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1 | ABIN320631 | WB | Rabbit | IgG | N-Term | Anmelden zum Anzeigen | Polyclonal | 0 |
General |
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Antigen | Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Antikörper |
Epitop | N-Term Alternativen |
Reaktivität | Rind (Kuh), Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Schaf Alternativen |
Wirt | Kaninchen Alternativen |
Klonalität | |
Konjugat | Unkonjugiert Alternativen |
Applikation |
Western Blotting (WB)
Alternativen
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1 Publikation vorhanden |
Hersteller | Anmelden zum Anzeigen |
ProduktdetailsAntigendetails Anwendungsinformationen Handhabung Referenzen Bilder |
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Blocking Peptide | Zu diesem Produkt passt das Blocking Peptide ABIN978258. |
Sequenz | ERWPWPSGGA WLLVAARALL QLLRSDLRLG RPLLAALALL AALDWLCQRL |
Homologie | Cow: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100% |
Produktmerkmale | This is a rabbit polyclonal antibody against HSD11B2. It was validated on Western Blot using a cell lysate as a positive control. |
Reinigung | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B2 |
AntigendetailsProduktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | HSD11B2 (HSD11B2 Antibody Abstract) |
Hintergrund |
HSD11B2 catalyzes the conversion of cortisol to the inactive metabolite cortisone. It modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Alias Symbols: AME, AME1, HSD11K, HSD2, SDR9C3 Protein Interaction Partner: KAT2B, HDAC1, KAT2A, CTBP1, Protein Size: 44 |
Molekulargewicht | 45 kDa |
Gen-ID | 3291 |
NCBI Accession | NM_000196, NP_000187 |
UniProt | P80365 |
Pathways | Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones |
AnwendungsinformationenProduktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben |
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Applikationshinweise | Optimal working dilutions should be determined experimentally by the investigator. |
Kommentare |
Antigen size: 44 AA |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben |
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Format | Liquid |
Konzentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Konservierungsmittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handhabung | Avoid repeated freeze-thaw cycles. |
Lagerung | -20 °C |
Informationen zur Lagerung | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ReferenzenProduktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Allgemeine Veröffentlichungen |
Subtil-Rodríguez, Millán-Ariño, Quiles, Ballaré, Beato, Jordan: "Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking." in: Molecular and cellular biology, Vol. 28, Issue 11, pp. 3830-49, 2008 |
BilderProduktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben |
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Bilder des Herstellers |