anti-Pferd Nucleoporin 98kDa Antikörper für Western Blotting

Recommended Nucleoporin 98kDa Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Nucleoporin 98kDa (NUP98) Antikörper
  • CG10198
  • CG10201
  • Dmel\\CG10198
  • Nup 96
  • Nup 98
  • Nup-98
  • Nup96
  • Nup98
  • Nup98-Nup96
  • Nup98/96
  • l(3)95BCd
  • nup145
  • nup98-96
  • GB12688
  • NUP98
  • 4732457F17
  • AI849286
  • im:7151238
  • zgc:113968
  • zgc:63593
  • ADIR2
  • NUP196
  • NUP96
  • Nucleoporin 98-96kD
  • nuclear pore complex protein Nup98-Nup96
  • nucleoporin 98
  • nucleoporin 98kDa
  • nucleoporin 98 L homeolog
  • Nup98-96
  • LOC408335
  • NUP98
  • LOC587580
  • Nup98
  • nup98
  • nup98.L
Epitop
N-Term
8
6
5
5
5
4
3
3
3
2
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
61
24
16
8
5
5
5
4
3
3
2
2
2
2
1
1
1
1
Wirt
Kaninchen
44
20
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
2
2
Applikation
Western Blotting (WB)
60
19
18
10
5
4
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2785490
$ 289.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
3.2286417 ABIN2781008 IF WB Rabbit N-Term Anmelden zum Anzeigen Polyclonal 1
1 ABIN468449 WB Rabbit AA 36-85 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1919059 IHC (p) WB Rabbit IgG AA 201-250 Anmelden zum Anzeigen Polyclonal 0
1 ABIN1919061 IP WB Rabbit IgG AA 900-950 Anmelden zum Anzeigen Polyclonal 0

General

Antigen Nucleoporin 98kDa (NUP98) Antikörper
Epitop N-Term
(8), (6), (5), (5), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
(61), (24), (16), (8), (5), (5), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(44), (20), (2)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(2), (2)
Applikation Western Blotting (WB)
(60), (19), (18), (10), (5), (4), (2), (2), (1)
Pubmed 1 Publikation vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN981047.
Sequenz EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL FSSSTTNSGF
Homologie Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
Produktmerkmale This is a rabbit polyclonal antibody against NUP98. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human NUP98

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung NUP98 (NUP98 Antibody Abstract)
Hintergrund The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
Alias Symbols: ADIR2, NUP196, NUP96
Protein Interaction Partner: UBC, SUMO2, SUMO3, CDC37, EED, CDC73, PAF1, ARFGEF2, FBXO6, NXF1, HDAC11, HDAC8, LMNA, HNRNPUL1, CSNK2A1, ECT2, NUP107, RAE1, SUMO1, NUMA1, rev, SIRT7, RAPGEF3, CTNNB1, NUP88, NUP159, NUP82, Nup98, Nup214, Nup188, tat, HDAC1, CREBBP, PTTG1, APC, NPM1, USP
Protein Size: 937
Molekulargewicht 98 kDa
Gen-ID 4928
NCBI Accession NM_005387, NP_005378
UniProt A8KA17
Pathways Stem Cell Maintenance, Protein targeting to Nucleus

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 937 AA

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Pan, Zhu, Gu, Cai, Bai, Yun, Zhu, Chen, Weng, Chen, Xue, Chen: "A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation." in: Oncogene, Vol. 27, Issue 24, pp. 3414-23, 2008

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Nucleoporin 98kDa (NUP98) (N-Term) antibody (ABIN2785490) WB Suggested Anti-NUP98 Antibody Titration: 0.2-1 ug/ml
Positive Control...