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CD36 (zeige CD36 Proteine) is a major mediator of FA-induced release of CCK (zeige CCK Proteine) and secretin. These peptides contribute to the role of CD36 (zeige CD36 Proteine) in fat absorption and to its pleiotropic metabolic effects.
Data suggest that the interaction between secretin peptide residue H1 and secretin receptor (zeige SCTR Proteine) residue W274 is most compatible with a hydrophobic interaction.
a lineage of mature enteroendocrine cells have the ability to coexpress members of a group of functionally related peptides: CCK (zeige CCK Proteine), secretin, GIP (zeige GIP Proteine), GLP-1 (zeige GCG Proteine), PYY, and neurotensin (zeige NTS Proteine)
Secretin effect on increase in transcription of the tyrosine hydroxylase (Th (zeige TH Proteine)) gene and modulate catecholamine secretion, was tested.
binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor (zeige SCTR Proteine)
secretin significantly inhibited the tumor size and more than doubled tumor latency, which was associated with a decrease in proliferating cell nuclear antigen (zeige PCNA Proteine) and an increase in cleaved-caspase 3 (zeige CASP3 Proteine) expression levels
The purpose of this study was to investigate whether secretin exhibits similar properties in vitro by forming micelles in aqueous solution and interacting with phospholipids
Human VPAC1 receptor (zeige VIPR1 Proteine) selectivity filter; Identification of a critical domain for restricting binding
human secretin gene is controlled by the Sp1/Sp3 transcription factors ratio and the methylation status of the promoter
Transgenic mouse study suggests a trophic role for secretin on neurons known to be involved in multiple superior functions in the normal brain, and lost in neurodegenerative disorders.
synthetic porcine and human forms of secretin are equivalent to one another and to biologic porcine secretin and can be used interchangeably in pancreatic function testing
The increased calcium response mediated by secretin in the absence of GLP-1R (zeige GLP1R Proteine) was paralleled by an increased glucose-dependent insulin (zeige INS Proteine) response, indicating that the heterodimeric receptor complexes modulate secretin responses.
Study demonstrates that secretin-induced dendritic oxytocin release from supraoptic neurons enhances social recognition. The newly defined secretin-oxytocin system may lead to a possible treatment for social deficits.
Secretin expression is not detected under delayed implantation but is stimulated after estrogen activation and under artificial decidualization.
Results suggest a role in motor coordination and motor learning for SCT expressed in cerebellar Purkinje cells
a novel positive feedback pathway involving secretin and CD36 (zeige CD36 Proteine) to enhance intestinal lipid absorption is being proposed.
in vitro lipolytic effects of Sct
The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
secretin is not required for normal pancreatic development or adaptive growth mediated by CCK (zeige CCK Proteine).
Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion.
, secretin precursor variant 1