) is an extracellular inducer of COUP-TFII expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII expression prior to the onset of osteogenic differentiation
results identify a novel cooperation between MEF2 (zeige MEF2C ELISA Kits) factors and NR2F2 in the expression of the Akr1c14 gene
These in vitro and in vivo data support an anti-adipogenic role of COUP-TFII via downregulating the Notch (zeige NOTCH1 ELISA Kits) signaling target gene Hey1 (zeige HEY1 ELISA Kits).
Myocardial Nr2f2 overexpression causes heart failure. Nr2f2 represses genes critical for mitochondrial ETC enzyme activity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased ROS (zeige ROS1 ELISA Kits) and lower rates of oxygen consumption.
Data show that Chicken ovalbumin upstream promoter transcription factor (zeige NR2F1 ELISA Kits) II (COUP-TFII)-induced expression of Neuropilin-2 (Nrp2 (zeige NRP2 ELISA Kits)) and its down-regulation control the destination of preoptic area (POa)-derived GABAergic neurons.
These data demonstrate that Nr2f2 is a direct target of POU4F3 (zeige POU4F3 ELISA Kits) in vitro and that this regulatory relationship may be relevant to hair cell development and survival.
Sox7 (zeige SOX7 ELISA Kits)/18 factors and Notch (zeige NOTCH1 ELISA Kits) regulate nr2f2 gene expression during venous differentiation in zebrafish.
absence of NR2F2 in zebrafish resulted in distinct vascular defects including loss of venous marker expression, major trunk vessel fusion and vascular leakage.
Results show that chicken ovalbumin upstream promoter transcription factor (zeige NR2F1 ELISA Kits) II (COUP-TFII), hepatocyte nuclear factor 4alpha (HNF-4alpha (zeige HNF4A ELISA Kits)) and HNF-4gamma regulate growth hormone receptor (zeige GHR ELISA Kits) 1A promoter activity by binding to a common DNA element
Involvement of Ad4BP/SF-1 (zeige NR5A1 ELISA Kits), DAX-1 (zeige NR0B1 ELISA Kits), and COUP-TFII transcription factor on steroid production and luteinization in ovarian theca cells.
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
nuclear receptor subfamily 2, group F, member 2
, ADP-ribosylation factor related protein 1
, COUP transcription factor 2
, COUP transcription factor II
, apolipoprotein A-I regulatory protein 1
, apolipoprotein AI regulatory protein 1
, chicken ovalbumin upstream promoter transcription factor 2
, chicken ovalbumin upstream promoter-transcription factor I
, chicken ovalbumin upstream promoter-transcription factor II variant 1
, chicken ovalbumin upstream promoter-transcription factor II variant 2
, chicken ovalbumin upstream promoter-transcription factor II variant 3
, COUP-TF II
, apolipoprotein regulatory protein 1
, ovalbumin upstream promoter beta nuclear receptor
, seven-up related 40
, nuclear receptor subfamily 2 group F member 2
, apolipoprotein A1 regulatory protein 1
, nuclear receptor subfamily 2, group F, member 1
, transcription factor COUP 2