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Studies suggest there are two nonoverlapping NK cell populations that are potentially liver resident in humans: CD49a (zeige ITGA1 Proteine)+ NK cells and Eomes hi.
Reciprocal regulation of BMF (zeige BMF Proteine) and BIRC5 (zeige BIRC5 Proteine) is linked to Eomes overexpression in colorectal cancer.
Eomes(hi) NK cells can be recruited from the circulation during adult life and that circulating Eomes(lo) NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver.
EOMES expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56 (zeige NCAM1 Proteine)+ cell dysregulation.
we identified a higher Eomes mRNA expression as an independent good prognostic factor for OS and PFS in mRCC patients treated with sorafenib.
Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis.
the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects.
This study showed that EOMES (rs2724509; flanking) associated with Alzheimer disease.
This study supports the concept that poor human viral-specific CD8 (zeige CD8A Proteine)(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes
Report a global loss of 5hmC identified three new genes (ECM1 (zeige ECM1 Proteine), ATF5 (zeige ATF5 Proteine), and EOMES) with potential anti-cancer functions that may promote the understanding of the molecular mechanisms of hepatocellular carcinoma development and progression.
Smad2 (zeige SMAD2 Proteine) and Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa forms a general component of the Smad2 (zeige SMAD2 Proteine) signalling complex in zebrafish.
Eomesa has a strictly maternal role in the initiation of epiboly, and is required for normal expression of the endoderm markers sox32, bon and og9x (zeige SEBOX Proteine); however it is not essential for endoderm formation.
Eomes is a Nodal-transducing factor that acts, directly and indirectly, in concert with FoxH1 (zeige FOXH1 Proteine) to carry out all Nodal-dependent processes during early mesendoderm specification.
Eomes plays a role in specifying the embryonic organizer.
regulates the expression of a zygotic homeobox (zeige PRRX1 Proteine) transcription factor mtx2 (zeige MTX2 Proteine)
Results suggest that eomesodermin promotes endoderm induction in marginal blastomeres by facilitating the assembly of a transcriptional activating complex on the casanova promoter.
These results suggest that both Eomes genes are involved in the zebrafish immune response, particularly in lymphocyte function as has been found in mammals.
as conceptuses attach to the uterine epithelium, IFNT gene transcription is down-regulated by an increase in EOMES expression and EOMES-CREBBP (zeige CREBBP Proteine) binding in the attached trophoblast cells.
Tbr2 regulates the tempo of laminar fate implementation for all cortical layers.
results revealed Eomes expression is restricted to distinct tissues and Vgamma subsets; gammadelta T cells expressing Eomes presented a CD44 (zeige CD44 Proteine)+-activated memory phenotype with increased expression of Ly6C and Il2rb (zeige IL2RB Proteine) and showed higher IFN-gamma (zeige IFNG Proteine) production upon stimulation; Eomes expression could be induced in peripheral and thymic gammadelta T cells by IL-12 (zeige IL12A Proteine) and in particular by IL-4 (zeige IL4 Proteine)
activation of the Eomes target genes Foxa2 (zeige FOXA2 Proteine) and Lhx1 (zeige LHX1 Proteine) is associated with higher order chromatin reorganization.
this study shows that TGF-beta (zeige TGFB1 Proteine) promotes salivary gland innate lymphoid cells differentiation by suppressing Eomes
The Foxo3 (zeige FOXO3 Proteine)-Eomes pathway is central to achieve the complete specialized gene program required for pathogenic Th1 (zeige HAND1 Proteine) cell differentiation.
HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production.
increases the number of ALP (zeige CCL21A Proteine)-positive colonies after iPSC induction and decreases expression levels of Eomes and p21 mRNAs. Based on these observations, we propose that the CCR4 (zeige CCR4 Proteine)-NOT deadenylase activity contributes to iPSC induction.
Results indicated that Eomes bound to the Ifng (zeige IFNG Proteine) promoter and multiple conserved noncoding sequences in stimulation-dependent and stimulation-independent manners.
Demonstrate by using the T-box brain-2(Cre) mouse line that progenitor cells derived cells contribute 67.5% of glutamatergic but not GABAergic or astrocytic cells to all cortical layers including the earliest generated subplate zone.
a critical role for IRF4 (zeige IRF4 Proteine) in regulating protective anti-viral CD8 (zeige CD8A Proteine)+ T cell responses by ensuring a balanced ratio of T-bet to Eomes
the expression of T-bet, Eomes and GATA-3 (zeige GATA3 Proteine) in combination with additional differentiation molecules within CD4 (zeige CD4 Proteine)+ and CD8beta+ T cell subsets from different organs of healthy pigs.
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
T-box brain protein 2
, eomesodermin homolog
, eomesodermin homolog (Xenopus laevis)