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BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Bmp7 gradients steer nerve growth cones by a balancing act of limk1 and SSH on AD/cofilin.
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
these data support a model in which Tfap2a, acting through Bmp7a, modulates Fgf and Notch signaling to control the duration, amount and speed of SAG neural development.
maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry
Cloning and expression of a second zebrafish bmp7 homolog, bmp7b.
prognostic marker in oral squamous cell carcinoma
Study results indicated that BMP7 serves a key function in regulating the progression of small-cell lung cancer.
in this study, the influence of IGF-1 and BMP-7 in different concentrations on the osteogenic differentiation of two human MSC-subtypes, isolated from reaming debris (RMSC) and iliac crest bone marrow (BMSC) has been assessed
BMP7 contributes to epithelial-to-mesenchymal transition-like responses and plays a role equivalent to TGF-β in the course of corneal wound healing.
In contrast to BMP-2, BMP-7 concomitantly inhibited the expression of profibrotic genes
On the contrary, BMP7 specific antibody inhibits the HNK-induced activation of p53 in colon cancer cells and partly decreases the total level of p53. Our findings suggested that HNK may be a promising anticancer drug for CRC; activation of p53 plays an important role in the anticancer activity of HNK, which may be initialized partly by the HNK-induced upregulation of BMP7.
All isoforms of type I and type II BMP receptors were expressed in both Ca9-22 and HSC3 cells and BMP7 stimulation resulted in the phosphorylation of Smad1/5/8 in both cell lines
the results of the present study indicate that BMP7 may inhibit excessive scar formation via activation of the BMP7/Smad1/5/8 signaling pathway.
BMP7, in particular combined with MSC, seems to have a favourable application also in periodontal regeneration.
Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings.
Implantation of morphogenetic protein-7 (BMP-7) gene activated fat tissue fragments can elicit regeneration of large bone defects in rats and could become a clinically expeditious strategy for in vivo bone tissue engineering.
the present results showed that OP-1 might serve as a biochemical parameter for determining disease severity in primary knee Osteoarthritis (OA). Further studies with larger sample size need to be carried out to confirm OP-1 as a marker of disease status. Studies are required to be done to examine the genetic and lifestyle factors that may contribute to the development of knee OA
BMP7-Based Functionalized Self-Assembling Peptides Protect Nucleus Pulposus-Derived Stem Cells From Apoptosis In Vitro
results showed that the expression of cartilage-associated markers in ESC-MSCs induced by the TGFbeta1 and BMP7 combination was increased compared to induction with TGFbeta1 alone. The TGFbeta1 and BMP7 combination upregulated the expression of TGFbeta receptor and the production of endogenous TGFbetas compared to TGFbeta1 induction.
Overexpression of truncated ALK5 in a B-cell line counteracted BMP-7-induced apoptosis, whereas overexpression of truncated ALK4 had no effect.
study suggests that the common genetic polymorphisms of BMP7 gene are not major contributors to variations in Bone Mineral Density or osteoporotic fracture in postmenopausal Chinese women.
Patients with hereditary pulmonary arterial hypertension had significantly higher BMP7 concentrations than patients with idiopathic pulmonary arterial hypertension and control subjects.
Expression of bone morphogenetic protein 7 ligand was significantly increased in patients with abnormal uterine bleeding. Study demonstrates that bone morphogenetic protein 7 is a promising target for future investigation and pharmacologic treatment of abnormal uterine bleeding.
BMP-7 directly upregulates adhesion and migration of human monocytic cells via activation of beta 2 integrins, Akt, and FAK.
results showed that stimulation by BMP-7 leads to an increased osteogenic potential of Mesenchymal stem cells.
