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Curcumin treatments considerably increased the expression of AKR1C2 in prostate cancer cell lines.
Data show that increased levels of AKR1C1 (zeige DDH Proteine)/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 and HSD11B1 (zeige HSD11B1 Proteine), and increased estrogen levels could be linked to increased adiposity-related expression of aromatase (zeige CYP19A1 Proteine) in adipose tissue.
the present study suggests that AKR1C1 (zeige DDH Proteine), AKR1C2, AKR1C3 (zeige AKR1C3 Proteine), and AKR1C4 (zeige AKR1C4 Proteine) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 (zeige MTDH Proteine) and AKR1C2.
Identify two novel factors, AKR1C2 (positive factor) and NF1 (zeige NF1 Proteine) (negative factor), as the AEG-1 (zeige MTDH Proteine) downstream players in the process of metastasis in liver cancer.
The endogenous HMOX1 (zeige HMOX1 Proteine) gene but not the AKR1C2 gene is strongly repressed by Bach1 (zeige BACH1 Proteine) in HaCaT keratinocytes.
In model cell lines of endometrial cancer, AKR1C2 and SRD5A1 (zeige SRD5A1 Proteine) have crucial roles in progesterone metabolism.
Significantly higher levels of SRD5A1 (zeige SRD5A1 Proteine), AKR1C2, AKR1C3 (zeige AKR1C3 Proteine), and HSD17B10 (zeige HSD17B10 Proteine) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
The V54L mutation significantly decreases the 3alpha-hydroxysteroid dehydrogenase activity of DDH2 for the reduction of dihydrotestosterone.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
, aldo-keto reductase family 1 member C2
, chlordecone reductase homolog HAKRD
, dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
, pseudo-chlordecone reductase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II dihydrodiol dehydrogenase
, 17-alpha-hydroxysteroid dehydrogenase
, 3(or 17)-alpha-hydroxysteroid dehydrogenase
, 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C21
, aldo-keto reductase family 1, member C21