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Human Polyclonal PCM1 Primary Antibody für ICC, IF - ABIN4344087
Gilsbach, Preissl, Grüning, Schnick, Burger, Benes, Würch, Bönisch, Günther, Backofen, Fleischmann, Schübeler, Hein: Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. in Nature communications 2014
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Human Polyclonal PCM1 Primary Antibody für IP, WB - ABIN188819
Kuriyama, Bettencourt-Dias, Hoffmann, Arnold, Sandvig: Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. in Journal of cell science 2009
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Human Polyclonal PCM1 Primary Antibody für ICC, IF - ABIN4344089
Bergmann, Zdunek, Alkass, Druid, Bernard, Frisén: Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover. in Experimental cell research 2010
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Human Polyclonal PCM1 Primary Antibody für WB - ABIN518687
Akimov, Rigbolt, Nielsen, Blagoev: Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics. in Molecular bioSystems 2011
Human Polyclonal PCM1 Primary Antibody für IP, WB - ABIN188820
Aziz, Sieben, Jeganathan, Hamada, Davies, Velasco, Rahman, Katzmann, van Deursen: Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression. in The Journal of clinical investigation 2018
Human Polyclonal PCM1 Primary Antibody für FACS, IF - ABIN391696
Fang, Zhang, Yin, Zheng, Bi, Yuan: Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. in Journal of cell science 2014
In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly.
Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein)
a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer
no association between the PCM1 gene and schizophrenia in a Japanese population
Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
these data suggest a mechanism whereby the recruitment of Plk1 to pericentriolar matrix by PCM1 plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry.
Chromosomal translocation [t(8;9)(p22;p24)]/PCM1-JAK2 fusion protein activates SOCS2 and SOCS3 via STAT5 in a cutaneous T-cell lymphoma cell line.
CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation.
PCM1 interacts with Hook2 in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation.
NEK7 is essential for PCM accumulation in a cell cycle stage-specific manner.
WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1).
The data failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28).
These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to schizophrenia risk and/or protection.
DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC1 in glial function and provide a possible cellular mechanism contributing to the association of these DISC1 variants with psychiatric phenotypes.
Hook3- and PCM1-mediated dynamic assembly of pericentriolar material is essential for interkinetic nuclear migration.
multiple processes involved in regulating the abundance of NIMA (never in mitosis gene a)-related kinase 2 kinase at the centrosome including microtubule binding, the centriolar satellite component PCM-1, and localized protein degradation
To study the rearrangement created by the t(8;9)(p22;p24)used dual-colour FISH on metaphases from patient cells using labelled-BAC clones centred on PCM1.
A genetic translocation in atypical chronic myeloid leukemia yields a new PCM1-JAK2 fusion gene.
The PCM1 gene is implicated in susceptibility to schizophrenia and is associated with orbitofrontal gray matter volumetric deficits.
cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression
MicroRNA (miR)-128 regulates the proliferation and differentiation of neural progenitor cells by repressing pericentriolar material 1 (PCM1).
haploinsufficiency at the Pcm1 locus can induce a range of neuroanatomical and behavioral phenotypes that support the candidacy of this locus in neuropsychiatric disorders.
deletion of Htt in ependymal cells led to PCM1 mislocalization, alteration of the cilia layer, and hydrocephalus
results identify a novel role for PCM- 1 in cell cycle regulation, and indicate that PCM-1 must fulfill an essential function for cells to complete interphase
Pcm1 colocalized with centrosomal components in cytoplasmic granules surrounding nascent centrioles. Interfering with Pcm1 reduced the amount of centrosomal proteins at basal bodies but did not prevent centriole assembly.
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
pericentriolar material 1
, pericentriolar material 1 protein-like
, Pericentriolar material 1 protein-like
, pericentriolar material 1 protein
, pericentriolar material 1, PCM1
, pericentriolar material gene 1
, pericentriolar material-1