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BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.
Bmp7 gradients steer nerve growth cones by a balancing act of limk1 (zeige LIMK1 Proteine) and SSH on AD/cofilin (zeige CFL1 Proteine).
Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation
these data support a model in which Tfap2a (zeige TFAP2A Proteine), acting through Bmp7a, modulates Fgf and Notch (zeige NOTCH1 Proteine) signaling to control the duration, amount and speed of SAG (zeige SAG Proteine) neural development.
maternally supplied Smad5 (zeige SMAD5 Proteine) is already required to mediate ventral specification prior to zygotic Bmp2 (zeige BMP4 Proteine)/7 signaling to establish the initial dorsoventral asymmetry
Cloning and expression of a second zebrafish bmp7 homolog, bmp7b.
On the contrary, BMP7 specific antibody inhibits the HNK-induced activation of p53 (zeige TP53 Proteine) in colon cancer cells and partly decreases the total level of p53 (zeige TP53 Proteine). Our findings suggested that HNK may be a promising anticancer drug for CRC (zeige CALR Proteine); activation of p53 (zeige TP53 Proteine) plays an important role in the anticancer activity of HNK, which may be initialized partly by the HNK-induced upregulation of BMP7.
All isoforms of type I and type II BMP receptors were expressed in both Ca9 (zeige CA9 Proteine)-22 and HSC3 cells and BMP7 stimulation resulted in the phosphorylation of Smad1 (zeige GARS Proteine)/5/8 in both cell lines
the results of the present study indicate that BMP7 may inhibit excessive scar formation via activation of the BMP7/Smad1 (zeige GARS Proteine)/5/8 signaling pathway.
BMP7, in particular combined with MSC (zeige MSC Proteine), seems to have a favourable application also in periodontal regeneration.
Synergistic effects of BMP-2 (zeige BMP2 Proteine), BMP-6 (zeige BMP6 Proteine) or BMP-7 with human plasma fibronectin (zeige FN1 Proteine) onto hydroxyapatite coatings.
Implantation of morphogenetic protein-7 (BMP-7) gene activated fat tissue fragments can elicit regeneration of large bone defects in rats and could become a clinically expeditious strategy for in vivo bone tissue engineering.
the present results showed that OP-1 might serve as a biochemical parameter for determining disease severity in primary knee Osteoarthritis (OA). Further studies with larger sample size need to be carried out to confirm OP-1 as a marker of disease status. Studies are required to be done to examine the genetic and lifestyle factors that may contribute to the development of knee OA
BMP7-Based Functionalized Self-Assembling Peptides Protect Nucleus Pulposus-Derived Stem Cells From Apoptosis In Vitro
results showed that the expression of cartilage-associated markers in ESC-MSCs induced by the TGFbeta1 (zeige TGFB1 Proteine) and BMP7 combination was increased compared to induction with TGFbeta1 (zeige TGFB1 Proteine) alone. The TGFbeta1 (zeige TGFB1 Proteine) and BMP7 combination upregulated the expression of TGFbeta (zeige TGFB1 Proteine) receptor and the production of endogenous TGFbetas compared to TGFbeta1 (zeige TGFB1 Proteine) induction.
Overexpression of truncated ALK5 (zeige TGFBR1 Proteine) in a B-cell line counteracted BMP-7-induced apoptosis, whereas overexpression of truncated ALK4 (zeige ACVR1B Proteine) had no effect.
Overexpression of miR (zeige MLXIP Proteine)-384-5p significantly decreased BMP7 protein, while depletion of miR (zeige MLXIP Proteine)-384-5p significantly increased BMP7 protein in renal epithelial cells.
Bone morphogenetic protein 7 (BMP7) exerts differential effects depending on the concentration; it may expand mesenchymal cells in the stroma where BMP7 concentration is low and may upregulate cadherin-11 promoting condensation around the tip of ureteric buds.
BMP-7 therefore is an attractive candidate for tackling a multifaceted disease such as diabetes, since it not only reduces body fat, but also strengthens insulin (zeige INS Proteine) signaling, causing improved glucose uptake and ameliorating peripheral insulin (zeige INS Proteine) resistance.
Our studies indicate that BMP7 is an important factor during the process of implantation that contributes to healthy embryonic development.
Western blot analysis demonstrated that following BMP2 (zeige BMP2 Proteine) and BMP7 cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (zeige BMP2 Proteine), BMP4 (zeige BMP4 Proteine), BMP6 (zeige BMP6 Proteine), BMP7, BMP9 (zeige GDF2 Proteine) and Wnt3a (zeige WNT3A Proteine) were increased compared with control cells
The disequilibrium between BMP-7 and TGF-beta (zeige TGFB1 Proteine) signals plays a relevant role in the LV remodelling response to haemodynamic stress in mice subjected to transverse aortic constriction leading to left ventricular hypertrophy/dysfunction.
the in vivo inter-relationships between Bmp7 and Usag-1 (zeige SOSTDC1 Proteine), was examined.
only BMP7, not BMP2 (zeige BMP2 Proteine) or BMP4 (zeige BMP4 Proteine), is necessary for interdigital programmed cell death
odontoblast beta-catenin signaling may act through regulation of BMP signaling to maintain the integrity of HERS cells
BMP7 and FGF9 coordinately regulate AP-1 (zeige JUN Proteine) transcription to promote G1-S cell cycle progression and nephron progenitor cells proliferation.
Study detected a 5-bp insertion-deletion at 602 bp upstream from the transcription start site of the BMP7 gene promoter among 258 pigs of 3 breeds; based on correlation analysis, the 5-bp indel site does not significantly affect porcine reproductive traits.
These results suggest that g.35161T>C is a potential candidate gene locus for litter size traits and the BMP7 gene might be associated with the quantitative trait locus controlling the litter size.
the combined treatment with TGF-beta1 (zeige TGFB1 Proteine) and BMP-7 or treatment first with TGF-beta1 (zeige TGFB1 Proteine) followed by BMP-7 was more effective than other treatment groups in both chondrogenic differentiation and SZP (zeige PRG4 Proteine) secretion.
Some single nucleotide polymorphisms and haplotypes in BMP7 are associated with cattle growth traits.
Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (zeige DFFB Proteine)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 (zeige BMP4 Proteine) inhibits the release of CAD.
BMP7 enhances the effect of BMSCs on extracellular matrix remodeling in a rabbit model of intervertebral disc degeneration.
Data show that BMP-2 (zeige BMP2 Proteine), BMP-4 (zeige BMP4 Proteine), and BMP-7, noggin (zeige NOG Proteine), and chordin (zeige CHRD Proteine) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity.
bone morphogenetic protein 7 (osteogenic protein 1)
, bone morphogenetic protein 7
, osteogenic protein 1
, bone moorphogenic protein-7