PTEN is a negative regulator of PI3K and BMP-7 increased PTEN expression in vivo and in vitro. These data demonstrate an important mechanism by which BMP-7 orchestrates renal protection through Akt inhibition and highlights Akt inhibitors as anti-fibrotic therapeutics.
analysis of the mechanisms involved revealed the induction of bone morphogenetic protein-7 (BMP7) expression, a critical regulator of angiogenesis and kidney homeostasis, through a PDE5i-dependent downregulation of miR-22. In conclusion PDE5i slows the progression of Diabetic Nephropathy (DN) in mice, improving hemodynamic parameters and vessel
Report a novel positive function of mm9_circ_009056 during osteogenesis in regulating BMP7 through miR-22-3p. Furthermore, the expression of mm9_circ_009056 was up-regulated in CGRP-induced cells, whereas miR-22-3p was decreased.
BMP 7 is a key regulator of Tmem100-mediated cell proliferation in metanephric mesenchymal cells.There is a complicated regulation network among Tmem100, BMP7, and BMPR-II in mouse embryonic kidney-derived cells.
Overexpression of miR-384-5p significantly decreased BMP7 protein, while depletion of miR-384-5p significantly increased BMP7 protein in renal epithelial cells.
Bone morphogenetic protein 7 (BMP7) exerts differential effects depending on the concentration; it may expand mesenchymal cells in the stroma where BMP7 concentration is low and may upregulate cadherin-11 promoting condensation around the tip of ureteric buds.
BMP-7 therefore is an attractive candidate for tackling a multifaceted disease such as diabetes, since it not only reduces body fat, but also strengthens insulin signaling, causing improved glucose uptake and ameliorating peripheral insulin resistance.
Our studies indicate that BMP7 is an important factor during the process of implantation that contributes to healthy embryonic development.
Western blot analysis demonstrated that following BMP2 and BMP7 cotransfection of MC3T3E1 cells, the protein expression levels of BMP2, BMP4, BMP6, BMP7, BMP9 and Wnt3a were increased compared with control cells
The disequilibrium between BMP-7 and TGF-beta signals plays a relevant role in the LV remodelling response to haemodynamic stress in mice subjected to transverse aortic constriction leading to left ventricular hypertrophy/dysfunction.
the in vivo inter-relationships between Bmp7 and Usag-1, was examined.
only BMP7, not BMP2 or BMP4, is necessary for interdigital programmed cell death
odontoblast beta-catenin signaling may act through regulation of BMP signaling to maintain the integrity of HERS cells
BMP7 and FGF9 coordinately regulate AP-1 transcription to promote G1-S cell cycle progression and nephron progenitor cells proliferation.
Gdf-5 induced the expression of the alpha5 sub-unit, while Bmp-7 induced the expression of the alphaV sub-unit.
MiR-22 promotes the development of liver cirrhosis through BMP7 suppression.
BMP7 induced changes in levels of mRNA and proteins associated with reactive gliosis in retinal astrocytes and Muller glial cells, including glial fibrillary acidic protein, glutamine synthetase, chondroitin sulfate proteoglycans and MMPs.
We found that the recruited macrophages are polarized to a M2 subtype after renal injury. M2 macrophages released high levels TGFb1 to suppress BMP7 to enhance EMT-induced renal fibrosis.
Bmp4, Bmp7 and bmpr2 signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.
the BMP4 prodomain is necessary and sufficient to generate stable BMP4/7 heterodimers
Study detected a 5-bp insertion-deletion at 602 bp upstream from the transcription start site of the BMP7 gene promoter among 258 pigs of 3 breeds; based on correlation analysis, the 5-bp indel site does not significantly affect porcine reproductive traits.
These results suggest that g.35161T>C is a potential candidate gene locus for litter size traits and the BMP7 gene might be associated with the quantitative trait locus controlling the litter size.
the combined treatment with TGF-beta1 and BMP-7 or treatment first with TGF-beta1 followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP secretion.
Some single nucleotide polymorphisms and haplotypes in BMP7 are associated with cattle growth traits.
Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.
BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration.
Data show that BMP-2, BMP-4, and BMP-7, noggin, and chordin were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity.
bone morphogenetic protein 7 (osteogenic protein 1)
, bone morphogenetic protein 7
, osteogenic protein 1
, bone moorphogenic protein-7