Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human PLA2G2A Antikörper:
anti-Rat (Rattus) PLA2G2A Antikörper:
anti-Mouse (Murine) PLA2G2A Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
Human Polyclonal PLA2G2A Primary Antibody für ELISA, WB - ABIN4345941
Villanueva, Little, Lambeau, Klegeris: Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells. in Molecular and cellular neurosciences 2012
This report provides the first demonstration that Phosphatidylcholine-Isoprostanes are readily hydrolyzed by group IIA, V and X Secretory Phospholipases A2.
Given an aberrant high level of sPLA2IIa in the tumor microenvironment that should be much higher than that in the blood, our findings support the notion that sPLA2IIa functions as a ligand for EGFR (zeige EGFR Antikörper) family receptors and supports CSC properties via HER/ERBB (zeige EGFR Antikörper)-elicited signaling, which may contribute to resistance to therapy and cancer progression
the activity of human cPLA2alpha (zeige PLA2G4A Antikörper) towards a multitude of glycerophospholipids species present in micelles or bilayers, was investigated.
Mutational analysis of functional sites showed that both peroxidase and PLA2 (zeige YWHAZ Antikörper) active sites were necessary for mutant Prdx6 (zeige PRDX6 Antikörper) function, and that Prdx6 (zeige PRDX6 Antikörper) phosphorylation (at T177 residue) was essential for optimum PLA2 (zeige YWHAZ Antikörper) activity.Mutant Prdx6 (zeige PRDX6 Antikörper) at its Sumo1 (zeige SUMO1 Antikörper) sites escapes and abates this adverse process by maintaining its integrity and gaining function
sPLA2-IIA activates Integrin alphaVbeta3 (zeige ITGAV Antikörper) and Integrin alpha4beta1 in an allosteric manner. (Review)
Leptin (zeige LEP Antikörper), at concentrations with minimal or no activating effects on astrocytoma cells, enhanced growth and migration promoted by low doses of sPLA2-IIA. sPLA2-IIA alone induced a transient phosphorylation pattern in the Src (zeige SRC Antikörper)/ERK (zeige EPHB2 Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper)/p70S6K (zeige RPS6KB1 Antikörper)/rS6 pathway through EGFR (zeige EGFR Antikörper) transactivation
Molecular dynamics simulations reveal structural insights into inhibitor binding modes and functionality in human PLA2G2A.
Hepatitis B virus can upregulate the expression of PLA2G2A, and serum levels of PLA2G2A are associated with the progression of hepatitis to liver cirrhosis and hepatocellular carcinoma.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (zeige YWHAZ Antikörper), lipoxygenase and cyclooxygenase.
High expression of PLA2G2A was associated with poor therapeutic response and worse survival in patients with rectal cancer receiving neoadjuvant concurrent cheomoradiotherapy (CCRT).
transgenic mice overexpressing sPLA2 -IIA keratinocytes showed enhanced activation of EGFR (zeige EGFR Antikörper) and JNK1 (zeige MAPK8 Antikörper)/2 that led to c-Jun (zeige JUN Antikörper) activation.
PLA2 promotes pulmonary inflammation and systemic disease during Streptococcus pneumoniae infection.
secretory PLA2s have important functions as genetic modifiers of inflammation and colon cancer.
Polyozellin might play an important role in the modulation of sPLA2-IIA expression and activity in response to the inflammatory diseases.
Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2beta (iPLA2beta (zeige PLA2G6 Antikörper)) and Group X Secreted Phospholipase A2 (zeige YWHAZ Antikörper) (sPLA2).
Data show that the coordinated action of phospholipase A2 (zeige YWHAZ Antikörper) IIA (sPLA2-IIA) and 12-lipoxygenase (12-LO (zeige ALOX15 Antikörper)) promotes inflammatory arthritis.
Pla2g2a sequence varies between tumor resistant and sensitive mouse strains. Some of these variations in the promoter region affect Pla2g2a expression and nonsense-mediated RNA decay also contributes to reducing Pla2g2a mRNA in tumor-sensitive strains.
hydrolysis of the mitochondrial membrane by sPLA2-IIA yields inflammatory mediators (ie, lysophospholipids, fatty acids, and mtDNA) that promote leukocyte activation
Ionomycin causes susceptibility to phospholipase A2 while temperature-induced increases in membrane fluidity fail: possible involvement of actin fragmentation.
PLA2G2A production is induced by Pseudomonas aeruginosa.
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
, group IIA phospholipase A2
, non-pancreatic secretory phospholipase A2
, phosphatidylcholine 2-acylhydrolase 2A
, phospholipase A2, membrane associated
, eted enzyme type IIA phospholipase A2
, platelet phospholipase A2
, enhancing factor
, modifier of Min1
, non-pancreatic secreted type II phospholipase A2
, secretory group II phospholipase A2
, typeII phospholipase A2