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this study demonstrates that Lin28A can activates androgen receptor (zeige AR Proteine) via regulation of c-myc (zeige MYC Proteine) and promotes malignancy of ER-/Her2 (zeige ERBB2 Proteine)+ breast cancer
The results suggest that the Lin28a gene enhances the osteoblastic differentiation of human periosteum-derived cells. In addition, the Lin28a gene increases mitochondrial activity in human periosteum-derived cells.
High LIN28A expression is associated with pancreatic cancer.
the specific interaction between zinc knuckle domain of LIN28 and pre-let-7 is necessary and sufficient to induce oligouridylation.
It has been shown that the constitutive expression of Lin28a during neuronal differentiation in vitro positively and negatively affects numerous miRNAs.
ur study demonstrated that disturbance of the let-7/LIN28 double-negative feedback loop is involved in the regulation of radio- and chemo-resistance, and that let-7 and LIN28 could be employed as predictive biomarkers of response to radiotherapy or chemotherapy in non-small-cell lung cancer patients.
tight control by ESE3/EHF (zeige EHF Proteine) over the Lin28/let-7 axis is a critical barrier to malignant transformation.
MSI2 (zeige MSI2 Proteine) might play a crucial role in sustaining stemness and chemoresistance of liver cancer stem cells in LIN28A-dependent manner in hepatocellular carcinoma.
High LIN28A expression is associated with colorectal cancer.
LIN28A and LIN28B (zeige LIN28B Proteine) play cooperative roles in regulating reprogramming, naive/primed pluripotency, and stem cell metabolism.
miR (zeige MLXIP Proteine)-145 modulation of Sox2 (zeige SOX2 Proteine)-Lin28/let-7 network is crucial for neurogenesis progression.
The results reveal a key role of Wnt (zeige WNT2 Proteine)-Lin28-let7 miRNA signaling in regulating proliferation and neurogenic potential of Muller glial cells in the adult mammalian retina.
LIN28 specifically marks undifferentiated spermatogonia in mice. The LIN28-expressing undifferentiated spermatogonia exist as two subpopulations: Ngn3 (zeige NEUROG3 Proteine)-GFP-negative (high stem cell potential) and Ngn3 (zeige NEUROG3 Proteine)-GFP-positive (high differentiation commitment)
Overexpression of LIN28A, which is a hallmark of human ETMRs, augments Sonic-hedgehog (Shh (zeige SHH Proteine)) and Wnt (zeige WNT2 Proteine) signaling in embryonal tumors with multilayered rosettes precursor cells through the downregulation of let7-miRNA, and LIN28A/let7a interaction with the Shh (zeige SHH Proteine) pathway was detected at the level of Gli (zeige GLI1 Proteine) mRNA.
During ESC differentiation, Lin28 transient induction is dependent on Otx2 and Hmga2 and prevents an inappropriate excessive rise of Hmga2 levels.-
MAPK/ERK (zeige MAPK1 Proteine) directly impacts LIN28, defining an axis that connects signalling, post-transcriptional gene control, and cell fate regulation.
Sirt1 (zeige SIRT1 Proteine) knockdown abolished the protective effects of Lin28a against cardiac remodeling and dysfunction after MI, and Lin28a failed to increase the numbers of GFP-LC3 (zeige MAP1LC3A Proteine)-positive punctae and decrease aggresome and p62 (zeige GTF2H1 Proteine) accumulation in Sirt1 (zeige SIRT1 Proteine)-knockdown neonatal cardiomyocytes subjected to hypoxia-induced injury.
data point toward a complex system of regulation by Lin28a, Lin28b (zeige LIN28B Proteine), and let-7, in which Lin28b (zeige LIN28B Proteine) and let-7 can impact both puberty and growth in a sex-specific manner
the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone (zeige PTH Proteine) function.
The knockdown of Lin-28a or Lin-28b (zeige LIN28B Proteine) function by morpholino microinjection into embryos resulted in severe cell proliferation defects during early morphogenesis.
The Lin-28 is induced in Muller glia within 6 h following retinal injury and is necessary for Muller glia dedifferentiation.
Lin28 pseudogenes do not acquire patterns of tissue-specific methylation as for the parental gene, but rather are methylated in patterns specific to the local genomic environment into which they were inserted.
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
RNA-binding protein LIN-28
, protein lin-28 homolog A
, zinc finger CCHC domain-containing protein 1
, zinc finger, CCHC domain containing 1
, testis expressed gene 17
, testis-expressed protein 17
, RNA-binding protein LIN-28A
, RNA-binding protein lin-28
, lin-28 homolog A (C. elegans)