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show specific evidence for a cell-autonomous requirement for Msi family proteins in regulating stem cell differentiation, leading to the identification of an RNA-binding protein required for spermatogonial stem cell maintenance
MSI1 and MSI2 (zeige MSI2 Proteine) bind and regulate the mRNA stability and translation of proteins operating in essential oncogenic signaling pathways..This review provides a current overview of Musashi as a cancer driver and novel therapeutic target.
Musashi-1 has a role in regulating AKT (zeige AKT1 Proteine)-derived IL-6 (zeige IL6 Proteine) autocrinal/paracrinal malignancy and chemoresistance in glioblastoma
MSI1 was a target of miR (zeige MLXIP Proteine)-181a-5p, a microRNA involved in the regulation of cancer development. The expression levels of MSI1 and miR (zeige MLXIP Proteine)-181a-5p were negatively correlated in NSCLC.
Musashi-1 interacts with the Zika genome and enables viral replication.
Msi1promoted epithelial-mesenchymal transformation of cervical neoplasms via activation of the Wnt (zeige WNT2 Proteine) signaling pathway and contributing to poor prognosis.
our results suggest a role for MSI1 in double-strand break repair and that its inhibition may enhance the effect of radiotherapy
Results show that Meis1 (zeige MEIS1 Proteine) may have a positive feedback with Msi1 during the esophageal squamous cell carcinoma progression.
Musashi-1 expression was higher in Barrett esophagus and early esophageal adenocarcinoma compared to advanced adenocarcinoma.
miR (zeige MLXIP Proteine)-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR (zeige MLXIP Proteine)-761 repressed ovarian cancer proliferation and invasion by targeting MSI1
Concomitant loss of function of both MSI1 is sufficient to abrogate the growth of human colorectal cancer cells, and Msi gene deletion inhibits tumorigenesis in several mouse models of intestinal cancer.
leptin's direct stimulatory actions on gonadotrope GnRHR (zeige GNRHR Proteine) correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr (zeige GNRHR Proteine) mRNA.
Msi (zeige EBP Proteine) proteins are dispensable for normal homeostasis and self-renewal of the active intestinal stem cell.
photoreceptors lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi 1 (MSI1) protein. A striking feature of the photoreceptor splicing program are exons that display a "switch-like" pattern of high inclusion levels in photoreceptors and near complete exclusion outside of the retina.
Given that deregulated fatty acid metabolism plays a key role in kidney fibrosis, these results demonstrate a novel connection between fatty acid and Msi1, an RNA-binding protein, in kidney fibrosis
A Mouse Model of Targeted Musashi1 Expression in Whole Intestinal Epithelium Suggests Regulatory Roles in Cell Cycle and Stemness.
studies highlight Msi (zeige EBP Proteine) reporters as a unique tool to identify therapy resistance, and define Msi (zeige EBP Proteine) signalling as a central regulator of pancreatic cancer
the RNA-binding protein Musashi 1 competes with miR130a and -206 for interaction with tachykinin mRNA
MSI1 and MSI2 (zeige MSI2 Proteine) display distinct expression profiles during mammalian folliculogenesis and that MSI2 (zeige MSI2 Proteine) is required for pre-antral follicle development
Osteoarticular expression of Msi1 protein is increased in joints with CIA (zeige NCOA5 Proteine)-induced lesion and absent in nonlesioned joints, suggesting that this protein is expressed when the lesion is produced in order to favor tissue repair.
Msi1 is critical for constructing functional blood-testis barrier &maintaining spermatogenesis. Msi1 regulates Sertoli cell fate following heat-induced injury, likely through induction of stress granule formation & activation of p-ERK1/2 signaling
Genome-wide analysis of CPEB1- and Msi1-associated mRNAs identified 491 common targets, thus revealing a new layer of cytoplasmic polyadenylation elements-mediated translational control.
specific association of Musashi with the noncanonical poly(A) polymerase (zeige PAPOLA Proteine) germ line development defective-2 (GLD2 (zeige PAPD4 Proteine))
Xenopus Musashi proteins regulate translation of the Musashi1 mRNA during oocyte maturation.
Ringo/cyclin-dependent kinase (zeige CDK1 Proteine) and mitogen-activated protein kinase (zeige MAPK1 Proteine) signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
These findings indicate that Musashi function is necessary to establish the temporal order of maternal mRNA translation during Xenopus meiotic cell cycle progression.
Msi-1 expression is upregulated in the adult progenitor cells and plays important roles in their maintenance and/or active proliferation during amphibian gastrointestinal remodeling.
Visual deprivation for 2 days increased proliferation of musashi1-immunoreactive radial glial progenitors
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
, musashi homolog 1
, Musashi 1
, musashi 1
, RNA-binding protein Musashi homolog 1
, RNA-binding protein Musashi-1
, Musashi homolog 1(Drosophila)