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Human SMAD1 Protein expressed in Wheat germ - ABIN1320591
Andrews, Schneider, Yang, Michaels, Chen, Tang, Emkey: Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays. in Assay and drug development technologies 2010
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Data show that interplay of Smad1/5 and MAP kinase (zeige MAPK1 Proteine) signaling system (ERK (zeige MAPK1 Proteine) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (zeige SMAD9 Proteine) act redundantly to each other downstream of smad5 (zeige SMAD5 Proteine) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (zeige SMAD5 Proteine).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 retrotransposon contains the MAD protein (zeige MXD1 Proteine) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (zeige GRIN2A Proteine) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (zeige TGFb Proteine) and Wnt (zeige WNT4 Proteine) pathways depending on its phosphorylation state.
Yorkie (zeige YAP1 Proteine) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (zeige TGFb Proteine) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
Data show that miR (zeige MLXIP Proteine)-26b-5p suppresses Twist1 (zeige TWIST1 Proteine)-induced EMT (zeige ITK Proteine), invasion, and metastasis of HCC (zeige FAM126A Proteine) cells by targeting SMAD1 (zeige GARS Proteine).
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (zeige SRC Proteine) and ERK1/2 inhibitors or by the knockdown of Smad1 (zeige GARS Proteine).
Low doses of IL1B (zeige IL1B Proteine) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (zeige IL1B Proteine) inhibit BMP/Smad signaling through the activation of NF-kappaB (zeige NFKB1 Proteine) and MAPK (zeige MAPK1 Proteine) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (zeige GARS Proteine) signaling pathway and inhibits Col (zeige HDAC1 Proteine) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (zeige SMAD7 Proteine) and both zeta-chain-associated protein kinase (zeige CDK7 Proteine) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (zeige SMAD2 Proteine)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (zeige GARS Proteine)/8 and lower SMAD-4 (zeige SMAD4 Proteine) expression in chronic lymphocytic leukemia cells
melatonin treatment was found to downregulate TNFalpha (zeige TNF Proteine)-induced SMURF1 (zeige SMURF1 Proteine) expression and then decrease SMURF1 (zeige SMURF1 Proteine)-mediated ubiquitination and degradation of SMAD1 (zeige GARS Proteine) protein
The expression of specific targets Smad1 (zeige GARS Proteine) and Osterix (zeige SP7 Proteine) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (zeige MUC7 Proteine)+). As miR (zeige MLXIP Proteine)-30b, miR (zeige MLXIP Proteine)-133a, and miR (zeige MLXIP Proteine)-143 are negatively regulated by Pi and restored by Mg(2 (zeige MUC7 Proteine)+) with a congruent modulation of their known targets Runx2 (zeige RUNX2 Proteine), Smad1 (zeige GARS Proteine), and Osterix (zeige SP7 Proteine), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
the BMP-2 (zeige BMP2 Proteine)/Smad1 (zeige GARS Proteine)/5/RUNX2 (zeige RUNX2 Proteine) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (zeige BGLAP Proteine) synth
Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (zeige GARS Proteine).
The expression SMAD1 (zeige GARS Proteine) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).
TGF-beta1 (zeige TGFB1 Proteine)-induced pSmad1 levels were elevated in Nedd4-deficient primary VSMCs isolated from Nedd4(fl/fl (zeige FLT3LG Proteine)) ;SM22alpha (zeige TAGLN Proteine)-Cre mice.
AA-enhanced cardiomyogenesis thus relies on the ability of AA to modulate the ratio of SMAD signaling among the TGFbeta (zeige TGFB1 Proteine)-superfamily receptor signaling pathways
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (zeige RUNX2 Proteine)) expression through S1PR2 (zeige S1PR2 Proteine)/RhoA (zeige RHOA Proteine)/ROCK/Smad1/5/8 signaling.
these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
We discovered that Smad1/5/4-Amhr2 (zeige AMHR2 Proteine)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (zeige AMHR2 Proteine)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (zeige TGFB1 Proteine)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (zeige YAP1 Proteine) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (zeige BMP2 Proteine)-YAP (zeige YAP1 Proteine)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
Dynamin (zeige DNM1 Proteine)-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2 (zeige BMP2 Proteine)) and its receptors is dispensable for the initiation of Smad signaling
Thyroid-specific Smad1 and Smad5 (zeige SMAD5 Proteine) double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 and Smad5 (zeige SMAD5 Proteine) have overlapping functions to govern hepcidin (zeige HAMP Proteine) transcription. Moreover, erythropoietin (zeige EPO Proteine) and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin (zeige HAMP Proteine) expression.
interactions between miR (zeige MYLIP Proteine)-26 and the Smad1 3'UTR modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1