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anti-Human PLA2G2A Antikörper:
anti-Rat (Rattus) PLA2G2A Antikörper:
anti-Mouse (Murine) PLA2G2A Antikörper:
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Human Polyclonal PLA2G2A Primary Antibody für ELISA, WB - ABIN4345941
Villanueva, Little, Lambeau, Klegeris: Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells. in Molecular and cellular neurosciences 2012
High PLA2 (zeige YWHAZ Antikörper) activity is associated with West Nile virus infection.
A lipidomics-based LC/MS assay was used to define the specificity of cPLA2 (zeige PLA2G4A Antikörper), iPLA2 (zeige PLA2G6 Antikörper), and sPLA2 toward a variety of phospholipids. A unique hydrophobic binding site for the cleaved fatty acid dominates each enzyme's specificity rather than its catalytic residues and polar headgroup binding site.
demonstration of an independent association between early-stage atherosclerosis and increased levels of sPLA2-IIa, implying that increased sPLA2-IIa may have a role in early-stage atherosclerosis in MetS (zeige ETV3 Antikörper) patients
these results suggest that PLA2G2A polymorphisms are involved in the risk of developing metabolic syndrome and type 2 diabetes mellitus and are associated with subclinical atherosclerosis in this group of patients
PLA2G2A has a previously undiscovered impact on insulin (zeige INS Antikörper) sensitivity and metabolism
lipidomic analyses revealed that sequestration of PUFAs in LDs by sPLA2-induced TAG remodelling and retention of PUFAs in LDs by inhibition of ATGL (zeige PNPLA2 Antikörper)-mediated TAG lipolysis protect from PUFA lipotoxicity.
This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
Given an aberrant high level of sPLA2IIa in the tumor microenvironment that should be much higher than that in the blood, our findings support the notion that sPLA2IIa functions as a ligand for EGFR (zeige EGFR Antikörper) family receptors and supports CSC properties via HER/ERBB (zeige EGFR Antikörper)-elicited signaling, which may contribute to resistance to therapy and cancer progression
the activity of human cPLA2alpha (zeige PLA2G4A Antikörper) towards a multitude of glycerophospholipids species present in micelles or bilayers, was investigated.
Mutational analysis of functional sites showed that both peroxidase and PLA2 (zeige YWHAZ Antikörper) active sites were necessary for mutant Prdx6 (zeige PRDX6 Antikörper) function, and that Prdx6 (zeige PRDX6 Antikörper) phosphorylation (at T177 residue) was essential for optimum PLA2 (zeige YWHAZ Antikörper) activity.Mutant Prdx6 (zeige PRDX6 Antikörper) at its Sumo1 (zeige SUMO1 Antikörper) sites escapes and abates this adverse process by maintaining its integrity and gaining function
transgenic mice overexpressing sPLA2 -IIA keratinocytes showed enhanced activation of EGFR (zeige EGFR Antikörper) and JNK1 (zeige MAPK8 Antikörper)/2 that led to c-Jun (zeige JUN Antikörper) activation.
PLA2 promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (zeige YWHAZ Antikörper), lipoxygenase and cyclooxygenase.
Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (zeige PLA2G6 Antikörper)) and Group X Secreted Phospholipase A2 (zeige YWHAZ Antikörper) (sPLA2).
Data show that the coordinated action of phospholipase A2 (zeige YWHAZ Antikörper) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (zeige ALOX15 Antikörper)) promotes inflammatory arthritis.
Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.
hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation
Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.
PLA2G2A production is induced by Pseudomonas aeruginosa.
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
, group IIA phospholipase A2
, non-pancreatic secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 2A
, phospholipase A2, membrane associated
, eted enzyme type IIA phospholipase A2
, platelet phospholipase A2
, enhancing factor
, modifier of Min1
, non-pancreatic secreted type II phospholipase A2
, secretory group II phospholipase A2
, typeII phospholipase A2