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Cow (Bovine) Polyclonal ARF6 Primary Antibody für IHC, WB - ABIN2785790
Karim, Choi, Whiteheart: Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. in The Journal of biological chemistry 2008
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This study identifies a novel regulatory crosstalk between Ral (zeige rala Antikörper) and Arf6 that controls Ral (zeige rala Antikörper) function in cells.
ARHGAP24 (zeige ARHGAP24 Antikörper) may regulate pseudopod formation downstream of activated ARF6 in MDA-MB-231 human breast carcinoma cells.
ARF6 was a downstream target of Kras/ERK (zeige EPHB2 Antikörper) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (zeige F3 Antikörper) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (zeige RAB35 Antikörper) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
Data suggest that activated ARF6 controls GNAQ (zeige GNAQ Antikörper) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
expression and activation of LHCGR (zeige LHCGR Antikörper) and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR (zeige LHCGR Antikörper) internalization is unaltered
The Squamous cell carcinoma of the tongue cell line SCC (zeige CYP11A1 Antikörper)-9, which overexpress Arf6 and AMAP1 (zeige ASAP1 Antikörper), also expressed EPB41L5 (zeige EPB41L5 Antikörper) at high levels to promote invasiveness, whereas the weakly invasive SCC (zeige CYP11A1 Antikörper)-25 cells did not express EPB41L5 (zeige EPB41L5 Antikörper) at notable levels.
The present study demonstrated that the Arf6-specific GAP ACAP3 (zeige Acap3 Antikörper) plays a crucial role in neuronal migration through regulating morphological changes of neurons at intermediate zone of developing cerebral cortex.
Study demonstrates that Arf6 regulates neuronal migration in the intermediate zone through the FIP3 (zeige IKBKG Antikörper)-dependent trafficking of endosomes containing N-cadherin (zeige CDH2 Antikörper) during cortical layer formation.
The results show that ARNO (zeige CYTH2 Antikörper) interaction with the RLIP76 (zeige RALBP1 Antikörper) N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 (zeige RALBP1 Antikörper) control of Rac (zeige AKT1 Antikörper).
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (zeige DMD Antikörper)-associated glycoprotein complex (DGC (zeige GGCX Antikörper)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (zeige GGCX Antikörper).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 (zeige Acap3 Antikörper) in concert with a guanine-nucleotide-exchange factor (zeige ARHGEF12 Antikörper)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (zeige ABCA1 Antikörper) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (zeige ABCA1 Antikörper) recycling and efflux of intracellular cholesterol.
These findings suggest that SDCCAG3 (zeige SDCCAG3 Antikörper) might function in endosomal trafficking downstream of Arf6.
both Arf6 activation through GluN2B (zeige GRIN2B Antikörper)-BRAG1 (zeige IQSEC2 Antikörper) during early development and the transition from BRAG1 (zeige IQSEC2 Antikörper)- to BRAG2 (zeige IQSEC1 Antikörper)-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP-ribosylation factor 6
, ADP-ribosylation factor-like 6
, ADP-ribosylation factor-like protein 6